Effect of water on the oxygen barrier properties of poly(ethylene terephthalate) and polylactide films

Auras, Rafael; Harte, Bruce; Selke, Susan

doi:10.1002/app.20148

Cited by 155 publications

(101 citation statements)

References 31 publications

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“…Because PLA is permeable to oxygen, response times can be fast. 42,43 PLA nanoparticles are known to degrade over 2 years time because of acid-catalyzed ester hydrolysis. The polymer molecular weight decreases slowly for 5 weeks, then more rapidly thereafter.…”

Section: Resultsmentioning

confidence: 99%

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

et al. 2008

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Difluoroboron dibenzoylmethane-polylactide, BF 2 dbmPLA, a biocompatible polymerluminophore conjugate was fabricated as nanoparticles. Spherical particles <100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon absorption, and long-lived room temperature phosphorescence (RTP) are retained in aqueous suspension. The nanoparticles were internalized by cells and visualized by fluorescence microscopy. Luminescent boron biomaterials show potential for imaging and sensing.Keywords boron dye; fluorescence; phosphorescence; poly(lactic acid) (PLA); nanoparticles Difluoroboron-based dyes, such as BODIPY 1 and β-diketonate derivatives, 2 exhibit large extinction coefficients, high emission quantum yields, large two-photon absorption crosssections, and in some cases, sensitivity to the surrounding medium. 3 These exceptional optical properties make them useful as imaging agents, 4 photosensitizers, 5 and sensors. 6 Often dyes are combined with material substrates to modulate properties, enhance stability, and reduce toxicity. Dye leaching with associated toxicity and ambiguity in imaging and sensing schemes can be minimized with dye-polymer conjugates versus blends. 7 For example, active agents such as Ru(II) complexes 8,9 or metalloporphyrins 10 are embedded in polymer matrices that act as protective shells and allow their use in biological contexts with increased stability and improved delivery 11,12 by passive 13,14 or active targeting. 15 Many multifunctional imaging and sensing agents combine controlled material synthesis with nanofabrication. 16,17 Nanoparticles based on luminescent dye conjugates and quantum dots 18 are used to label intracellular structures and pathways in fundamental studies as well as for therapeutic and diagnostic purposes. 19,20 Both fluorescence (singlet) and phosphorescence (triplet) emitters are widely used. Phosphorescence, in particular, is susceptible to oxygen quenching via triplet energy transfer, serving as the basis for oxygen sensing. 21-23 Good oxygen permeability and fast response time are important factors. Photodynamic therapy, on the other hand, utilizes photosensitizers in combination with oxygen or other quenchers to generate reactive species for selective tissue treatment. 24-26Previously we reported that when boron difluoride dibenzoylmethane (BF 2 dbm) is combined with poly(lactic acid) (PLA), a biocompatible polymer, 27 the intense blue fluorescence is retained and new properties emerge, namely temperature-sensitive delayed fluorescence and * Address correspondence to fraser@virginia.edu. NIH Public Access RESULTS AND DISCUSSIONDifluoroboron dibenzoylmethane polylactide, BF 2 dbmPLA (Figure 1), was synthesized by ring opening polymerization of lactide using a hydroxyl-functionalized BF 2 dbm initiator and tin catalyst as previously described. 28 Nanoparticles were produced by the solvent displacement method (i.e., nanoprecipitation) 29,30 in which the polymer is dissolved in a solvent miscible with water (e.g., DMF) (oil phase),...

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Section: Resultsmentioning

confidence: 99%

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

et al. 2008

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“…PLA processed barrier properties that were higher than those of PE, PP and similar to PS but lower than those of PET ( Figure 10). Auras and coworkers [50,51] studied the barrier properties of PLA and compared them with those of PET and PS. They showed that the permeability coefficients of CO 2 , O 2 , N 2 , and H 2 O (g) for PLA were lower than that of PS, but higher than that of PET.…”

Section: Barrier Propertiesmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

573

306

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Abstract. Polylactic acid (PLA), one of the well-known biodegradable polyesters, has been studied extensively for tissue engineering and drug delivery systems, and it was also used widely in human medicine. A new method to synthesize PLA (ring-opening polymerization), which allowed the economical production of a high molecular weight PLA polymer, broadened its applications, and this processing would be a potential substitute for petroleum-based products. This review described the principles of the polymerization reactions of PLA and, then, outlined the various materials properties affecting the performance of PLA polymer, such as rheological, mechanical, thermal, and barrier properties as well as the processing technologies which were used to fabricate products based on PLA. In addition, the biodegradation processes of products which were shaped from PLA were discussed and reviewed. The potential applications of PLA in the medical fields, such as tissue engineering, wound management, drugs delivery, and orthopedic devices, were also highlighted.

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“…We suggest that this behaviour might be caused by the different chirality of the Biophan  sample, because the crystallization kinetics are strongly dependent on the D-and L-content of the copolymer. 29 Solvent-induced crystallization has already been described for the semi-crystalline polyester PET, 40,46 -48 in particular by Serad et al 40 and by Ouyang et al 48 who showed the crystallization of PET in contact with acetaldehyde and acetone, respectively. Ouyang and Shore 49,50 showed for the solvent-induced phenomenon that the sample dimensions increased after the sorption of the solvent due to swelling of the polymer.…”

Section: Samplementioning

confidence: 99%

Barrier properties of poly(lactic acid) and its morphological changes induced by aroma compound sorption

Colomines

Ducruet

Courgneau

et al. 2010

Polymer International

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properties of poly(lactic acid) and its morphological changes induced by aroma compound sorption. Polymer International, Wiley, 2010Wiley, , 59 (6), pp.818-826. 10.1002Wiley, /pi.2793 Barrier properties of poly(lactic acid) and its morphological changes induced by aroma compound sorption Gael Colomines, a Violette Ducruet, b Cécile Courgneau, b Alain Guinault a and Sandra Domenek b * The barrier properties of poly(lactic acid) (PLA) play a key role in food packaging applications. For their optimization, the influence of crystallinity on the barrier properties of PLA and the interaction of PLA with the aroma compound ethyl acetate were investigated. PLA film samples with various crystallinities were fabricated by flat die extrusion and thermocompression and compared to PLA Biophan  . The degree of crystallinity had no effect on the oxygen permeability. However, an increase of crystallinity caused a decrease in ethyl acetate sorption. The sorption isotherm of ethyl acetate obtained using microgravimetry showed a steep increase with increasing aroma activity, a form which is consistent with a plasticization effect. This behaviour was verified using differential scanning calorimetry and dynamic mechanical analysis. Sorption caused a marked decrease in the glass transition temperature well below room temperature to approximately 0• C. Furthermore, PLA underwent a solvent-induced crystallization when equilibrated in ethyl acetate atmosphere at an activity of 0.5. The results obtained show the importance of considering possible interactions between polymer and foodstuff during the optimization step of polymeric materials for food packaging applications.

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Effect of water on the oxygen barrier properties of poly(ethylene terephthalate) and polylactide films

Cited by 155 publications

References 31 publications

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

Properties and medical applications of polylactic acid: A review

Barrier properties of poly(lactic acid) and its morphological changes induced by aroma compound sorption

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