Effect of White Tea Extract on Antioxidant Enzyme Activities of Streptozotocin –Induced Diabetic Rats

Al-Shiekh, Ahlam A. M.; Alshati, Ali; Sarhan, M. A.

doi:10.21608/eajbsc.2014.13710

Cited by 8 publications

(9 citation statements)

References 53 publications

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“…This means that the protective effect of peel extracts may act by either directly scavenging the reactive oxygen metabolites, due to the presence of various antioxidant compounds, or by increasing the synthesis of antioxidant molecules. These results are in agreement with the study of white tea extract supplementation in diabetic rats which showed an increase in the levels of antioxidants [43].…”

Section: Discussionsupporting

confidence: 93%

Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

et al. 2020

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Background Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel extracts of Irvingia wombolu against diabetes complications. Methods Diabetes was induced by intravenous administration of streptozotocin (STZ) (50 mg/kg) through the right jugular vein on rats and animals with blood glucose values of at least 250 mg/dl received orally aqueous extract of peel (AEP), hydroethanolic extract of peel (HEP), tolbutamide and DMSO 10%. Their effects on the concentration of blood glucose, total cholesterol, HDL-C, LDL-C, triglycerides, malondialdehyde (MDA) and activities of catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic and normal rats were investigated using standard methods. Results Twenty-one days of treatment with AEP and HEP at a dose of 400 mg/kg significantly (P < 0,05) reduced the fasting blood glucose to a point of reaching normal value. The antihyperlipidemic assessment of extracts revealed a significant (P < 0,05) decrease in total cholesterol, triglycerides, LDL levels, and a significant (P < 0,05) increase in HDL level in the plasma of treated diabetic rats. Furthermore, plasma biomarkers of liver and kidney dysfunction were significantly reduced in treated diabetic rats. We also observed increased activities of catalase, SOD, and reduced glutathione in diabetic treated rats. Conclusion The present findings suggest that AEP and HEP have a protective effect on liver, kidney, and heart in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.

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Section: Discussionsupporting

confidence: 93%

Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

et al. 2020

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“…CAT is a heme-containing enzyme which catalyses the decomposition of H 2 O 2 to water and O 2 and thus protect the cell from oxidative damage [39]. GPx plays a central role in the catabolism of H 2 O 2 and the detoxification of endogenous metabolic peroxides and hydroperoxides which catalyzes GSH [40].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of phloretin on hyperglycemia mediated oxidative stress in experimental diabetic rats

Nithiya¹,

Udayakumar²

2017

Integr Food Nutr Metab

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“…Administration of a white tea extract to rats with hyperglycemia triggered a significant increase in SOD, CAT, GPX, and GSC-Px levels as well as a decrease in MDA levels in the liver and blood serum, which indicates stimulation of the synthesis of exogenous antioxidative enzymes [126]. Similarly, in a study by Sharifzadeh et al [127], the use of green tea extract in rats with induced diabetes revealed that the experimental factor lowered LPO and total thiol group content but did not influence the TAC level.…”

Section: Antioxidative Activitymentioning

confidence: 95%

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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The physiological markers of autoimmune diabetes include functional disorders of the antioxidative system as well as progressing inflammation and the presence of autoantibodies. Even though people with type 1 diabetes show genetic predispositions facilitating the onset of the disease, it is believed that dietary factors can stimulate the initiation and progression of the disease. This paper analyses the possibility of using tea as an element of diet therapy in the treatment of type 1 diabetes. Based on information available in literature covering the last 10 years, the impact of regular tea consumption or diet supplements containing tea polyphenols on the oxidative status as well as inflammatory and autoimmune response of the organism was analyzed. Studies conducted on laboratory animals, human patients, and in vitro revealed positive effects of the consumption of tea or polyphenols isolated therefrom on the diabetic body. Few reports available in the literature pertain to the impact of tea on organisms affected by type 1 diabetes as most (over 85%) have focused on cases of type 2 diabetes. It has been concluded that by introducing tea into the diet, it is possible to alleviate some of the consequences of oxidative stress and inflammation, thus limiting their destructive impact on the patients’ organisms, consequently improving their quality of life, regardless of the type of diabetes. Furthermore, elimination of inflammation should reduce the incidence of immune response. One should consider more widespread promotion of tea consumption by individuals genetically predisposed to diabetes, especially considering the drink’s low price, easy availability, overall benefits to human health, and above all, the fact that it can be safely used over extended periods of time, regardless of the patient’s age.

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Effect of White Tea Extract on Antioxidant Enzyme Activities of Streptozotocin –Induced Diabetic Rats

Cited by 8 publications

References 53 publications

Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats

Protective effect of phloretin on hyperglycemia mediated oxidative stress in experimental diabetic rats

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

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