Effect of whole body vibration (WBV) therapy on bone density and bone quality in osteopenic girls with adolescent idiopathic scoliosis: a randomized, controlled trial

Lam, TP; Ng, Benjamin; Cheung, Wing-Hoi; Lee, Wayne; Qin, Ling; Cheng, Jack C. Y.

doi:10.1007/s00198-012-2144-1

Cited by 54 publications

(45 citation statements)

References 44 publications

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“…Wren et al 45 reported changes in tibial cortical bone density, but not tibial or spinal trabecular BMD among 31 children with cerebral palsy during LMS, versus a standing period. Studies of LMS among young females with idiopathic scoliosis and low BMD, 46 or with fracture history and low BMD, 18 also reported improvements in appendicular rather than in spinal BMD. These regional differences in the effects of LMS on BMD may relate to the proximity of the device to body region, with potential loss of vibratory energy as the signal travels from the distal lower extremity to the trunk, 47 or to differences in capacity to respond to mechanical signals, with some regions more attuned to functional adaptation than others.…”

Section: Discussionmentioning

confidence: 97%

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors

et al. 2016

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Importance Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density any time before or after diagnosis. Objective To evaluate the ability of low magnitude, high frequency mechanical stimulation to enhance bone mineral density among childhood cancer survivors. Design Double-blind randomized controlled trial from June 1, 2010-January 22, 2013. Participants were randomized (stratified by sex and Tanner stage) to either a placebo device or low magnitude, high frequency mechanical stimulation. Setting St. Jude Children’s Research Hospital; intervention completed at home. Participants Survivors, ages 7-17 years, previously treated at St. Jude Children’s Research Hospital, in remission, at least five years from diagnosis, with whole body or lumbar spine bone mineral density Z-scores ≤−1.0. Intervention Placebo or low magnitude, high frequency mechanical stimulation (0.3 g, 32-37Hz) for two 10-minute sessions, seven days a week for one year. All participants were prescribed daily vitamin D and calcium. Main outcome measures Changes in areal and volumetric bone mineral density and bone biomarkers were compared by analysis of variance, adjusted for strata. Results Forty-eight of 65 randomized participants completed this double-blind study with median adherence of 70.1% for intervention and 63.7% for placebo groups. With intention-to-treat analysis, mean whole body bone mineral density Z-score by dual x-ray absorptiometry improved by 0.25±0.78 in the intervention (N=22), but decreased by −0.19±0.79 in the placebo group (N=26) p=0.05). Circulating osteocalcin at 12 months correlated with change in total body bone mineral density (r=0.35, p=0.02). Participants completing ≥70% of prescribed sessions increased 11.2±11.3% in tibial trabecular bone volume compared to those completing <70% who decreased −1.3±9.9% (p=0·02). Change in circulating receptor activator of nuclear factor kappa-B ligand was higher in the intervention than in the placebo group (0.06±0.16 vs. −0.04±0.17 pmol/L, p=0.04). Conclusions and relevance Pediatric cancer survivors with low bone mineral density may benefit from low magnitude, high frequency mechanical stimulation as a novel, safe, and convenient intervention to optimize peak bone mass during youth, alone or in conjunction with other therapies. Trial Registration NCT01010230. Vibration Intervention For Bone Enhancement In Childhood Cancer Survivors, www.clincialtrials.gov

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Section: Discussionmentioning

confidence: 97%

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors

et al. 2016

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“…The healing process can be influenced by various factors, of which biomechanical condition at the fracture site is considered as one of the key determinants (Einhorn, 1998;Hannouche et al, 2001 et al, 2014). Some studies provide evidence that WBV has effects on the musculoskeletal system, including improving muscle function (Rees et al, 2008;Sitja-Rabert et al, 2015), increasing bone mineral density (BMD) (Lam et al, 2013;Verschueren et al, 2004), reducing risks of falls and improving muscle strength and balancing ability . Low-magnitude high-frequency vibration (LMHFV), a type of WBV with magnitude usually lower than 1 ×g [magnitude, in gravitational acceleration (m/s…”

