Effect of Zinc-Carnosine Chelate Compound (Z-103), A Novel Antioxidant, on Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

Yoshikawa, Toshikazu; Naito, Yuji; Tanigawa, Tohru; Yoneta, Tomoyuki; Yasuda, Masahiko; Ueda, Shigenobu; Oyamada, Hirokazu; Kondo, Motoharu

doi:10.3109/10715769109088958

Cited by 72 publications

(33 citation statements)

References 17 publications

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“…In vivo, Z-103 also has been reported to be effective in the treatment of acute gastric injuries [20,21] In the present study, the dose of Z-103 was less than the reported toxic level [22,23] and no apparent side effects were noticed. Z-103 was as effective in the treat ment of colitis as SASP, which frequently has been used clinically.…”

Section: Effect Of Z-103 On Tnb-induced Colitismentioning

confidence: 66%

Effect of Z-103 on TNB-lnduced Colitis in Rats

et al. 1997

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Z-103 is a chelate compound consisting of zinc ion and .L-carnosine. In this study, we investigated the protective effect of Z-103 against colonic damage induced by 2,4,6-trinitrobenzene sulfonic acid (TNB) in rats. Colonic inflammation was induced by administering TNB dissolved in 50% ethanol (120 mg/ml) in male Wistar rats (total volume of 0.25 ml per rat) following a 48-hour fast. After the administration of TNB, Z-103 was given at a dose of 30 mg/kg per rat for 1 week. A second group of rats received sulfasalazine (SASP) at 300 mg/kg and a third group of rats received 30 mg/kg of ZnSO₄ for 1 week. Colonic inflammation was assessed 1 week following TNB administration. Both macro- and microscopic evaluation showed that the inflammatory responses induced by TNB were reduced by treatment with Z-103, SASP and ZnSO₄ The score (graded from 0 to 5 according to the macroscopic lesions) and colonic wet weight (distal 8 cm of the colon) were significantly decreased by treatment with Z-103, SASP and ZnSO₄ The increase in thiobarbituric acid-reactive substances in the colonic mucosa following TNB administration were inhibited in the Z-103 and SASP groups. These results suggest that Z-103 is as effective against TNB-induced colitis as SASP.

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Section: Effect Of Z-103 On Tnb-induced Colitismentioning

confidence: 66%

Effect of Z-103 on TNB-lnduced Colitis in Rats

et al. 1997

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“…In ischemia-reperfusion injury of the stomach, superoxide and hydroxyl radicals are consid ered as the major reactive oxygen radicals. The xanthine-xanthine oxidase system in the gastric mucosal microcirculation is the main source of superoxide radicals, which subse quently produce hydroxyl radicals via the Fenton reaction in the stomach [28][29][30]. In the light of the aforementioned, we used the xanthine-xanthine oxidase system as the source of superoxide radicals and lipid peroxi dation system induced by hydroxyl radicals in vitro.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Acetaminophen against Acute Gastric Mucosal Lesions Induced by Ischemia-Reperf usion in the Rat

Nakamoto

Kamisaki²,

Wada³

et al. 1997

Pharmacology

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We examined the effect of acetaminophen, an analgesic and antipyretic drug, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Ischemia-reperfusion was induced by clamping the celiac artery for 30 min with a small clip. Sixty minutes after repefusion, the total area of erosions was measured. Acetaminophen (300 and 500 mg/kg) administered intraperitoneally 90 min before the ischemia significantly reduced the total area of erosions. The drug also inhibited the increase in lipid peroxide levels induced by ischemia-reperfusion in the gastric tissue and the increase in lipid peroxidation caused by the hydroxyl radical, OH^·, in vitro. Gastric prostaglandin E₂ (PGE₂) contents tended to increase after ischemia-reperfusion in both control and acetaminophen-treated groups. A significant difference in gastric PGE2 contents between control and acetaminophen-treated groups was not observed. The results indicate that acetaminophen may protect the gastric mucosa against ischemia-reperfusion injury, probably by blocking hydroxyl-radical-induced membrane damage.

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“…and is found to be an important cause of cell membrane destruction and cell damage [55]. MDA is a highly reactive species and crosslinks DNA with protein and thus damages the cells [56], disrupts its activity leading to chronic diseases.…”

Section: Inhibition Of Lipid Peroxidationmentioning

confidence: 99%

Inhibition of gastric H⁺,K⁺‐ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale

Siddaraju

Dharmesh

2007

Molecular Nutrition Food Res

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Ulcer is a common global problem characterized by acute gastric irritability, bleeding, etc. due to either increased gastric cell proton potassium ATPase activity (PPA) or perturbation of mucosal defence. Helicobacter pylori has been identified as a major ulcerogen in addition to oxidative stress and nonsteroidal anti-inflammatory drugs. In this paper, we report ginger-free phenolic (GRFP) and ginger hydrolysed phenolic (GRHP) fractions of ginger (Zingiber officinale) as potent inhibitors of PPA and H. pylori growth. GRFP and GRHP inhibited PPA at an IC(50) of 2.9 +/- 0.18 and 1.5 +/- 0.12 microg/mL, exhibiting six- to eight-fold better potency over lansoprazole. GRFP is constituted by syringic (38%), gallic (18%) and cinnamic (14%) acids and GRHP by cinnamic (48%), p-coumaric (34%) and caffeic (6%) acids as major phenolic acids. GRFP and GRHP further exhibited free radical scavenging (IC(50) 1.7 +/- 0.07 and 2.5 +/- 0.16), inhibition of lipid peroxidation (IC(50) 3.6 +/- 0.21 and 5.2 +/- 0.46), DNA protection (80% at 4 microg) and reducing power abilities (80-338 U/g) indicating strong antioxidative properties. GRFP and GRHP may thus be potential in-expensive multistep blockers against ulcer.

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Effect of Zinc-Carnosine Chelate Compound (Z-103), A Novel Antioxidant, on Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

Cited by 72 publications

References 17 publications

Effect of Z-103 on TNB-lnduced Colitis in Rats

Effect of Z-103 on TNB-lnduced Colitis in Rats

Protective Effect of Acetaminophen against Acute Gastric Mucosal Lesions Induced by Ischemia-Reperf usion in the Rat

Inhibition of gastric H⁺,K⁺‐ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale

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Effect of Zinc-Carnosine Chelate Compound (Z-103), A Novel Antioxidant, on Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

Cited by 72 publications

References 17 publications

Effect of Z-103 on TNB-lnduced Colitis in Rats

Effect of Z-103 on TNB-lnduced Colitis in Rats

Protective Effect of Acetaminophen against Acute Gastric Mucosal Lesions Induced by Ischemia-Reperf usion in the Rat

Inhibition of gastric H+,K+‐ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale

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Inhibition of gastric H⁺,K⁺‐ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale