“…YTX can induce different cell death modalities through activation of caspase-dependent and caspase-independent signaling pathways (Korsnes and Espenes, 2011 ; Korsnes et al, 2011 ; López et al, 2011 ; Tobío et al, 2012 ; Alonso et al, 2013 ). Cytotoxic effects vary significantly among cells exposed to it, depending on concentration and time of exposure (de la Rosa et al, 2001 ; Leira et al, 2002 ; Malaguti et al, 2002 ; Alfonso et al, 2003 ; Franchini et al, 2004 ; Callegari and Rossini, 2008 ; Ronzitti and Rossini, 2008 ; Orsi et al, 2010 ; Tubaro et al, 2010 ; Martín-López et al, 2012 ; Pang et al, 2014 ; Fernández-Araujo et al, 2015 ; Ferron et al, 2016 ). Anti-allergic and anti-tumoral activities inhibiting melanoma tumor growth and subacute immunotoxicity has been recently reported (Tobío et al, 2016 ; Ferreiro et al, 2017 ).…”