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confidence: 99%

The effect of whole body vibration on fracture healing – a systematic review

Wang¹,

Leung²,

Chow³

et al. 2017

eCM

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This systematic review examines the efficacy and safety of whole body vibration (WBV) on fracture healing. A systematic literature search was conducted with relevant keywords in PubMed and Embase, independently, by two reviewers. Original animal and clinical studies about WBV effects on fracture healing with available full-text and written in English were included. Information was extracted from the included studies for review. In total, 19 articles about pre-clinical studies were selected. Various vibration regimes are reported; of those, the frequencies of 35 Hz and 50 Hz show better results than others. Most of the studies show positive effects on fracture healing after vibration treatment and the responses to vibration are better in ovariectomised (OVX) animals than non-OVX ones. However, several studies provide insufficient evidence to support an improvement of fracture healing after vibration and one study even reports disruption of fracture healing after vibration. In three studies, vibration results in positive effects on angiogenesis at the fracture site and surrounding muscles during fracture healing. No serious complications or side effects of vibration are found in these studies. WBV is suggested to be beneficial in improving fracture healing in animals without safety problem reported. In order to apply vibration on fractured patients, more well-designed randomised controlled clinical trials are needed to examine its efficacy, regimes and safety. Keywords THE EFFECT OF WHOLE BODY VIBRATION ON FRACTURE HEALING -A SYSTEMATIC REVIEW IntroductionFracture is a common musculoskeletal problem with high morbidity. Most fractures usually heal uneventfully well, but about 5-10 % of the fractures result in impaired healing, such as delayed union and non-union (Rozen et al., 2007). Therefore, it is of great importance to develop more efficient management to minimise delayed union and nonunion. Fracture healing is a complicated biological process that consists of an inflammatory stage, repair stage and remodelling stage (Kalfas, 2001). The healing process can be influenced by various factors, of which biomechanical condition at the fracture site is considered as one of the key determinants (Einhorn, 1998;Hannouche et al., 2001 et al., 2014). Some studies provide evidence that WBV has effects on the musculoskeletal system, including improving muscle function (Rees et al., 2008;Sitja-Rabert et al., 2015), increasing bone mineral density (BMD) (Lam et al., 2013;Verschueren et al., 2004), reducing risks of falls and improving muscle strength and balancing ability . Low-magnitude high-frequency vibration (LMHFV), a type of WBV with magnitude usually lower than 1 ×g [magnitude, in gravitational acceleration (m/s2 )] and frequency ranged from 20 to 90 Hz (Bemben et al., 2010;Fuermaier et al., 2014;von Stengel et al., 2011), is also reported to have positive effects on osteogenic differentiation and osteogenesis (Dumas et al., 2010;Kim et al., 2012;Leung et al., 2014;Luu et al., 2009). Some previous studies usi...

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“…Some of the previous studies have briefed in some outcomes as: improvement in balance [21], increases in bone mineral density [22], increased blood circulation [23], reduction in pain level [24], increased muscle strength and power [25] and in special cases like in knee osteoarthritis [26], scoliosis [27], spinal problems [28], cardiovascular issues, stroke cases, multiple sclerosis [29], Parkinson's disease [30], osteopenia, diabetes mellitus [31], rewardingly improvement in overall health of the person. Furthermore, for inactive and elderly, it is the best solution to improve health and quality of life.…”

Section: Introductionmentioning

confidence: 99%

The Effect of WBV on Balance, Mobility and Strength in Aging Adults: A Systematic Review

Awan¹,

Khan²,

Perveen³

2017

Biol syst Open Access

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Whole body vibration (WBV) exposure in elderly adults is found to increase physical activity and so the overall health status. For analyzing effects of WBV on muscle power, balance and overall mobility among elderly adults of age more than 60 years, comprehensive article search was performed from year 2013 till January 2017 on electronic databases of Medley, Google scholar and IEEE (institute of electrical and electronic engineering), search strategy and inclusion criteria was specified initially and then articles were recruited accordingly. Randomized controlled trails targeting WBV effects, compared to control group with some moderate exercise or no intervention at all, on muscle power, balance and mobility were studied and data extracted about author name, publication year, age and number of participants, WBV parameters, protocols of study, vibrating platform, description and comparison among interventions. Initially 656 records were identified in preliminary search through the databases, four studies finally were considered as eligible. Lower body muscle strength (14.8 ± 3.3 to 16.5 ± 3.6) and upper body strength (17.9 ± 4.5 to 20.3 ± 3.6) have shown significant results in all the studies. Improvement in balance and mobility was also significant with P<0.005 in comparison with control groups with no interventions. WBV alone or combined with exercise training program seems to improve muscle strength, overall balance and increased mobility among elder adults. Direct comparison among studies was not possible because of differences among parameters and study protocols. More extensive and well-designed research is still needed to establish efficacy and to understand the effects and influences more clearly.

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Effect of whole body vibration (WBV) therapy on bone density and bone quality in osteopenic girls with adolescent idiopathic scoliosis: a randomized, controlled trial

Abstract: WBV was effective for improving aBMD at the femoral neck of the dominant side and lumbar spine BMC in AIS subjects.

Cited by 54 publications

References 44 publications

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors

The effect of whole body vibration on fracture healing – a systematic review

The Effect of WBV on Balance, Mobility and Strength in Aging Adults: A Systematic Review

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