Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs

Yıldırım, Zeki; Hacievlıyagıl, Süleyman Savaş; Kutlu, Nurettin Onur; Aydın, Engin; Kürkçüoğlu, Mine; Iraz, Mustafa; Durmaz, Rıza

doi:10.1016/j.phrs.2003.10.007

Cited by 53 publications

(36 citation statements)

References 22 publications

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“…Oxygenated hydrocarbons, oxygenated sesquiterpenes, aromatic alcohols and esters were the main aroma-active constituent in North Eastern Anatolian samples [41]. Distinct volatile composition was determined for propolis sample from South Eastern Anatolia (Malatya), in which monoterpenes (α-terpinene and α-terpineol) were the most abundant constituents [42]. …”

Section: Reviewmentioning

confidence: 99%

Propolis volatile compounds: chemical diversity and biological activity: a review

Bankova

Popova

Trusheva

2014

Chemistry Central Journal

278

248

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Propolis is a sticky material collected by bees from plants, and used in the hive as building material and defensive substance. It has been popular as a remedy in Europe since ancient times. Nowadays, propolis use in over-the-counter preparations, “bio”-cosmetics and functional foods, etc., increases. Volatile compounds are found in low concentrations in propolis, but their aroma and significant biological activity make them important for propolis characterisation. Propolis is a plant-derived product: its chemical composition depends on the local flora at the site of collection, thus it offers a significant chemical diversity. The role of propolis volatiles in identification of its plant origin is discussed. The available data about chemical composition of propolis volatiles from different geographic regions are reviewed, demonstrating significant chemical variability. The contribution of volatiles and their constituents to the biological activities of propolis is considered. Future perspectives in research on propolis volatiles are outlined, especially in studying activities other than antimicrobial.

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Section: Reviewmentioning

confidence: 99%

Propolis volatile compounds: chemical diversity and biological activity: a review

Bankova

Popova

Trusheva

2014

Chemistry Central Journal

278

248

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“…In the last years, this product has been the subject of intensive studies, highlighting its biological and pharmacological properties, such as the antimicrobial [3], antioxidative, antihepatotoxic [4], antitumoral, antiinflammatory [5], anti-HIV-1 [6], antineurodegenerative [7], and antituberculosis [8]. Propolis was also tested as food preserver due to its bactericidal and bacteriostatic properties [9].…”

Section: Introductionmentioning

confidence: 99%

Phenolic characterization of Northeast Portuguese propolis: usual and unusual compounds

et al. 2009

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In this study, an ethanolic extract from Portuguese propolis was prepared, fractionated by highperformance liquid chromatography, and the identification of the phenolic compounds was done by electrospray mass spectrometry in the negative mode. This technical approach allowed the identification of 37 phenolic compounds, which included not only the typical phenolic acids and flavonoids found in propolis from temperate zones but also several compounds in which its occurrence have never been referred to in the literature. Four of the novel phenolic compounds were methylated and/or esterified or hydroxylated derivatives of common poplar flavonoids, although six peculiar derivatives of pinocembrin/pinobanksin, containing a phenylpropanoic acid derivative moiety in their structure, were also identified. Furthermore, the Portuguese propolis sample was shown to contain a p-coumaric ester derivative dimer.

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“…Propolis has a long history of use in folk medicine and is a popular remedy today to treat a variety of ailments (Castaldo and Capasso, 2002). Several scientifi c studies have documented the antimicrobial activity of its extracts and, in particular, its antitubercular (Yildirim et al, 2004), antifungal (Ota et al, 2001) and antibacterial effect on Gram-positive microorganisms such as Staphylococccus aureus (Fernandes Júnior et al, 2005). In vitro susceptibility tests have also revealed that propolis could synergize the effect of selected antibiotics against S. aureus isolates (Fernandes Júnior et al, 2005;Scazzocchio et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antimethicillin‐resistant Staphylococcus aureus (MRSA) activity of ‘pacific propolis’ and isolated prenylflavanones

Raghukumar

Vali

Watson

et al. 2010

Phytotherapy Research

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The need to discover and develop alternative therapies to treat methicillin-resistant Staphylococcus aureus (MRSA) infections is timely. This study was undertaken to purify and identify some anti-MRSA constituents from propolis, a natural product from the beehive traditionally used in folk medicine for its antimicrobial properties. A crude extract of propolis originating from the Solomon Islands ('Pacific propolis') was screened, using an agar dilution assay, in vitro against 15 MRSA clinical isolates. Results revealed activity worthy of further investigation, and subsequent purification work on this crude extract afforded 23 fractions. Further purification of active fractions led to the isolation of compounds 1-4, characterized upon analysis of their spectroscopic data (1D- and 2D-NMR, MS) and by comparison with the literature, as the prenylflavanones propolin H (1), propolin G (2), propolin D (3), and propolin C (4). This study is the first to report the anti-MRSA activity of 'Pacific propolis' and the presence of prenylflavanones in the propolis sample selected. The anti-MRSA activity of propolin D (3) (MIC 8-16 mg/L) and propolin C (4) (MIC 8-32 mg/L) is reported for the first time.

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Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs

Cited by 53 publications

References 22 publications

Propolis volatile compounds: chemical diversity and biological activity: a review

Propolis volatile compounds: chemical diversity and biological activity: a review

Phenolic characterization of Northeast Portuguese propolis: usual and unusual compounds

Antimethicillin‐resistant Staphylococcus aureus (MRSA) activity of ‘pacific propolis’ and isolated prenylflavanones

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