Effect of Zinc Ion on Cadmium-Induced Auditory Changes

Ağirdir, Bülent Veli; Bilgen, Ibrahim; Dinç, Oktay; Özçağlar, Hasan Ümit; Fişenk, Firat; Turhan, Murat; Öner, Gülsen

doi:10.1385/bter:88:2:153

Cited by 24 publications

(17 citation statements)

References 23 publications

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“…There is substantial evidence that implicates associations of impaired balance (Bhattacharya et al 1990, 1995, 2006, 2007; Chia et al 1994, 1996; Després et al 2005; Dick et al 1999; Iwata et al 2005; Kilburn and McKinley 1996; Linz et al 1992; Ratzon et al 2000; Viaene et al 2000; Yokoyama et al 1997, 2002), hearing loss (Agirdir et al 2002; Bertoni and Sprenkle 1988; Bleecker et al 2003; de Abreu and Suzuki 2002; Forst et al 1997; Hwang et al 2009; Lasky et al 2001; Ozcaglar et al 2001; Yokoyama et al 2002), and alterations in auditory evoked potential (Araki et al 1986; Bleecker et al 2003; Murata et al 1993) with exposure to lead and cadmium. However, it is not known whether exposure to lead and cadmium induces vestibular dysfunction specifically.…”

Section: Discussionmentioning

confidence: 99%

Lead and Cadmium Levels and Balance and Vestibular Dysfunction among Adult Participants in the National Health and Nutrition Examination Survey (NHANES) 1999–2004

Min

Lee²,

Park³

et al. 2012

Environ Health Perspect

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Background: Few studies have been conducted to identify risk factors for balance and vestibular dysfunction in general populations, but previous studies have reported evidence of adverse effects of lead and cadmium on balance control in high-risk groups.Objective: We evaluated the relationship between blood lead and cadmium levels and balance and vestibular dysfunction in a general population study.Methods: We analyzed data from the 1999–2004 National Health and Nutrition Examination Survey (NHANES) of 5,574 adults ≥ 40 years of age. Balance dysfunction was evaluated by the Romberg Test of Standing Balance on Firm and Compliant Support Surfaces, which examines the ability to stand unassisted using four test conditions to evaluate vestibular system, vision, and proprioception inputs that contribute to balance. Blood levels of lead and cadmium were measured by atomic absorption spectrometry. Associations were estimated using logistic regression models adjusted for potential confounders. Associations with time to loss of balance were estimated using adjusted Cox proportional hazard models.Results: The adjusted odds ratio (OR) for balance dysfunction in association with the highest quintile (3.3–48 µg/dL) versus the lowest quintile (< 1.2 µg/dL) of lead was 1.42 [95% confidence interval (CI): 1.07, 1.89]. The corresponding OR for cadmium (0.9–7.4 µg/L vs. < 0.2 µg/L) was 1.27 (95% CI: 1.01, 1.60). The adjusted hazard ratio for time to failure for the most physiologically challenging balance test among subjects with the highest vs. lowest quintiles of blood lead was 1.24 (95% CI: 1.04, 1.48). Cadmium levels were not associated with time to failure.Conclusions: Our findings suggest that blood lead and cadmium levels may be associated with balance and vestibular dysfunction in a general sample of U.S. adults.

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Section: Discussionmentioning

confidence: 99%

Lead and Cadmium Levels and Balance and Vestibular Dysfunction among Adult Participants in the National Health and Nutrition Examination Survey (NHANES) 1999–2004

Min

Lee²,

Park³

et al. 2012

Environ Health Perspect

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“…Cd is particularly toxic to the proximal tubules in the kidneys [6] and Cd induces cellular apoptosis and causes necrosis. The increase in blood Cd levels causes a decrease in glomerular filtration rate [7].…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Ameliorates Cadmium-Induced Nephrotoxicity, Apoptosis, and Oxidative Stress in Rats is Based on its Anti-Apoptotic and Anti-Oxidant Properties

Erboğa

Kanter

Aktaş

et al. 2015

Biol Trace Elem Res

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Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Thymoquinone (TQ) is the main constituent of the essential oil obtained from black seeds (Nigella sativa) and has various pharmacological effects. The aim of the present study was to examine the nephroprotective, anti-oxidant, and anti-apoptotic effect of the TQ against Cd-induced nephrotoxicity. A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated, and Cd-treated with TQ; each group contain eight animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the amount of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in TQ-treated groups were given TQ (50 mg/kg body weight) once a day orally together with first Cd injection during the study period. The histopathological studies in the kidney of rats also showed that TQ markedly reduced the toxicity of Cd and preserved the normal histological architecture of the renal tissue. Immunohistochemical analysis revealed that TQ significantly decreased the Cd-induced over expression of nuclear factor-κB in renal tissue. Furthermore, TQ treatment resulted in decreased the number of apoptotic cells. TQ significantly suppressed lipid peroxidation, compensated deficits in the anti-oxidant defenses (reduced superoxide dismutase, glutathione peroxidase and catalase activities) in renal tissue resulted from Cd administration. These findings suggest that the nephroprotective potential of TQ in Cd toxicity might be due to its anti-oxidant and anti-apoptotic properties, which could be useful for achieving optimum effects in Cd-induced nephrotoxicity.

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“…In an animal study, zinc deficiency also enhanced the ototoxicity of salicylate 20. Although the effect of zinc supplementation in the auditory pathway has not been widely reported in the literature, there are some reports regarding zinc in the protection of cochlear hair cells from pneumolysin and cadmium‐induced ototoxicity 21, 22. It has been proposed that zinc can protect hair cells by interfering with the apoptotic cascade,21 which is the common pathway of various kinds of inner ear dysfunction.…”

Section: Introductionmentioning

confidence: 99%