Effect of Zinc Intake on Mental and Motor Development in Infants: A Meta-Analysis

Nissensohn, Mariela; Sánchez‐Villegas, Almudena; Lugo, Daniel Fuentes; Sánchez, Patricia Henrı́quez; Alonso, Jorge Doreste; Skinner, Anna Louise; Warthon-Medina, Marisol; Lowe, Nicola M; Morán, Victoria Hall; Serra-Majem, Lluís

doi:10.1024/0300-9831/a000161

Cited by 20 publications

(12 citation statements)

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“…Studies relating to infants (aged 0-12 months) were excluded from this review because the systematic review and meta-analyses in infants were conducted by the research team at ULPGC and reported elsewhere. 41…”

Section: Search Strategymentioning

confidence: 99%

“…For the purpose of this review, studies with infant were not included (n = 356) as this has been reported elsewhere. 41 A further 1814 studies were excluded because they did not assess cognitive function outcomes or they provided insufficient data to be considered for a comparative analysis, were not conducted on healthy participants, provided zinc as a multi-micronutrient supplement or were published in a language outside the scope of this study.…”

Section: Reasons For Exclusionmentioning

confidence: 99%

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Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

et al. 2015

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In developing countries, deficiencies of micronutrients are thought to have a major impact on child development; however, a consensus on the specific relationship between dietary zinc intake and cognitive function remains elusive. The aim of this systematic review was to examine the relationship between zinc intake, status and indices of cognitive function in children and adults. A systematic literature search was conducted using EMBASE, MEDLINE and Cochrane Library databases from inception to March 2014. Included studies were those that supplied zinc as supplements or measured dietary zinc intake. A meta-analysis of the extracted data was performed where sufficient data were available. Of all of the potentially relevant papers, 18 studies met the inclusion criteria, 12 of which were randomised controlled trials (RCTs; 11 in children and 1 in adults) and 6 were observational studies (2 in children and 4 in adults). Nine of the 18 studies reported a positive association between zinc intake or status with one or more measure of cognitive function. Meta-analysis of data from the adult's studies was not possible because of limited number of studies. A meta-analysis of data from the six RCTs conducted in children revealed that there was no significant overall effect of zinc intake on any indices of cognitive function: intelligence, standard mean difference of <0.001 (95% confidence interval (CI) -0.12, 0.13) P=0.95; executive function, standard mean difference of 0.08 (95% CI, -0.06, 022) P=0.26; and motor skills standard mean difference of 0.11 (95% CI -0.17, 0.39) P=0.43. Heterogeneity in the study designs was a major limitation, hence only a small number (n=6) of studies could be included in the meta-analyses. Meta-analysis failed to show a significant effect of zinc supplementation on cognitive functioning in children though, taken as a whole, there were some small indicators of improvement on aspects of executive function and motor development following supplementation but high-quality RCTs are necessary to investigate this further.

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Section: Search Strategymentioning

confidence: 99%

Section: Reasons For Exclusionmentioning

confidence: 99%

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

et al. 2015

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“…Experimental studies have demonstrated that the cytoarchitecture of the cerebral cortex can be irreversibly disturbed in iodine deficiency, causing abnormal neuron migratory patterns that are associated with cognitive impairment in children [18]. Regarding zinc, no association was found between zinc intake and mental and motor development in infants [19]. Although no significant effects of maternal vitamin B12 supplementation were observed on cognitive development in 9-month-old infants 9, increased maternal total homocysteine levels were associated with poorer cognitive performance in some of the subdomains of Bayley Scales of Infant Development-III [20].…”

Section: Discussionmentioning

confidence: 99%

Physicians' Understanding of Nutritional Factors Determining Brain Development and Cognition in the Middle East and Africa

Vandenplas

Rakhecha

Edris

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

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Purpose: Proper nutrition is essential for brain development during infancy, contributing to the continued development of cognitive, motor, and socio-emotional skills throughout life. Considering the insufficient published data in the Middle East and North Africa, experts drafted a questionnaire to assess the opinions and knowledge of physicians on the impact of nutrition on brain development and cognition in early life. Methods: The questionnaire consisted of two parts: The first focused on the responders' demographic and professional characteristics and the second questioned the role of nutrition in brain development and cognition. Descriptive statistics were used to summarize respondents' characteristics and their responses to questions. Results: A total of 1,500 questionnaires were distributed; 994 physicians responded. The majority of the surveyed physicians (64.4%) felt that nutrition impacts brain development in early childhood (0-4 years), with almost 90% of physicians agreeing/strongly agreeing that preventing iron, zinc, and iodine deficiency would improve global intelligence quotient. The majority of physicians (83%) agreed that head circumference was the most important measure of brain development. The majority of physicians (68.9%) responded that the period from the last trimester until 18 months postdelivery was crucial for brain growth and neurodevelopment, with 76.8% believing that infants breast-fed by vegan mothers have an increased risk of impaired brain development.

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“…A Cochrane systematic review (2012) concluded that there is no significant effect of zinc intake on mental and motor development in children [34]. This was nuanced by another systematic review, published later that year, stating that the effect of zinc supplementation on cognitive function might be dependent on the dose of supplementation and the duration of the intervention [35].…”

Section: Zincmentioning

confidence: 99%

Nutritional Support of Neurodevelopment and Cognitive Function in Healthy Children – An Update and Novel Insights

K¹,

Muhardi²,

Parikh³

et al. 2020

Preprint

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Proper nutrition is crucial for normal brain and neurocognitive development. Failure to optimize neurodevelopment early in life can have profound long-term implications for both mental health and quality of life. Although the first 1000 days of life represent the most critical period of neurodevelopment, the central and peripheral nervous systems continue to develop and change throughout life. All this time, development and functioning depend on many factors, including adequate nutrition. In this review, we outline the role of nutrients in cognitive, emotional, and neural development in infants and young children with special attention to the emerging roles of polar lipids and high quality (available) protein. Furthermore, we discuss the dynamic nature of the gut-brain axis and the importance of microbial diversity in relation to a variety of outcomes, including brain maturation/function and behavior are discussed. Finally, the promising therapeutic potential of psychobiotics to modify gut microbial ecology in order to improve mental well-being is presented. Here we show that the individual contribution of nutrients, their interaction with other micro-and macronutrients, and the way in which they are organized in the food matrix are of crucial importance for normal neurocognitive development.

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Effect of Zinc Intake on Mental and Motor Development in Infants: A Meta-Analysis

Cited by 20 publications

References 0 publications

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

Physicians' Understanding of Nutritional Factors Determining Brain Development and Cognition in the Middle East and Africa

Nutritional Support of Neurodevelopment and Cognitive Function in Healthy Children – An Update and Novel Insights

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