Effect of xanthan gum and carboxymethyl cellulose on structure, functional and sensorial properties of yam balls

Asiamah, Ebenezer; Buckman, Evelyn S.; Peget, Frank; Akonor, P. T.; Padi, Alice; Boateng, Constance; Affrifah, Nicole Sharon

doi:10.1016/j.heliyon.2022.e11200

Cited by 1 publication

(1 citation statement)

References 34 publications

(25 reference statements)

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“…Since human bone is constantly subjected to mechanical forces, vital for some specific processes such as homeostasis, skeletal formation, resorption and adaption [ 57 ], the substitutes implanted in bone defects should possess similar or at least comparable features [ 58 ]. TA-XT2 Plus is a versatile device used to study various features of polymeric materials, such as mechanical properties [ 59 ], texture profile analysis [ 60 ], or mucoadhesive properties [ 61 ]. For example, TA-XT2 was used to analyse alginate beads’ behaviour at compressive stress, presented as hardness of the beads [ 62 ], breaking force, and Young’s Modulus [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration

et al. 2023

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The tendency of population aging is continuously increasing, which is directly correlated with a significative number of associated pathologies. Several metabolic bone diseases such as osteoporosis or chronic kidney disease–mineral and bone disorders involve a high risk of fractures. Due to the specific fragility, bones will not self-heal and supportive treatments are necessary. Implantable bone substitutes, a component of bone tissue engineering (BTE) strategy, proved to be an efficient solution for this issue. The aim of this study was to develop composites beads (CBs) with application in the complex field of BTE, by assembling the features of both biomaterials’ classes: biopolymers (more specific, polysaccharides: alginate and two different concentrations of guar gum/carboxymethyl guar gum) and ceramics (more specific, calcium phosphates), in a combination described for the first time in the literature. The CBs prepared by double crosslinking (ionic and physically) showed adequate physico-chemical characteristics and capabilities (morphology, chemical structure and composition, mechanical strength, and in vitro behaviour in four different acellular simulated body fluids) for bone tissue repair. Moreover, preliminary in vitro studies on cell cultures highlighted that the CBs were free of cytotoxicity and did not affect the morphology and density of cells. The results indicated that the beads based on a higher concentration of guar gum have superior properties than those with carboxymetilated guar, especially in terms of mechanical properties and behaviour in simulated body fluids.

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