Effect of Washed Microbiota Transplantation on Patients With Dyslipidemia in South China

Abstract

Background and AimsAlthough the manual crude fecal microbiota transplantation (FMT) reduces blood lipids in animal models of hyperlipidemia, its clinical effect on blood lipid metabolism in patients with hyperlipidemia and hypolipidemia remains unclear, especially in the Chinese population. It was reported that washed microbiota transplantation (WMT) was safer, more precise, and more quality-controllable than the crude FMT by manual. This study aimed to investigate the feasibility and effectiveness of WMT on lipid metabolism in the Chinese population.MethodsClinical data of patients with various indications who received WMT for 1–3 treatment procedures were collected. Changes in blood lipids before and after WMT, namely, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), homeostasis model assessment of insulin resistance (HOMA-IR), liver fat attenuation, and liver stiffness measurement, were compared.ResultsA total of 177 patients (40 cases of hyperlipidemia, 87 cases with normal blood lipids, and 50 cases of hypolipidemia) were enrolled in the First Affiliated Hospital of Guangdong Pharmaceutical University. WMT has a significant therapeutic effect in reducing blood lipid levels (TC and TG) in the short- and medium term in patients with hyperlipidemia (p <0.05). Hyper blood lipid decreased to normal in the short-term (35.14%; p <0.001), and LDL-C changed to normal in the medium term (33.33%; p = 0.013). In the hypolipidemia group, 36.36% and 47.06% changed to normal in the short-term (p = 0.006) and medium term (p = 0.005) of therapeutic effects based on blood lipid levels. In the normal blood lipid group and the low-risk group of atherosclerotic cardiovascular disease (ASCVD), the change was not statistically significant, indicating that WMT does not increase the risk of blood lipid and ASCVD in the long-term.ConclusionsWMT treatment changes blood lipids in patients with hyperlipidemia and hypolipidemia without serious adverse events, with no risk for increasing blood lipids and ASCVD in the long-term. There were significant decreased TC, TG, and LDL-C levels in the medium term of WMT treatment for hyperlipidemia. Therefore, the regulation of gut microbiota by WMT may indicate a new clinical method for the treatment of dyslipidemia.

Washed microbiota transplantation improves patients with high blood glucose in South China

“…A scientific and reasonable T2DM treatment strategy should be comprehensive, including control of blood glucose, blood pressure, blood lipids, and body weight, antiplatelet therapy, and lifestyle improvements. Although there are several studies on WMT function, such as Liang et al showed that WMT treatment can alter blood lipids in patients with hyperlipidemia and hypolipidemia without serious adverse events (48). Studies by Zhong et al have shown that WMT has antihypertensive effects in hypertensive patients (49).…”

Washed microbiota transplantation improves patients with metabolic syndrome in South China

“…Although there were several studies on WMT function, such as Liang et al. showed that WMT treatment could alter blood lipids in patients with hyperlipidemia and hypolipidemia without serious adverse events ( Liang et al., 2022 ). Wu et al.…”

Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota

“…For example, colonization of mice with microbiota from donors with dyslipidemia resulted in increased intestinal cholesterol absorption and a hypercholesterolemic phenotype when compared to mice colonized with normal microbiota [ 23 ]. Similarly in humans, washed microbiota treatment has been shown to reduce serum cholesterol in dyslipidemia patients [ 24 ]. Further, using germ-free animal models, it has been shown that the effects of dietary fats on the host physiology and metabolism are dependent on the gut microbiota.…”