Effect of Wenhua Juanbi Recipe (温化蠲痹方) on expression of receptor activator of nuclear factor kappa B ligand, osteoprotegerin, and tumor necrosis factor receptor superfamily member 14 in rats with collagen-induced arthritis

Abstract

WJR likely acts by reducing RANKL expression and increasing OPG expression, thus inhibiting RANKL/RANK interaction and reducing LIGHT expression, thereby inhibiting osteoclast formation/activation to block bone erosion.

Wenhua Juanbi Recipe Attenuates Rheumatoid Arthritis via Inhibiting miRNA-146a-Mediated Autophagy

“…AI scores were considered as follows: 0 = inflammation, 4 = heavy inflammation in the limbs and joints, and greater than 4 = successful establishment of the CIA model. After the model was successfully established, the rats were further randomly divided into three treatment groups: model (saline), WJR (intragastric administered with WJR at 22.9 g/kg/d), and MTX (intragastrically administered with MTX at 0.78 mg/kg/w) [ 24 ]. Animals were treated for four weeks.…”