Effect of Yoga on Clinical Outcomes and Quality of Life in Patients With Vasovagal Syncope (LIVE-Yoga)

Sharma, Gautam; Ramakumar, Venkatakrishnan; Sharique, Mohd; Bhatia, Rohit; Naik, Nitish; Mohanty, Sriloy; Agarwal, Aman; Meti, Mohini; Shukla, Akriti; Deepti, Siddharthan; Bansal, Raghav; Gupta, Anunay; Ahmed, A Shaheer; Pandey, R M; Narang, Rajiv; Mishra, Sundeep; Saxena, Anitá; Juneja, Rajnish; Investigators, LIVE-Yoga

doi:10.1016/j.jacep.2021.09.007

Cited by 18 publications

(10 citation statements)

References 34 publications

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“…Recently, two randomized studies have suggested practicing yoga as an effective treatment for VVS 24,25 . These trials are also limited by being open‐label and providing personalized training and supervision as part of their intervention.…”

Section: Discussionmentioning

confidence: 99%

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Implementation of supervised physical training to reduce vasovagal syncope recurrence: A randomized controlled trial

Aghajani

Tavolinejad

Sadeghian

et al. 2022

Cardiovasc electrophysiol

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Introduction: Physical techniques used for the prevention of vasovagal syncope have limited evidence for efficacy. We aimed to evaluate multimodal supervised physical training as a treatment approach. Methods: In this 1:1 randomized trial, patients with ≥2 episodes of clinically diagnosed vasovagal syncope were included. On top of standard care, the intervention arm performed supervised tilt training and aerobic exercise in six sessions at a cardiac rehabilitation center (three sessions during the first month, and then at 3-month intervals), plus home tilt training. The control arm received standard care with a similar protocol of home tilt training. The primary outcome was time to first syncopal recurrence during 1 year of follow-up.Results: Fifty participants were randomized (mean age: 34.5 ± 14.8 years; 64% female). The rate of syncopal recurrence was 28% and 64% within the intervention and control arms, respectively, with significantly higher syncope-free survival at 1 year in the intervention arm (Log-rank p = .003). The frequency of recurrent syncopal events was significantly lower with physical training (p = .017). Participants in the intervention arm reported significantly higher adherence to the home tilt training program (80% vs. 52%; p = .037).Conclusion: Among patients with recurrent vasovagal syncope, a supervised program of tilt training and aerobic exercise reduced syncopal recurrence. Future trials are warranted to further investigate multimodal supervised physical techniques as a therapeutic approach in treating vasovagal syncope.

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Section: Discussionmentioning

confidence: 99%

“…22,23 Recently, two randomized studies have suggested practicing yoga as an effective treatment for VVS. 24,25 These trials are also…”

Section: Implications For Vvs Treatmentmentioning

confidence: 97%

Implementation of supervised physical training to reduce vasovagal syncope recurrence: A randomized controlled trial

Aghajani

Tavolinejad

Sadeghian

et al. 2022

Cardiovasc electrophysiol

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“…They also postulated that positive effects of yoga could be through combined central and peripheral mechanisms, which comprise various isotonic postures involving different muscle groups leading to enhanced muscle and vascular tone in addition to building muscle strength, which can not only blunt the venodilatation phase of a syncope episode but also accelerate the venous return. 22 Additionally, pranayama breathing and relaxation techniques have been shown to increase parasympathetic tone and improve autonomic balance which could potentially reduce the sympathetic overdrive phase and interrupt the activation of the cmechanoreceptors, which is a vital stage in the syncope cascade. 14,23 Jayaprakash S et al, randomized 97 symptomatic subjects with recurrent reflex VVS (>3 episodes in the past 1 year) and positive head-up tilt test to guideline-directed therapy (Group 1 n= 47) or yoga therapy (Group 2 n= 50).…”

Section: Methodsmentioning

confidence: 99%

A systematic review on physiological role of yoga and pranayama in management of orthostatic hypotension and vasovagal syncope

Balaji P A,

Varne

2023

IJCAP

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OH and VVS are increasingly recognized as important causes of impairment of quality of life and potentially of poor prognosis. Existing management therapies have modest effect. Recently few studies have emerged and have demonstrated the efficacy of yoga and pranayama in disorders having autonomic imbalance, suggesting its possible efficacy in OH and VVS.This review aims to determine the effectiveness of yogic practices in patients with orthostatic hypotension (OH) and recurrent vasovagal syncope (VVS). A Medline search was done in Google chrome to review relevant articles in English literature considering the eligibility criteria that the article should focus on yoga and pranayama and its physiological effects on OH and VVS. The main outcome expected was attenuation of OH and frequency of attacks of syncope and presyncope.: Out of the total 86 articles searched, 7 articles (3 RCTs, 3 observational/interventional, 1 review) full filled the eligibility criteria and depicted that yogic practices can have positive impact in attenuation of orthostatic hypotension and reduce the frequency of attacks of syncope and presyncope, among patients with recurrent VVS. However, we recommend higher-quality RCTs in future to confirm our results.

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“…Finally, two recent studies reported that yoga improves outcomes and quality of life. 130 , 131 Few of the specific poses could plausibly improve peripheral physiology to prevent syncope. In fact, one of the most important poses was the corpse pose.…”

Section: Treatment Of Vasovagal Syncopementioning

confidence: 99%

Twenty-five years of research on syncope

Fedorowski,

Kulakowski,

Brignole

et al. 2023

Europace

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Over the last 25 years, the Europace journal has greatly contributed to dissemination of research and knowledge in the field of syncope. More than 400 manuscripts have been published in the journal. They undoubtedly improved our understanding of syncope. This symptom is now clearly differentiated from other forms of transient loss of consciousness. The critical role of vasodepression and/or cardioinhibition as final mechanisms of reflex syncope is emphasized. Current diagnostic approach sharply separates between cardiac and autonomic pathways. Physiologic insights have been translated, through rigorously designed clinical trials, into non-pharmacological or pharmacological interventions and interventional therapies. The following manuscript is intended to give the reader the current state of the art of knowledge of syncope by highlighting landmark contributions of the Europace journal.

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Effect of Yoga on Clinical Outcomes and Quality of Life in Patients With Vasovagal Syncope (LIVE-Yoga)

Cited by 18 publications

References 34 publications

Implementation of supervised physical training to reduce vasovagal syncope recurrence: A randomized controlled trial

Implementation of supervised physical training to reduce vasovagal syncope recurrence: A randomized controlled trial

A systematic review on physiological role of yoga and pranayama in management of orthostatic hypotension and vasovagal syncope

Twenty-five years of research on syncope

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