Effect of zinc and rare-earth element addition on mechanical, corrosion, and biological properties of magnesium

Kottuparambil, Rakesh Rajan; Bontha, Srikanth; Rangarasaiah, Ramesh Motagondanahalli; Arya, Shashi Bhushan; Jana, Anuradha; Das, Mitun; Balla, Vamsi Krishna; Amrithalingam, Srinivasan; Prabhu, T. Ram

doi:10.1557/jmr.2018.311

Cited by 19 publications

(1 citation statement)

References 57 publications

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“…See Figure 14. The total deformation of a WE43 alloy will be concentrated towards the areas where the grain boundaries of the different phases converge, causing cracks to start and also reducing ductility [44][45][46][47]. The equivalent elastic deformation stimulates the propagation of these cracks from the grain borders to the outside.…”

Section: Finite Element Methodmentioning

confidence: 99%

Effect of sterilization on 3-point dynamic response to in vitro bending of an Mg implant.

Becerra

Rodríguez

Arroyo

et al. 2021

Preprint

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Background: The aim of the study is to characterize a biomedical magnesium alloy and highlighting the loss of mechanical integrity due to the sterilization method. Ideally, when using these alloys is to delay the onset of degradation so that the implant can support body loads and avoid toxicological effects due to the release of metal ions into the body. Methods: Standardized procedures according to ASTM F-1264 and ISO-10993-5 were used, respecting detailed methodological controls to ensure accuracy and reproducibility of the results, this testing methodology is carried out in accordance with the monographs of the Pharmacopoeia for the approval of medical devices and obtaining a health registration. An intramedullary implant (IIM) manufactured in magnesium (Mg) WE43 can support loads of the body in the initial period of bone consolidation without compromising the integrity of the fractured area. A system with these characteristics would improve morbidity and health costs by avoiding secondary surgical interventions. Results: As a property, the fatigue resistance of Mg in aggressive environments such as the body environment undergoes progressive degradation, however, the autoclave sterilization method drastically affects fatigue resistance, as demonstrated in tests carried out under in vitro conditions. Coupled with this phenomenon, the relatively poor biocompatibility of Mg WE43 alloys has limited applications where they can be used due to low acceptance rates from agencies such as the FDA. However, Mg alloy with elements such as yttrium and rare earth elements (REEs) have been shown to delay biodegradation depending on the method of sterilization and the physiological solution used. With different sterilization techniques, it may be possible to keep toxicological effects to a minimum while still ensuring a balance between the integrity of fractured bone and implant degradation time. Therefore, the evaluation of fatigue resistance of WE43 specimens sterilized and tested in immersion conditions (enriched Hank's solution) and according to ASTM F-1264, along with the morphological, crystallinity, and biocompatibility characterization of the WE43 alloy allows for a comprehensive evaluation of the mechanical and biological properties of WE43. Conclusions: These results will support decision-making to generate a change in the current perspective of biomaterials utilized in medical devices (MDs), to be considered by manufacturers and health regulatory agencies. An implant manufactured in WE43 alloy can be used as an intramedullary implant, considering keeping elements such as yttrium-REEs below as specified in its designation and with the help of a coating that allows increasing the life of the implant in vivo.Trial registration: N/A

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Section: Finite Element Methodmentioning

confidence: 99%

Effect of sterilization on 3-point dynamic response to in vitro bending of an Mg implant.

Becerra

Rodríguez

Arroyo

et al. 2021

Preprint

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In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications

Jana

Das

Balla

2021

J Biomedical Materials Res

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Magnesium (Mg) and its alloys have been widely explored as a potential biodegradable implant material. However, the fast degradation of Mg‐based alloys under physiological environment has hindered their widespread use for implant applications till date. The present review focuses on in vitro and in vivo degradation of biodegradable Mg alloys, and preventive measures for biomedical applications. Initially, the corrosion assessment approaches to predict the degradation behavior of Mg alloys are discussed along with the measures to control rapid corrosion. Furthermore, this review attempts to explore the correlation between in vitro and in vivo corrosion behavior of different Mg alloys. It was found that the corrosion depends on experimental conditions, materials and the results of different assessment procedures hardly matches with each other. It has been demonstrated the corrosion rate of magnesium can be tailored by alloying elements, surface treatments and heat treatments. Various researches also studied different biocompatible coatings such as dicalcium phosphate dihydrate (DCPD), β‐tricalcium phosphate (β‐TCP), hydroxyapatite (HA), polycaprolactone (PCL), polylactic acid (PLA), and so on, on Mg alloys to suppress rapid degradation and examine their influence on new bone regeneration as well. This review shows the need for a standard method of corrosion assessment to predict the in vivo corrosion rate based on in vitro data, and thus reducing the in vivo experimentation.

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Comparison of Effects of Heat Treatment on Mechanical Properties and Microstructural Behavior of Extruded AZ31 and AM50 Magnesium Alloys

Sapmaz¹,

Kurtulus²,

Zeybek³

et al. 2021

The Minerals, Metals &Amp; Materials Series

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Effect of zinc and rare-earth element addition on mechanical, corrosion, and biological properties of magnesium

Abstract: Abstract

Cited by 19 publications

References 57 publications

Effect of sterilization on 3-point dynamic response to in vitro bending of an Mg implant.

Effect of sterilization on 3-point dynamic response to in vitro bending of an Mg implant.

In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications

Comparison of Effects of Heat Treatment on Mechanical Properties and Microstructural Behavior of Extruded AZ31 and AM50 Magnesium Alloys

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