Effect of xylitol and xylitol–fluoride lozenges on approximal caries development in high‐caries‐risk children

Stecksén‐Blicks, Christina; Holgerson, Pernilla Lif; Twetman, Svante

doi:10.1111/j.1365-263x.2007.00912.x

Cited by 30 publications

(78 citation statements)

References 27 publications

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“…12,14,17 Nevertheless, the frequent use of xylitol chewing gum should be controlled to prevent the occurrence of microbial resistance. [15][16][17] This finding may be related to factors such as formation of acids resulting from glucose and/or polysaccharides resulting from sucrose. 33 The optimum length of time for using xylitol should be further evaluated in order to avoid or minimise the emergence of microbial resistance.…”

Section: Discussionmentioning

confidence: 92%

Antimicrobial effects of the combination of chlorhexidine and xylitol

et al. 2010

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Section: Discussionmentioning

confidence: 92%

Antimicrobial effects of the combination of chlorhexidine and xylitol

et al. 2010

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“…The population of this study developed an average DMFS of 2.7 during this 2-year study, among which the majority (1.8) were lesions to approximal surfaces. The Author concludes that "the results of this 2 years study do not support the administration of tablets containing fluoride and xylitol for dental caries prevention among young adolescents with a high caries risk" (13). Burt stated as well that "little firm evidence exists for the efficacy of dietary fluoride supplements when taken from birth or soon after" adding that "fluoride supplements are a risk factor for fluorosis" and that "the preeruptive cariostatic benefits of fluoride are minor" (14).…”

Section: Discussionmentioning

confidence: 99%

The role of fluoride tablets in the prophylaxis of dental caries. A literature review

Tomasin

Pusinanti

Zerman

2015

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“…describes the characteristics of the accepted articles and the DSs derived from the results presented. All six articles were published in the English language in peer‐reviewed journals that are listed in PubMed, and reported the findings from five separate clinical trials conducted in Budapest 26,27 , Costa Rica (country‐wide) 24 , French Polynesia 22 , San José, Costa Rica 26 and Umeå, Sweden 23 . All trials followed a parallel‐group study design.…”

Section: Ds Extraction and Analysismentioning

confidence: 99%

Anticariogenic effect of xylitol versus fluoride – a quantitative systematic review of clinical trials

Mickenautsch

Yengopal

2012

International Dental Journal

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The objective of this study was to appraise the clinical evidence and its bias risk regarding the anticariogenic effect of xylitol in comparison with that of fluoride. Databases were searched for clinical trials up to 18 March 2011. Article inclusion criteria were as follows: caries-related primary outcomes were tested; xylitol was compared with topical fluoride in some form; two-arm (or more) clinical trial including test/control group(s); prospective study design. Article exclusion criteria were as follows: no computable data were reported; test and control groups were not followed up in the same way; chewing gum was the main form of clinical application in either group. Individual continuous datasets were extracted from accepted articles. Selection and performance/detection bias were assessed. Sensitivity analysis was used to investigate attrition bias risk. Egger's regression and funnel plot was used to investigate publication bias risk. Twelve articles were included. Of these, six were accepted and six excluded, and 21 continuous datasets were extracted. Owing to the high clinical heterogeneity, no meta-analysis was performed. The addition of xylitol to existing fluoride regimes may be beneficial in the prevention of caries. However, all identified trials were limited by potential risk of selection, performance/detection and attrition bias. The funnel plot and Egger's regression results (-2.80; 95% confidence interval -4.01, -1.58; P = 0.0001) indicated possible publication bias risk. External fluoride access may have confounded the measured anticariogenic effect of xylitol. The evidence found contains a high risk of bias and may be limited by confounder effects. Future high-quality randomised controlled trials are needed in order to provide conclusive evidence on this topic.

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Effect of xylitol and xylitol–fluoride lozenges on approximal caries development in high‐caries‐risk children

Abstract: The results from this 2-year trial did not support a self-administered regimen of xylitol- or xylitol/fluoride-containing lozenges for the prevention of approximal caries in young adolescents with high caries risk.

Cited by 30 publications

References 27 publications

Antimicrobial effects of the combination of chlorhexidine and xylitol

Antimicrobial effects of the combination of chlorhexidine and xylitol

The role of fluoride tablets in the prophylaxis of dental caries. A literature review

Anticariogenic effect of xylitol versus fluoride – a quantitative systematic review of clinical trials

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