Effect of VKORC1 –1639 G&gt;A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients

Yoshizawa, Misa; Hayashi, Hideki; Tashiro, Yoshio; Sakawa, Sonoko; Moriwaki, Hisataka; Akimoto, Takehide; Doi, Osamu; Kimura, Midori; Kawarasaki, Yoshinori; Inoue, Ken‐ichiro; Itoh, Ken

doi:10.1016/j.thromres.2008.11.011

Cited by 53 publications

(35 citation statements)

References 29 publications

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“…Our findings are in concordance with previous studies carried on a Japanese [14], Chinese [41] and Indonesian population [23]. This is in contrast to other reports [7][8][9].…”

Section: Discussionsupporting

confidence: 92%

“…Two single nucleotide polymorphisms (SNPs) of VKORC1 were found to estimate warfarin dosing phenotypes: -1639G[A (rs9923231) promoter polymorphism and 1173C[T (rs9934438) intronic polymorphism [9]. Studies of white and Asian patients have reported that CYP2C9 and VKORC1 polymorphisms influence the maintenance dose of warfarin [14,15], but they appear to contribute to less than half of the inter-individual variability in the doseresponse relationship to oral anticoagulants [14]. Several warfarin dosing algorithms have been proposed to tailor the warfarin dosing in the European, Asian and AfricanAmerican populations.…”

Section: Introductionmentioning

confidence: 99%

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Validation of a Proposed Warfarin Dosing Algorithm Based on the Genetic Make-Up of Egyptian Patients

et al. 2013

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VKORC1 (1173C>T) contributes to the warfarin dose variability. Patients' age and genetic variants of VKORC1 account for nearly 20.5% of the variability in warfarin dose required to achieve an INR of 2-3. The success of a prediction equation based on these variables was proved in a different cohort: the predicted dose correlated significantly with the maintenance dose and the equation was more successful among patients with a dose≥35 mg/week. The results of the warfarin algorithm we developed were comparable with those of the IWPC and Gage algorithms with the advantage of using one SNP (VKORC1 1173C>T) only. This represents an economic advantage in our community. Replication of this study in a larger cohort of patients is necessary before translation of this knowledge into clinical guidelines for warfarin prescription.

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“…Our findings are in concordance with previous studies carried on a Japanese [14], Chinese [41] and Indonesian population [23]. This is in contrast to other reports [7][8][9].…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Validation of a Proposed Warfarin Dosing Algorithm Based on the Genetic Make-Up of Egyptian Patients

et al. 2013

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“…A study conducted by Yoshizawa et al showed that polymorphism CYP2C9 and vitamin K epoxide reductase complex subunit 1 (VKORC1) contribute helpfully to warfarin's efficacy and toxicity. CYP2C9 was an enzyme that was useful for warfarin metabolism, while VKORC1 was a target gene where warfarin works [11]. According to the result of a study about pharmacogenetic conducted by Taofik et al toward population of Indonesian who use warfarin, exemplifies that age and genetical variation of CYP2C9 and VKORC1 influences warfarin response, namely, the result of PT-INR, index of pharmacodynamic, index of pharmacokinetics, and S-warfarin concentration on patients who consume low-dosage warfarin (1 mg).…”

Section: Discussionmentioning

confidence: 99%

Effects of Pharmacist Counseling on Compliance and Inr Score on Outpatients Receiving Warfarin at Dr. Hasan Sadikin Bandung Hospital West Java, Indonesia

Putriana

Lestari

Barliana

et al. 2017

Asian J Pharm Clin Res

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Objective: Warfarin is a derivate of coumarin, which is usually prescribed as an oral anticoagulant for treatment and prevention of thromboembolic disorders. The aim of present research is to analyze the influence of pharmacist counseling on compliance and international normalized ratio (INR) score recovery on warfarin management. Methods:Design in this research used mixed method, combination of qualitative and quantitative method. Qualitative data were used for completing quantitative data. Qualitative method used a content analysis with interview. Quantitative method used a quasi-experimental method with control groups, pre-test, and post-test design. Data were analyzed by Wilcoxon test and Mann-Whitney test at significance level p≤0.05 and multivariate analysis covariate.Results: Data were collected from 80 patients with rheumatic heart disease (42.5%), atrial fibrillation (17.5%), deep vein thrombosis (10%), rheumatic mitral valve disease (10%), prosthetic heart (7.5%), other (22.5%). The numbers of patients whose INR was in the therapeutic range for each indication was not statistically different between before and after receiving counseling (p>0.05), Patients' behavior compliance of warfarin therapy had increased after receiving the counseling service (p<0.05). The result of presents research is pharmacist counseling affected behavior compliance before and after counseling (p<0.05) but not for INR (p>0.05). Conclusion:Pharmacist counseling can improve behavior compliance but not improve INR target. The effect of warfarin to every individual not only affected by behavior compliance but also several factors could influence effect of warfarin is clinical factors, non-clinical factors, and genetic factors. Clinical factors that were influenced were age, gender, pharmacokinetic and pharmacodynamic variability in patients.

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“…Inter-individual variability in dose response to warfarin is associated with various demographic, clinical, and genetic factors [20]. A number of algorithms have been developed to quantitatively predict the maintenance dose of warfarin in multiple ethnicities [21,22] including Japanese [23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Effect of impaired renal function on the maintenance dose of warfarin in Japanese patients

Ichihara

Ishigami

Umemura

2015

Journal of Cardiology

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Effect of VKORC1 –1639 G>A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients

Cited by 53 publications

References 29 publications

Validation of a Proposed Warfarin Dosing Algorithm Based on the Genetic Make-Up of Egyptian Patients

Validation of a Proposed Warfarin Dosing Algorithm Based on the Genetic Make-Up of Egyptian Patients

Effects of Pharmacist Counseling on Compliance and Inr Score on Outpatients Receiving Warfarin at Dr. Hasan Sadikin Bandung Hospital West Java, Indonesia

Effect of impaired renal function on the maintenance dose of warfarin in Japanese patients

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