Effect of whey protein supplementation on weight and body composition indicators: A meta-analysis of randomized clinical trials

Sepandi, Mojtaba; Samadi, Mohammad; Shirvani, Hossein; Alimohamadi, Yousef; Taghdir, Maryam; Goudarzi, Forough; Akbarzadeh, Isa

doi:10.1016/j.clnesp.2022.05.020

Cited by 8 publications

(1 citation statement)

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“…WP supplementation regardless of RE significantly inhibited an increase in fat mass and promoted an increase in lean mass, indicating simultaneous anti-sarcopenic and anti-obesity effects in sarcopenic obesity. A recent meta-analysis showed that whey protein intake significantly increased lean body mass [ 40 ]. Moreover, WP supplementation regardless of RE significantly inhibited increasing BW and reduced fat weight in sarcopenic obesity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Whey Peptide Supplementation on Sarcopenic Obesity in High-Fat Diet-Fed Mice

Lim

2022

Nutrients

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The incidence of sarcopenic obesity gradually increased in parallel with the aged population. This research examined the effects of whey peptide (WP) supplementation with/without resistant exercise (RE) on sarcopenic obesity. Male 8-month-old C57BL/6J mice were fed a control diet (10 kcal% fat) or a high-fat diet (60 kcal% fat) for 8 weeks. High-fat diet-fed mice were randomly divided into four groups: obesity control group (OB), RE (RE only), WP (WP only), and WPE (RE and WP). WP supplementation (1500 mg/day/kg B.W.) gavage and RE (ladder climbing, five times weekly, 8–10 repetitions, 10–20% B.W. load) were conducted for an additional 8 weeks. Protein and mRNA levels of markers related to energy, protein, and lipid metabolism were analyzed in skeletal muscle and adipose tissue by one-way analysis of variance (ANOVA). WP supplementation regardless of RE significantly suppressed the increasing fat mass (p = 0.016) and decreasing lean mass (p = 0.014) and alleviated abnormal morphological changes in skeletal muscle and adipose tissue (p < 0.001). In adipose tissue, WP supplementation regardless of RE ameliorated dysregulated energy metabolism and contributed to the reduction in adipocyte differentiation (PPAR-γ (p = 0.017), C/EBPα (p = 0.034)). In skeletal muscle, WP supplementation regardless of RE alleviated energy metabolism dysregulation and resulted in down-regulated protein degradation (Atrogin-1 (p = 0.003), MuRF1 (p = 0.006)) and apoptosis (Bax) (p = 0.004). Taken together, the current study elucidated that WP supplementation regardless of RE has potential anti-obesity and anti-sarcopenic effects in sarcopenic obesity.

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Section: Discussionmentioning

confidence: 99%