Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium

Acharya, Usha; Mishra, Monalisa; Patro, Jhunita; Panda, Manoj

doi:10.1016/j.reprotox.2007.10.004

Cited by 189 publications

(153 citation statements)

References 40 publications

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“…However, others reported a significant increase in testis weight after CCl 4 administration which may be attributed to the different treatment times and dosage (20). There is a direct association between the epididymal sperm count, extent of spermatogenesis, and fertility in animals (2,14). Sperm parameters such as count, motility, and viability are the key indices of male fertility, as these are the prime markers in testicular spermatogenesis, epididymal maturation, and sperm fertilization capacity (30).…”

Section: Sperm Parametersmentioning

confidence: 99%

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

et al. 2016

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The increased generation of free radicals plays an important role in testicular damage. The present study aimed to investigate the adverse effects of carbon tetrachloride (CCl 4 ) on the reproductive system of male rats as well as to examine whether Vitamin E (VE) is able to ameliorate these effects. The rats were equally divided into three groups: control, CCl 4 -treated, and CCl 4 + VE-treated groups. After 4 weeks of treatment, the decrease in body and testes weights, sperm parameters, and the decrease in serum levels of testosterone, luteinizing hormone, and folliclestimulating hormone of CCl 4 -treated rats were ameliorated by VE treatment. The co-administration of VE with CCl 4 significantly decreased the level of lipid peroxidation production (malondialdehyde) and increased the activity of anti-oxidant enzymes (superoxide dismutase and catalase) when compared with the CCl 4 group. Moreover, VE prevented CCl 4 -induced severe testicular histopathological lesions and deformities in spermatogenesis. The results demonstrate that VE augments the anti-oxidants' defense mechanism against CCl 4 -induced reproductive toxicity suggesting a therapeutic role in free radical-mediated infertility.

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Section: Sperm Parametersmentioning

confidence: 99%

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

et al. 2016

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“…Moreover, there was an increase in the total number of malformed sperms. Generation of reactive oxygen species (ROS) by Cd-toxicity and resultant oxidative impairment may increase the meiotic errors and sperm deformation (Acharya et al, 2008). Studies have designated that the exposure to Cd initiates lipid peroxidation, which leads to oxidative stress (Ji et al, 2012;Zhang et al, 2012).…”

Section: Discussion:-mentioning

confidence: 99%

Ameliorative Potential of Moringa or Quercetin on Cadmium Induced Testicular Toxicity in Adult Male Rats.

ElNahrawy.¹

2017

IJAR

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“…On the other hand, there are reports showing that vitamin C enhances the activities of anti-oxidant enzymes and has positive effects on some diseases. Examples include the increase of CAT activity and the inhibition of lipid peroxidation in the brains of rats subjected to pilocarpine-induced convulsion (32), and the increase of CAT and Cu/ZnSOD activities and the inhibitions of sperm number decrease, abnormal sperm formation and lipid peroxidation in cadmium-treated mice (33).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Intake of High Doses of Vitamin C Down-regulates Anti-oxidant Enzymes in Human Erythrocytes

Kim¹,

Park²,

Rhee³

et al. 2008

JFN

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We located a group of healthy young males (aged 20～30) who had been taking a high dose (more than 5 g) of vitamin C daily for more than one year. We observed that this vitamin C group had plasma levels of vitamin C that were more than three times that of the control group. The control group had not taken any additional vitamin C except for that included in their diets. But the vitamin C group showed significantly lower amounts of Cu/ZnSOD, catalase and glutathione-s-transferase and lower activities of glutathione peroxidase and glutathione reductase in erythrocyte lysates than the control group. However, there was no difference in the plasma levels of lipid peroxides between the two groups. These results suggest that vitamin C offsets its own contribution to anti-oxidant activity by repressing the expression of anti-oxidant enzymes and also excludes the possibility that vitamin C acts as a pro-oxidant in vivo.

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Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium

Cited by 189 publications

References 40 publications

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

Ameliorative Potential of Moringa or Quercetin on Cadmium Induced Testicular Toxicity in Adult Male Rats.

Long-Term Intake of High Doses of Vitamin C Down-regulates Anti-oxidant Enzymes in Human Erythrocytes

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