Effect of weather and environmental factors on the clinical course of psoriasis: Table 1

Balato, Nicola; Costanzo, Luisa Di; Patruno, Cataldo; Patrì, Angela; Ayala, Fabio

doi:10.1136/oemed-2013-101505

Cited by 49 publications

(39 citation statements)

References 5 publications

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“…For example, patients experience less severe psoriasis and pain in warm, sunny climates (19). Further studies show that pain perception is influenced by psychological distress (e.g.…”

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confidence: 98%

Psoriasis and Skin Pain: Instrumental and Biological Evaluations

Patruno¹,

Napolitano²,

Balato³

et al. 2015

Acta Derm Venerol

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The prevalence of skin pain and the molecular mechanisms responsible for pain in psoriasis remain unclear. This study assessed skin pain in 163 patients (98 males, 65 females, range 18-81 years) with plaque psoriasis, evaluating: the subjective/objective features of this symptom compared with clinical severity of the disease; and the role of interleukin (IL)-33, (involved in both psoriasis and pain pathogenesis), in psoriasis-related pain. Clinical measures used were a questionnaire, plaque Physician Global Assessment (PGA) index, pressure algometry to measure pain threshold and tactile/thermal sensitivity test. IL-33 gene expression was examined in vivo (n = 12) in patients skin and through an ex vivo model of nociception using sodium dodecyl sulphate. Of the psoriatic patients 43.6% reported skin pain during the previous week; itchy, unpleasant, aching, sensitive, hot/burning, tender and cramping were the most reported qualities. Patients' pain threshold decreased with increasing PGA index and pain intensity. Sensitivity to touch/heat was reduced in lesional skin, compared with unaffected psoriatic skin. IL-33 expression was increased in lesional skin of patients reporting pain and in the ex vivo system. In conclusion, symptoms of skin pain should be taken into account in the management of psoriasis.

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“…For example, patients experience less severe psoriasis and pain in warm, sunny climates (19). Further studies show that pain perception is influenced by psychological distress (e.g.…”

mentioning

confidence: 98%

Psoriasis and Skin Pain: Instrumental and Biological Evaluations

Patruno¹,

Napolitano²,

Balato³

et al. 2015

Acta Derm Venerol

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“…Adicionalmente, o clima e a exposição solar afetam a prevalência da psoríase 2 e geralmente observa-se melhoria da dermatose no verão e agravamento no inverno. 5 Esta alteração da sintomatologia com a sazonalidade é explicada pela rápida redução dos marcadores inflamatórios sistémicos e locais após a exposição solar e pelo papel imunossupressor da radiação UVB.…”

Section: Discussionunclassified

“…2 Por outro lado, está também documentado que a psoríase melhora no verão e agrava no inverno em muitos indivíduos. 5 Para além disso, a vitamina D é comprovadamente uma terapêutica eficaz nesta patologia.…”

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Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase

Martins

Bettencourt

Torres

2018

SPDV

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RESUMO -Introdução:A psoríase é uma dermatose imunomediada caraterizada por inflamação crónica, proliferação e diferenciação anormal dos queratinócitos, hiperplasia vascular e infiltração de células inflamatórias. É uma doença multifatorial influenciada por alterações genéticas e epigenéticas despoletadas por estímulos ambientais. O clima e a exposição solar parecem afetar a prevalência da psoríase e a radiação ultravioleta é útil na abordagem terapêutica. O nosso objectivo foi avaliar a influência do mês de nascimento (como marcador da época de gestação) no risco de desenvolver psoríase. Métodos: Comparação da distribuição dos meses de nascimentos nos pacientes com psoríase (n = 755) seguidos no Centro Hospitalar e Universitário do Porto com uma população controlo constituída pelos cidadãos portugueses nascidos no mesmo período e área geográfica dos pacientes com psoríase (n = 6 560 032). Resultados: Observou-se uma diminuição do número de nascimentos de pacientes com psoríase no mês de outubro estatisticamente significativa (OR 0,74; 95% CI 0,55 -0,99; p 0,041). Após correção de Bonferroni e após agrupar os meses por trimestres, não se observaram diferenças estatisticamente significativas. Conclusão: As diferenças estatísticas pouco significativas e não significativas apresentadas podem ser explicadas pelas características meteorológicas particulares de Portugal que podem tornar a síntese de vitamina D relativamente estável durante o ano. A perceção da influência ambiental no desenvolvimento de determinada patologia é importante porque permite o estabelecimento de medidas preventivas que conduzirão à diminuição da sua incidência. PALAVRAS-CHAVE -Estações; Factores de Risco; Luz Solar; Psoríase; Raios Ultravioleta; Vitamina D. (OR 0.74; p 0.041 Effect of Month of Birth on the Risk of Developing Psoriasis ABSTRACT -Introduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis. Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032). Results: Birth rate of psoriasis patients decreased in October INTRODUÇÃOA psoríase é uma dermatose imunomediada caracterizada por inflamação crónica, proliferação e diferenciação anormal dos queratinócitos, hiperplasia vascular e infiltração de células inflamatórias na derme e epiderme.1,2 Afeta cerca de 2% da população mundial e, assim como outras doenças autoimunes (DAI), resulta da...

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“…Geographic variations and climatic factors such as sun exposure and humidity could influence the prevalence of psoriasis and explain (among other factors) the variability of disease incidence all over the world (16). Work-related physical activity is proved to be correlated with onset of psoriatic arthritis (17).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Psoriasis and Specific Professional Activities or Occupation-Induced Skin Diseases

et al. 2014

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Background: Psoriasis is a systemic, immune-mediated disease, associated with significant comorbidities, with a high negative impact on the quality of life. Objectives: The aim of this study was to evaluate the profession of patients diagnosed with psoriasis and establish a correlation between the disease and occupation. Patients and Methods:In an outpatient clinic, 1236 patients were diagnosed with psoriasis during eight years (2004-2011) and followed up for different clinical parameters and details in their working places. Results: Of 1236 patients, 669 were male (54.13%) and 567 (45.87%) female, with a predominance of male over female (1.18/1); the median age at diagnosis was 29.34 ± 15.24; the retired individuals were mostly representatives (149, 12.6%), followed by pupils (112, 9.06%), employees (108, 8.74%), engineers (87, 7.04%), students (70, 5.66%), managers (56, 4.53%), housewives (54, 4.37%), professors (53, 4.28%), drivers (46, 3.72%), salesmen (39, 3.16%), economists (38, 3.07%), healthcare professionals (32, 2.59%). Others were unemployed (71 -8.77%) or had other occupations. Conclusions:The results did not conclusively declare psoriasis as an occupational or occupational-induced disease.

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Effect of weather and environmental factors on the clinical course of psoriasis: Table 1

Cited by 49 publications

References 5 publications

Psoriasis and Skin Pain: Instrumental and Biological Evaluations

Psoriasis and Skin Pain: Instrumental and Biological Evaluations

Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase

The Relationship Between Psoriasis and Specific Professional Activities or Occupation-Induced Skin Diseases

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