Effect of Zinc Deficiency on Bone Collagenase and Collagen Turnover

Abstract

The effect of zinc deficiency on bone collagenase activity and collagen turnover was studied in the chick. Zinc deficiency symptoms, evident after 8 days on the low zinc diet, included tibia deformities and decreased alkaline phosphatase. Bone collagen metabolism was markedly altered, with a significant reduction in collagen synthesis and turnover. Half-turnover time for tibia collagen was 13 days in the control and 35 days in the zinc-deficient chicks. Tibia collagenase activity was reduced by 40-80% in the zinc-deficient as compared to the control chicks. Heparin markedly increased collagenase activity in the zinc-deficient tibias elevating activity to control levels. But commercially available heparin was found high in zinc content which may explain this effect entirely. These data show that zinc deficiency decreases bone collagen turnover and probably accounts for the leg deformities seen in zinc-deficient chicks.

Effect of Zinc Level and Source (Zinc Oxide Vs. Zinc Glycine) on Bone Mechanical and Geometric Parameters, and Histomorphology in Male Ross 308 Broiler Chicken

“…It plays a crucial role as a catalyst of many enzymes that affect bone development, suggesting its role in bone disorders (Yamaguchi & Gao, 1998). Zn functions as a metal component of alkaline phosphatase, a metalloenzyme that plays a key function in the formation of new bone (Starcher et al, 1980). Moreover, Zn increases the synthesis of growth factors, such as insulin-like growth factor 1 (IGF-1), and influences the activity of calcium-regulating hormones (Lowe et al, 2002).…”

A moderately high intake compared to a low intake of zinc depresses magnesium balance and alters indices of bone turnover in postmenopausal women

“…However, the increased N-telopeptide excretion with high zinc intake might be indicating that bone collagenase activity was depressed and bone turnover was decreased during the low dietary zinc period. In zinc-deficient chicks, half-turnover time for tibia collagen was almost tripled and tibia collagenase activity was reduced by 40-80% when compared to zinc-adequate chicks (Starcher et al, 1980). These defects in collagen metabolism were suggested as being responsible for the leg deformities of zinc-deficient chicks.…”

Availability of Dietary Zinc Sources and Effects on Performance of Pacific White Shrimp <i>Litopenaeus vannamei</i>(Boone)

“…It is estimated that proteins with zincbinding domains account for approximately 10% of the total human proteome and it is likely that this is the case across animal species (Andreini et al, 2006). Zinc is an important component of numerous enzymes and transcription factors and plays crucial roles in cellular growth, immune function, reproduction, neural function, connective tissue metabolism and antioxidant function (Starcher et al, 1980;Coleman, 1992;Shankar and Prasad, 1998;Underwood and Suttle, 1999;Blanchard et al, 2001;Ho et al, 2003;Cousins et al, 2003). Zinc is an essential trace element for shrimp and other crustaceans (Davis et al, 1992;Shiau and Jiang, 2006) and is known to play important roles in immune function, lipid metabolism, gene expression, Corresponding author email: smpall@yahoo.com reproduction and growth (Mendez et al, 2001;Shiau and Jiang, 2006;Li et al, 2010).…”