Effect of Weight Loss After Bariatric Surgery on Left Ventricular Mass and Ventricular Repolarization in Normotensive Morbidly Obese Patients

Mukerji, Rita; Petruc, Marius; Fresen, John; Terry, Boyd E.; Govindarajan, Gurushankar; Alpert, Martin A.

doi:10.1016/j.amjcard.2012.03.045

Cited by 52 publications

(45 citation statements)

References 19 publications

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“…14, 15 A bariatric surgery study has demonstrated that dramatic changes can occur in heart size with weight reduction. 16 It is interesting that our data suggest lowering blood pressure is associated with favorable effects on LVM and geometry but that the need for pharmacologic therapy remains associated with higher LVM. This suggests the presence of a chronic effect of hypertension on the left ventricle related to exposure to higher blood pressure prior to treatment.…”

Section: Discussionmentioning

confidence: 80%

Longitudinal Determinants of Left Ventricular Mass and Geometry

Gidding

Liu

Colangelo

et al. 2013

Circ: Cardiovascular Imaging

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Background The purpose of this study was to identify determinants of 20 year change in left ventricular (LV) mass (LVM) and LV geometry in black and white young adults in the CARDIA Study. Methods and Results We studied 2426 black and white men and women (54.7% Caucasian) aged 43-55 years with cardiovascular (CV) risk factor data and echocardiograms from CARDIA year 5 and 25 examinations. In regression models, year 25 LVM or relative wall thickness was the dependent variable and with year 5 echo values, age, gender, race, body mass index (BMI), change in BMI, mean arterial blood pressure, change in mean blood pressure, heart rate (HR), change in HR, tobacco use, presence of diabetes, alcohol use, and physical activity score as independent variables. LVM and relative wall thickness increased while prevalence of normal geometry declined from 84.2% to 69.7%. Significant determinants of year 25 LVM/m2.7 were year 5 LVM, year 5 and change in BMI, year 5 and change in mean arterial pressure, year 5 and change in HR, baseline diabetes, and year 5 tobacco and/or alcohol use (overall r2 = 0.40). Significant determinants of year 25 relative LV wall thickness were year 5 value, black race, change in BMI, year 5 and change in mean arterial pressure, starting smoking, and year 5 diabetes. (overall r2 = 0.11). Conclusions Prevalence of abnormal LV hypertrophy and geometry increased from young adulthood to middle age. Both young adult CV risk traits and change in these traits predicted change in LV mass/geometry.

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Section: Discussionmentioning

confidence: 80%

Longitudinal Determinants of Left Ventricular Mass and Geometry

Gidding

Liu

Colangelo

et al. 2013

Circ: Cardiovascular Imaging

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“…Of note, six studies [23,24,30,33,35,36] examined 726 morbid obese individual candidates for bariatric surgery.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…According to criteria based on left-ventricular mass indexed to BSA, LVH prevalence ranged from 22.0 [27] to 67.0% [21]; the corresponding figures for left-ventricular mass indexed to height 2.7 were 20.0 [17] and 85.0% [32]. A meta-analysis aimed at comparing the prevalence of LVH in normotensive (six studies, 418 participants) [17][18][19]26,31,35] and hypertensive obese individuals (eight studies, 1976 participants) [15,16,21,22,28,29,32,33], and failed to find significant difference between the groups (54 versus 59%; P ¼ 0.44).…”

Section: Left-ventricular Hypertrophy Prevalencementioning

confidence: 99%

Left-ventricular hypertrophy and obesity

Cuspidi

Rescaldani

Sala

et al. 2014

Journal of Hypertension

167

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“…Epidemiological studies have shown that obesity is associated with comorbidities, such as cardiovascular disease [3,4], metabolic disease (e.g., diabetes) [5,6], chronic kidney disease and immunological disorders [7]. Obesity also exerts an important and complex influence on the respiratory system.…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea and pulmonary function in patients with severe obesity before and after bariatric surgery: a randomized clinical trial

Aguiar

Freitas

Santos

et al. 2014

Multidisciplinary Respiratory Medicine

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BackgroundThe increasing prevalence of obesity in both developed and developing countries is one of the most serious public health problems and has led to a global epidemic. Obesity is one of the greatest risk factors of obstructive sleep apnea (OSA), which is found in 60 to 70% of obese patients mainly due to the buildup of fat tissue in the upper portion of the thorax and neck. The aim of the present randomized clinical trial is to assess daytime sleepiness, sleep architecture and pulmonary function in patients with severe obesity before and after bariatric surgery.MethodsThis randomized, controlled trial, was designed, conducted, and reported in accordance with the standards of The CONSORT (Consolidated Standards of Reporting Trials) Statement. Patients were divided into a bariatric surgery group and control group. The clinical evaluation was performed at the Sleep Laboratory of the Nove de JulhoUniversity (Sao Paulo, Brazil) and consisted of the collection of clinical data, weight, height, body mass index (BMI), measurements of neck and abdomen circumferences, spirometry, maximum ventilatory pressure measurements, standard overnight polysomnography (PSG) and the administration of the Berlin Questionnaire and Epworth Sleepiness Scale.ResultsFifty-two patients participated in the present study and performed PSG. Out of these, 16 underwent bariatric surgery. After surgery, mean BMI decreased from 48.15 ± 8.58 to 36.91 ± 6.67 Kg/m2. Significant differences were found between the preoperative and postoperative periods regarding neck (p < 0.001) and waist circumference (p < 0.001), maximum inspiratory pressure (p = 0.002 and p = 0.004) and maximum expiratory pressure (p = 0.001 and p = 0.002) for women and men, respectively, as well as sleep stage N3 (p < 0.001), REM sleep (p = 0.049) and the apnea-hypopnea index (p = 0.008).ConclusionsBariatric surgery effectively reduces neck and waist circumference, increases maximum ventilatory pressures, enhances sleep architecture and reduces respiratory sleep disorders, specifically obstructive sleep apnea, in patients with severe obesity.Trial registrationThe protocol for this study was registered with the World Health Organization (Universal Trial Number: U1111-1121-8873) and Brazilian Registry of Clinical Trials – ReBEC (RBR-9k9hhv).

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Effect of Weight Loss After Bariatric Surgery on Left Ventricular Mass and Ventricular Repolarization in Normotensive Morbidly Obese Patients

Cited by 52 publications

References 19 publications

Longitudinal Determinants of Left Ventricular Mass and Geometry

Longitudinal Determinants of Left Ventricular Mass and Geometry

Left-ventricular hypertrophy and obesity

Obstructive sleep apnea and pulmonary function in patients with severe obesity before and after bariatric surgery: a randomized clinical trial

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