Effect of Wellness Education on Quality of Life of Patients With Non–Small Cell Lung Cancer Treated With First-Line Icotinib and on Their Family Caregivers

Abstract

Objective : To examine the effects of a wellness-education intervention on quality of life (QOL) of patients with NSCLC treated with icotinib and on their caregivers. Methods : This feasibility study was a prospective pilot randomized controlled trial to evaluate a wellness-education intervention in NSCLC patients and caregivers undergoing icotinib treatment. The participants in the wellness-education group were provided with well-being information over 8 weeks. The Family Environment Scale (FES), Functional Assessment of Cancer Therapy–Lung (FACT-L), Caregiver QOL Index–Cancer Scale (CQOLC), and Hospital Anxiety and Depression Scale (HADS) were measured at baseline prior to randomization and after 8 weeks. Patients completed the FACT-L and HADS, caregivers completed the CQOLC and FES. Results : 67 patients/caregivers in the wellness-education group and 71 in the control group could be analyzed. Feasibility targets were the following: (1) >70% study enrollment of eligible patients; (2) >90% of participants completing this study; (3) <10% missing data. Wellness-education group had better change scores at 8 weeks for the emotional well-being subscale of FACT-L (12.8 vs 15.6, P = .014), anxiety subscale of HADS (6.1 vs 6.7, P = .030), adaptation (66.0 vs 54.7, P = .037) and financial subscales of CQOLC (70.8 vs 69.8, P = .044), and the cohesion (7.3 ± 1.8 vs 5.7 ± 1.7, P= .021) and conflict (3.4 ± 1.9 vs 4.5 ± 1.7, P = .031) subscales of the FES. Conclusion : Wellness-education in patients/caregivers with NSCLC treated with icotinib are feasible and could improve patients’ QOL and their relationship with caregivers.

Effects of Dyadic Interventions on Quality of Life among Cancer Patients: An Integrative Review

“…Among 27 studies,[ 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 ] 7 studies[ 31 40 41 46 49 50 53 ] were pretest–posttest design. Mixed design was used in 3 studies[ 32 42 45 ] and 17[ 33 34 35 36 37 38 39 43 44 47 48 51 52 54 55 56 57 ] studies were randomized controlled trial. Majority, nineteen studies[ 32 33 34 35 36 37 38 39 40 41 43 45 46 47 48 50 52 53 57 ] were conducted in the USA while two each in the Netherlands,[ 42 51 ] the United Kingdom,[ …”

“…Majority, nineteen studies[ 32 33 34 35 36 37 38 39 40 41 43 45 46 47 48 50 52 53 57 ] were conducted in the USA while two each in the Netherlands,[ 42 51 ] the United Kingdom,[ 44 56 ] and China. [ 54 55 ] Finally, one study each was conducted in Indonesia[ 49 ] and Chile. [ 31 ]…”

“…Almost half of the studies[ 33 34 35 36 37 38 39 41 43 47 48 51 52 53 ] were conducted in multi-sites and the remaining[ 31 32 40 42 44 45 46 49 50 54 55 56 57 ] in one site. Sample size of 3 studies[ 40 46 50 ] was less than or equal to ten dyads, while sample size was between 11 and 20 dyads in 3 studies,[ 31 56 57 ] 21 and 30 dyads in 4 studies,[ 42 45 48 49 ] 31 and 40 dyads in 5 studies[ 32 39 41 51 53 ] 41 and 50 dyads in 2 studies,[ 33 52 ] 61–70 dyads in 1 study,[ 38 ] 71 and 80 dyads in 3 studies,[ 35 36 44 ] 91 and 100 in 1 study,[ 43 ] 100 and 200 dyads in 2 studies,[ 54 55 ] 200 and 300 dyads in 2 studies,[ 34 47 ] and above 300 dyads, i.e., 302 dyads in one study. [ 37 ] Sample size calculation was shown in only four studies.…”

“…Regarding the type of cancer included, 6 studies[ 40 42 46 51 54 55 ] included patients with lung cancer, 6 studies[ 37 41 43 48 53 57 ] included different types and stages of cancer, 5 studies[ 33 34 38 39 47 ] included breast cancer, 3 studies[ 55 56 45 56 ] included prostate cancer, 2 studies[ 31 49 ] included terminal cancer, 2 studies[ 32 42 ] included gastrointestinal cancer, 1 study[ 44 ] included ovarian cancer, and 1 study[ 50 ] included high-grade glioma (brain cancer). In 18 studies, the eligibility age was mentioned to be 18 years or more for providing consent.…”

“…[ 33 52 54 ] Studies[ 35 38 39 ] tested between counseling and education. One study each had intervention education,[ 55 ] dance,[ 48 ] writing,[ 44 ] and training along with education and counseling. [ 31 ]…”