Effect of Work Conditions and Work Environments on the Formation of 8-OH-dG in Nurses and Non-Nurse Female Workers

Ishihara, Itsuko; Nakano, Masahiro; Ikushima, Miharu; Hara, Yoshiko; Yoshimine, Toshiko; Haraga, Miki; Nakatani, Junko; Kawamoto, Rieko; Kasai, Hiroshi

doi:10.7888/juoeh.30.293

Cited by 26 publications

(18 citation statements)

References 3 publications

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“…Our comparatively young healthy workers might not yet have reached their plateau, so they might have increasing HDL concentrations within our followup. However, when under chronic oxidative stress caused by simultaneous e-ALT [30] and shift work exposure [31] , our early middle-aged subjects might have significantly weaker capabilities for quantitatively increasing HDL.…”

Section: Changes Of Mets-components Among Our Male Workers Within 5 Ymentioning

confidence: 80%

“…Our follow-up observations confirmed that persistent day-night RSW accelerates the progression toward MetS among the e-ALT workers. e-ALT can work with other risk factors to worsen the inflammatory state [30] , and shift work brings about longterm oxidative stress [31] ; therefore a possible explanation for our male shift workers with e-ALT tending to develop MetS might be aggravated systemic chronic inflammatory reactions [37,38] . Due to the dramatically rising occurrence rate of MetS, we strongly suggest screening, follow-up, and treatment of MetS for workers with both e-ALT and unavoidable long-term rotational shift work exposures.…”

Section: Increasing Mets-component Numbers and Development Of Mets Ammentioning

confidence: 99%

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Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Lin¹,

Hsiao²,

Chen³

2009

WJG

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AIM:To examine whether shift work accelerates metabolic syndrome (MetS) development among early middle-aged males with elevated alanine aminotransferase (e-ALT). METHODS:A retrospective, observational followup study on MetS development at a 5-year interval was conducted using health examination data. Nine hundred and ninety six male employees not fulfilling MetS criteria at screening were enrolled. Age, MetScomponents, liver enzymes, serological markers for viral hepatitis, abdominal ultrasound, insulin resistance status, lifestyles, and workplace factors were analyzed. RESULTS:The prevalence of elevated serum ALT (> 40 U/L, e-ALT) at baseline was 19.1%. There were 381 (38.3%) workers with long-term exposures to daynight rotating shift work (RSW). 14.2% of subjects developed MetS during follow-up. After 5 years, the workers with e-ALT had significantly unfavorable changes in MetS-components, and higher rates of MetS development, vs subjects with normal baseline ALT levels. Workers with both baseline e-ALT and 5-year persistent RSW (pRSW) exposure had the highest rate of MetS development. Also, e-ALT-plus-pRSW workers had a significant increase in MetS-components at follow-up, compared with the other subgroups. After controlling for potential confounders, e-ALT-plus-pRSW workers posed a significant risk for MetS development (odds ratio, 2.7; 95% confidence interval, 1.4-5.3, vs workers without baseline e-ALT nor pRSW). CONCLUSION:We suggest that all early middleaged male employees with e-ALT should be evaluated and managed for MetS. Particularly in terms of job arrangements, impacts of long-term RSW on MetS development should be assessed for all male employees having baseline e-ALT.

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Section: Changes Of Mets-components Among Our Male Workers Within 5 Ymentioning

confidence: 80%

Section: Increasing Mets-component Numbers and Development Of Mets Ammentioning

confidence: 99%

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Lin¹,

Hsiao²,

Chen³

2009

WJG

View full text Add to dashboard Cite

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“…Additionally, increased oxidative stress associated with different jobs has been demonstrated by isolated studies. However, exhaustive and prolonged working also has been shown to increase oxidative stress in shift workers (8)(9)(10)(11) .…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, limited numbers of research studies have been performed to evaluate the oxidative stress parameters of the shift nurses; however, no research study has been performed to investigate the metabolic activities of the nurses on their shifts. Studies that have been previously performed have shown an increased oxidative stress in nurses working on their shifts (4,(9)(10)(11) . Beyond the previous published studies, we found an increased oxidative stress at the end of shifts in all nurses compared to baseline parameters.…”

mentioning

confidence: 99%

Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shifts

Ulaş

Büyükhatipoğlu

Kırhan³

et al. 2013

Rev. esc. enferm. USP

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Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shiftsArtigo originAl AbStRActThe aim of this study was to evaluate the oxidative stress and metabolic activities of nurses working day and night shifts. Intensive care unit (ICU) (n=70) and ordinary service (OS) nurses (n=70) were enrolled in the study. Just before and the end of the shifts, blood samples were obtained to measure the participants' oxidative stress parameters. Metabolic activities were analyzed using the SenseWear Armband. Oxidative stress parameters were increased at the end of the shifts for all OS and ICU nurses compared to the beginning of the shifts. Compared to the OS nurses, the ICU nurses' TAS, TOS, and OSI levels were not significantly different at the end of the day and night shifts. The metabolic activities of the OS and ICU nurses were found to be similar. As a result, the OS and ICU nurses' oxidative stress parameters and metabolic activities were not different, and all of the nurses experienced similar effects from both the day and night shifts.

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“…Also, increased level of urinary 8-OH-dG was found in shift work in comparison to the result of those who were employed in part time. Their results showed a positive relationship between 8-OH-dG levels of nurses in the 35 -45 age group and the individual scores of their depressive states (17).…”

Section: Discussionmentioning

confidence: 93%

Serum Pro-oxidant-Antioxidant Balance Assay in Nurses who Working Day and Rotating Night Shift

et al. 2016

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Background: Nursing is a very stressful occupation, particularly when associated with changing shift working that may result in oxidative stress. Oxidative Stress is created by a misbalance between pro-oxidants and antioxidants towards pro-oxidants. Damage to lipids, protein, DNA, growth and cell function is obtained as result of oxidant. OS has been played an important role in many of diseases. In this study, we assessed the potential for OS by determining the pro-oxidant-antioxidant balance assay (PAB assay) in nurses who worked variable shift patterns; compared with nurses only working day shifts and a non-nurse control group.

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Effect of Work Conditions and Work Environments on the Formation of 8-OH-dG in Nurses and Non-Nurse Female Workers

Cited by 26 publications

References 3 publications

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shifts

Serum Pro-oxidant-Antioxidant Balance Assay in Nurses who Working Day and Rotating Night Shift

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