Effect of water-matrix composition on Trimethoprim solar photodegradation kinetics and pathways

Sirtori, Carla; Agüera, Ana; Gernjak, Wolfgang; Malato, Sixto

doi:10.1016/j.watres.2010.02.006

Cited by 171 publications

(90 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MS/MS experiments with OP306 using a collision energy of 30 eV gave the product ions shown in Table 1. Transformation products of TRI with the same molecular formula, number of exchangeable hydrogens, precursor ion and product ions (Table 1) have been previously reported by several authors and were produced by rat metabolism [32], pig liver microsomes [33] and diverse water treatment processes [16,18,19,22]. Proposed structures are shown in Figure 2 (isomers A, B and C).…”

Section: Cyclic Voltammetry and Electrolysissupporting

confidence: 59%

“…Those compounds can cause signal suppression, thus avoiding detection of minor sample components. The TRI oxidation product α-OH-TRI has been observed in living systems such as rat metabolism [32], and biological and chemical process like nitrifying bacteria in activated sludge [22], direct photolysis and solar TiO 2 photocatalysis [16], oxidation by KMnO 4 [18] and thermo-activated persulfate oxidation [19]. This demonstrates the diversity of phenomena in which electrochemistry can play an important role in predicting, identifying and understanding the formation of transformation products of EOCs generated by diverse and dissimilar systems involving redox reactions.…”

Section: Cyclic Voltammetry and Electrolysismentioning

confidence: 99%

See 1 more Smart Citation

Electrochemistry-High Resolution Mass Spectrometry to Study Oxidation Products of Trimethoprim

et al. 2018

View full text Add to dashboard Cite

Abstract:The study of the fate of emerging organic contaminants (EOCs), especially the identification of transformation products, after water treatment or in the aquatic environment, is a topic of growing interest. In recent years, electrochemistry coupled to mass spectrometry has attracted a lot of attention as an alternative technique to investigate oxidation metabolites of organic compounds. The present study used different electrochemical approaches, such as cyclic voltammetry, electrolysis, electro-assisted Fenton reaction coupled offline to high resolution mass spectrometry and thin-layer flow cell coupled online to high resolution mass spectrometry, to study oxidation products of the anti-infective trimethoprim, a contaminant of emerging concern frequently reported in wastewaters and surface waters. Results showed that mono-and di-hydroxylated derivatives of trimethoprim were generated in electrochemically and possibly tri-hydroxylated derivatives as well. Those compounds have been previously reported as mammalian and bacterial metabolites as well as transformation products of advance oxidation processes applied to waters containing trimethoprim. Therefore, this study confirmed that electrochemical techniques are relevant not only to mimic specific biotransformation reactions of organic contaminants, as it has been suggested previously, but also to study the oxidation reactions of organic contaminants of interest in water treatment. The key role that redox reactions play in the environment make electrochemistry-high resolution mass spectrometry a sensitive and simple technique to improve our understanding of the fate of organic contaminants in the environment.

show abstract

Section: Cyclic Voltammetry and Electrolysissupporting

confidence: 59%

Section: Cyclic Voltammetry and Electrolysismentioning

confidence: 99%

Electrochemistry-High Resolution Mass Spectrometry to Study Oxidation Products of Trimethoprim

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Solar photodegradation is known to be dependent on factors such as light intensity, water matrix, season and latitude. [58] Photocatalysis and photolysis of DCF using a loop reactor The laboratory-scale Laboclean reactor was used for the photochemical and photocatalytic degradation of DCF in DW and TW (Fig. 2).…”

Section: Effect Of Cooling Jacket Materials and Tio 2 Typementioning

confidence: 99%

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Kanakaraju¹,

Cherie²,

Motti³

et al. 2014

Environ. Chem.

