Effect of zinc gluconate, sage oil on inflammatory patterns and hyperglycemia in zinc deficient diabetic rats

Elseweidy, Mohamed M.; Ali, Abdelmoneim A.; Zein, Nabila; Mursey, Nada M.

doi:10.1016/j.biopha.2017.08.081

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…Specifically, the contents of lysozyme, IgM, C3 and C4 of Glu‐Zn group were all significantly higher than those of the ZnSO 4 group. Similar immune stimulation result of Glu‐Zn diet was found rat (Elseweidy et al, 2017). Some report was found that Glu‐Zn attenuates biomarkers of inflammation (e.g., TNF‐α, and IL‐1β) and oxidative stress (Ansari et al, 2019).…”

Section: Discussionsupporting

confidence: 81%

“…After, the biodistribution studies in rats demonstrated that Glu‐Zn has the equivalent bioavailable to Zn‐enriched yeast, but Glu‐Zn is absorbed faster than the Zn yeast (Zhang et al, 2018). Moreover, dietary administration of Glu‐Zn was found to improve the rats glycemic and inflammatory states (Elseweidy et al, 2017). Furthermore, Glu‐Zn also contributes to stimulate the antioxidant defences and alleviate adverse effects of heat stress on broiler chickens (Aluwong et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Luo

Wang

et al. 2021

Aquacult. Nutr.

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Zn is one of the essential elements to maintain normal fish metabolic process (including growth, development and reproduction), which have different chemical status in nature including inorganic, organic and nano‐sized. In this work, the efficacy of gluconic acid zinc (Glu‐Zn), nano zinc oxide (Nano ZnO), zinc sulphate (ZnSO4) on the growth performance, tissue mineral elements deposition, antioxidant activity and immune response of the tilapia fish Nile tilapia (Oreochromis niloticus) was evaluated. Three experimental diets were prepared by adding different forms of Zn sources (ZnSO4 as a control group) with same Zn concentration (40 mg/kg) and used to feed fish for 60 days. The biological trial results displayed that the growth performance of Nile tilapia has not obviously affected by different Zn form source supplement. However, Glu‐Zn and Nano ZnO supplements have significantly stimulated the Zn and Cu absorption deposition efficiency in the fish tissues as compared to ZnSO4 group. Besides, there was a significant increase in Cu‐Zn superoxide dismutase (35.03 U/mgprot), alkaline phosphatase (79.34 U/mgprot), aspartate aminotransferase (23.42 U/L), alanine aminotransferase (18.45 U/L), glutathione peroxidase (171.24 U/mgprot) and fatty acid synthase (11.55 ng/mL) content in Glu‐Zn treatment. Additionally, Glu‐Zn supply significantly increased serum lysozyme (9.91 U/mL), immunoglobulin M (0.48 g/L), complement 3 (0.74 g/L) and complement 4 (0.95 g/L) activity of Nile tilapia. Also, compared to ZnSO4 diet, lysozyme (11.44 U/mL) and complement 4 (0.63 g/L) content were obviously higher in fish fed Nano Zn diet. These findings revealed that supplementation with Glu‐Zn as a Zn source in feed is better than ZnSO4 for improving tissue mineralization, antioxidant stress, alleviate lipid peroxidation and immunity response of Nile tilapia. Meantime, Nano ZnO also played a positive role in the tissue mineralization and immunity response of Nile tilapia.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Luo

Wang

et al. 2021

Aquacult. Nutr.

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“…Although this is the first report that zinc supplementation could reverse the impairment of learning and memory abilities abilities of FGR rats, the molecular mechanism was various. For example, zinc involves in regulating exchange of oxygen and nutrients [ 1 ], inflammatory reaction [ 21 ], vascular smooth muscle cells response [ 22 ], etc . Hence, it is necessary to further explore the potential mechanism of zinc on learning and memory abilities abilities of FGR rats.…”

Section: Discussionmentioning

confidence: 99%

Zinc improves learning and memory abilities of fetal growth restriction rats and promotes trophoblast cell invasion and migration via enhancing STAT3-MMP-2/9 axis activity

et al. 2017

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Fetal growth restriction (FGR) is a well-known risk factor for cognitive dysfunction, especially for learning and memory abilities. However, knowledge about prevention and treatment methods of learning and memory abilities of fetal are limit. Here, Morris water maze and passive avoidance tests showed zinc supplementation could protect the impairment of the learning and memory abilities caused by FGR. As accumulating evidence suggested that insufficiency of placental trophoblast cell invasion was closely related to FGR fetal neurodevelopmental dysplasia, we further explored the relationship between zinc supplementation during pregnancy and placental trophoblast. Microarray identified 346 differently expressed genes in placental tissues with and without zinc supplementation, and GO and KEGG analyses showed these differently expressed genes were highly enriched in cell invasion and migration and STAT3 pathway. Protein-protein interaction(PPI) analysis found that STAT3 interacted with matrix metalloproteinase-2/9 (MMP-2/9). In vivo, western blot results authenticated that the expression levels of phospho-STAT3, STAT3, MMP-2 and MMP-9 were up-regulated in placental tissues after zinc treatment. To validate whether zinc could promotes trophoblast cell invasion and migration via enhancing STAT3-MMP-2/9 activity. In vitro, Transwell assay was performed, and we observed that abilities of invasion and migration were obviously increased in zinc treated trophoblast cells. And phospho-STAT3, STAT3, MMP-2 and MMP-9 expression levels were correspondingly increased in zinc treated trophoblast cells, which were dose-dependent. Moreover, gain–of-function and loss-of-function of STAT3 confirmed that zinc promotes cell invasion and migration via regulating STAT3 mediated up-regulation of MMP-2/9 activity. We propose that activation of MMP-2/9 mediated by STAT3 may contribute to invasion and migration of trophoblast cells, which improved neurodevelopmental impairment of FGR rats probably via contributing to placental development. Our findings are the first to show a possible mechanism of reversing neurodevelopmental impairment of FGR rats by zinc supplementation, holding promise for the development of novel therapeutic modalities for learning and memory abilities impairment caused by FGR.

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“…Recently, in vivo studies by Elseweidy et al showed that Salvia officinalis oil intake considerably lowered hyperglycemia and possessed antibacterial, antioxidant, and anti-inflammatory activities. In these studies, intraperitoneal administration of sage oil (0.042 mg/kg body weight daily) in zinc-deficient diabetic rats for 8 weeks decreased serum glucose to 94.17 mg/dL, while the serum glucose level of the zinc-deficient control group was 547 mg/dL [ 179 ]. A toxicological study of sage oil reported that more than 0.5 g/kg can lead to convulsion due to its action on the nervous system [ 180 ].…”

Section: Herbal-based Antidiabetic Medicines and Overview Of The Anti...mentioning

confidence: 99%

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

et al. 2022

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Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.

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Effect of zinc gluconate, sage oil on inflammatory patterns and hyperglycemia in zinc deficient diabetic rats

Cited by 6 publications

References 56 publications

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Growth performance, tissue mineralization, antioxidant activity and immune response of oreochromis niloticus fed with conventional and gluconic acid zinc dietary supplements

Zinc improves learning and memory abilities of fetal growth restriction rats and promotes trophoblast cell invasion and migration via enhancing STAT3-MMP-2/9 axis activity

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

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