Effect of Weight Reduction on Rhinometric Measurements in Overweight Patients with Obstructive Sleep Apnea

Abstract

Weight reduction does not seem to have any effect on nasal resistance or volume in overweight patients with mild OSA. Patients with OSA and impaired nasal breathing need specific medical or surgical treatment to restore nasal airflow.

Weight loss from lifestyle interventions and severity of sleep apnoea: a systematic review and meta-analysis

“…The WMD for AHI was −16.09 (95% CI −25.64, −6.54); however, this sample was again highly heterogeneous (I 2 = 92.2%). Sensitivity analysis was conducted to determine if outcomes differed when using the 12-week data [27], rather than the 12-month data of the study with different time points [31]. This analysis showed similar results (WMD = −15.76 (95% CI −26.45, −5.06), I 2 = 92.7%).…”

“…Follow-up data were reported for three of the RCTs. Specifically, follow-up data from Kemppainen et al [27] and Tuomilehto et al [31] were reported at 24 and 60 months [32,33]; follow-up data from Foster [24] were reported at 24 and 48 months [28]; and follow-up data from Johansson et al [25] were reported at 12 months [26]. Overall, the eight RCTs included 618 participants.…”

“…Follow-up studies could not be included in the metaanalysis as this would be including multiple data points for the same study. For one RCT, data were reported at 12 weeks (following very low-calorie diet intervention) [27] and at 12 months following the active maintenance period of the intervention [31]. Only the 12-month data were included in the meta-analysis as it assessed the entire intervention period [31].…”

“…Nine articles from four different RCTs assessed the impact of intensive lifestyle intervention compared with conservative lifestyle intervention [24,27,28,[31][32][33], usual diet [22,25,26] or a weight maintenance control [30] on sleep apnoea outcomes and so were eligible to be included in the meta-analyses. Only those studies reporting the immediate effect of the intervention were included in the metaanalysis.…”

Sleep apnoea and metabolic dysfunction

“…Six randomised controlled trials have compared the effect of intensive lifestyle changes versus routine care in OSA [74][75][76][77][78][79]. The trials were mixed in duration, design and protocols employed, and no consistency was observed in the diet, exercise or structuring of the programmes employed (table 1).…”