View full text Add to dashboard Cite

Environmental context. Diclofenac, a common non-steroidal anti-inflammatory drug, is not completely removed from surface and drinking water by conventional treatment methods. Consequently, this drug is present in the aquatic environment and has been subsequently linked to toxic effects on organisms. We show that photolysis and TiO 2 -catalysed degradation in circulating batch reactors efficiently results in diclofenac removal under a variety of conditions. These photochemical methods thus may lead to more effective water treatment processes.Abstract. The occurrence of diclofenac (DCF) as an emerging pollutant in surface waters and drinking water has been attributed to elevated global consumption and the inability of sewage treatment plants to remove DCF. In this study, DCF spiked drinking water and river water was subjected to photolysis and TiO 2 photocatalytic treatments in a circulating laboratory-scale (immersion-well) and a demonstration-scale loop reactor (Laboclean). The operational parameters for the immersion-well reactor were optimised as follows: TiO 2 P25 loading, 0.1 g L À1 ; natural pH, 6.2; initial concentration, 30 mg L À1 ; water type, distilled water. Complete DCF removal was realised within 15 min under the optimised conditions using the immersion-well reactor. Sunlight-mediated photochemical degradation required a prolonged exposure period of up to 360 min for complete DCF removal. DCF in distilled and drinking water was efficiently degraded in the larger Laboclean reactor. Differences were, however, observed based on their pseudo-first-order rate constants, which implies that the water matrix has an effect on the degradation rate. Six major photoproducts, 2-(8-chloro-9H-carbazol-1-yl)acetic acid, 2-(8-hydroxy-9H-carbazol-1-yl)acetic acid, 2,6-dichloro-N-o-tolylbenzenamine, 2-(phenylamino)benzaldehyde, 1-chloromethyl-9H-carbazole and 1-methyl-9H-carbazole, generated from TiO 2 photocatalysis of DCF were identified by liquid chromatography-mass spectrometry (LCMS) and Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS). This work has shown that photocatalytic degradation kinetics of DCF are dependent on both the geometry of the photoreactor and the nature of the water matrices.

show abstract

“…Trimethoprim photo-degradation studies in saltwater indicate "only a small increase" in the toxicity on test organisms, with intermediates which were moderately toxic for the organisms tested (Sirtori et al 2010, Fatta-Kassinos et al 2011). Thus SMX is degrading more quickly (with its shorter half-life), and potentially with more toxic degradation products.…”

Section: Discussionmentioning

confidence: 99%

“…Trimethoprim photo-degradation studies in saltwater, though limited, indicate "only a small increase" in the toxicity on test organisms, with intermediates which were moderately toxic for the organisms tested (Sirtori et al 2010, Fatta-Kassinos et al 2011). Toxicity as well as sub-lethal assessments of transformation products must be included in the suite of pharmaceutical contaminant research to more closely simulate environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations

Teixeira¹

View full text Add to dashboard Cite

Approximately 48% of Americans use prescription drugs within each 30-day period, and there are signs this trend is increasing. Although many studies track pharmaceuticals' fates in contaminating waterways, only fairly recent efforts have examined the potential impacts of these drugs on non-target organisms. The antibiotics sulfamethoxazole and trimethoprim, often prescribed together to treat bacterial infections, have been detected worldwide in marine and estuarine environments at concentrations up to 700-800 ng/L each. Toxic effects of these drugs have been identified in freshwater organisms, with synergistic effects observed in short-term studies of mixtures of the two; however, little research has examined possible sub-lethal and longer-term effects of antibiotics in environmentally-relevant mixture concentrations on marine organisms. I examined the long-term effects of mixtures of these two antibiotics in species of a marine system: marine microalgal species, and marine mussels, to determine whether the levels currently present in waterways affect organism health and reproduction.Microalgal species may be among the most sensitive organisms to pharmaceutical contaminants based on ecotoxicity research. I exposed three species of marine microalgae (Isochrysis galbana, Chaetoceros neogracile, and Nannochloropsis oculata) to environmentally-relevant mixtures of sulfamethoxazole and trimethoprim and examined their three-week growth rates. I found that for each species, the antibiotic treatments significantly suppressed algal growth. Specifically, I found that sulfamethoxazole was a driving factor in suppression of C. neogracile and I. galbana growth, while N. oculata responded more sensitively to a broader range of treatment mixture levels, which also ii included trimethoprim-only treatment groups and mixtures. These results on marine microalgae address critical data gaps, and identify the impacts of pharmaceuticals on marine primary producers, which could have direct ecosystem implications to higher trophic levels.Antibiotic pharmaceuticals can also affect marine mussel health, based on previous study of sub-cellular endpoints. I hypothesized that the important benthic foundational species, the Mytilus californianus mussel, would be significantly impacted by long-term 12-week exposure to environmentally-relevant concentrations and mixtures of sulfamethoxazole and trimethoprim. Specifically, I measured growth rate, feeding rate, condition index, and gonando-somatic index as indicators of whole-organism and reproductive health. Sulfamethoxazole concentrations, in particular, and trimethoprim to a lesser extent, suppressed mussel growth and significantly affected condition index and gonandosomatic index over time. The results of this study offer an understanding of how an intertidal system responds to chronic presence of antibiotic mixtures in the water, and a more complete picture of the environmental consequences of pharmaceutical contaminants released into marine ecosystems at ever-growing rates.iii ACKNO...

show abstract

Effect of water-matrix composition on Trimethoprim solar photodegradation kinetics and pathways

Cited by 171 publications

References 37 publications

Electrochemistry-High Resolution Mass Spectrometry to Study Oxidation Products of Trimethoprim

Electrochemistry-High Resolution Mass Spectrometry to Study Oxidation Products of Trimethoprim

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations

Contact Info

Product

Resources

About