Effect of vitamin E succinate on expression of TGF-β<sub>1</sub>, c-Jun and JNK1 in human gastric cancer SGC-7901 cells

Wu, Kun; Liu, Bai He; Zhao, Dan; Zhao, Yan

doi:10.3748/wjg.v7.i1.83

Cited by 20 publications

(1 citation statement)

References 31 publications

(11 reference statements)

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“…A number of studies have explored the JNK signaling pathway in gastric cancer. When SGC-7901 cells were treated with vitamin E succinate, transforming growth factor-β was activated, which in turn increased the activity of JNK, which then induced c-Jun phosphorylation; finally, p-c-Jun initiated apoptosis of gastric cancer cells (19). Similarly, the antioxidant analogue α-tocopheryl succinate induced apoptosis by activating ERK1/2 and JNK via c-Jun in the gastric cancer cell line SGC-7901 (20).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of non-muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c-Jun N-terminal kinase signaling pathway

Liu

Zhang

et al. 2015

Molecular Medicine Reports

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Non‑muscle myosin IIA (NMIIA) has been found to be overexpressed in gastric cancer tissues. However, the roles of NMIIA in the migration and invasion of gastric cancer cells have not yet been elucidated. The aim of the present study was to assess the effects of NMIIA knockdown on the migratory and invasive capacities of gastric cancer cells and to investigate the potential underlying mechanisms in vitro. First, the expression of NMIIA was assessed in gastric cancer tissues and non‑cancerous tissues using western blot analysis. The expression levels of NMIIA protein in 51 out of 63 gastric cancer tissue specimens were higher compared to those in their matched non‑tumoric gastric tissue specimens, and differences between the two groups were statistically significant (P<0.001). After downregulation of NMIIA using RNA interference, the migratory and invasive abilities of the SGC‑7901 and MGC‑803 gastric cancer cell lines were observed using a wound‑healing assay and a Transwell assay, respectively. Knockdown of NMIIA significantly decreased the amount of wound closure as well as the number of cells which transgressed through the Matrigel (P<0.01). Finally, the levels of c‑Jun N‑terminal kinase (JNK), phosphorylated (p)‑JNK, c‑Jun and p‑c‑Jun were detected using western blot analysis in order to explore the association between NMIIA and the JNK signaling pathway. Knockdown of NMIIA decreased the levels of p‑JNK and p‑c‑Jun in the two gastric cancer cell lines (P<0.05). In conclusion, the present study indicated that knockdown of NMIIA inhibited the migration and invasion of gastric cancer cells, which may be, at least in part, mediated via the JNK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Downregulation of non-muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c-Jun N-terminal kinase signaling pathway

Liu

Zhang

et al. 2015

Molecular Medicine Reports

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KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells

Zhang

Liu

Wang

et al. 2013

J Cancer Res Clin Oncol

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α-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner

Zhao

Yang

et al. 2007

Cancer Letters

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Effect of vitamin E succinate on expression of TGF-β₁, c-Jun and JNK1 in human gastric cancer SGC-7901 cells

Abstract: Effect of vita min E succinate on expression of TGF-β1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells.

Cited by 20 publications

References 31 publications

Downregulation of non-muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c-Jun N-terminal kinase signaling pathway

Downregulation of non-muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c-Jun N-terminal kinase signaling pathway

KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells

α-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner

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Effect of vitamin E succinate on expression of TGF-β1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells

Abstract: Effect of vita min E succinate on expression of TGF-β1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells.

Cited by 20 publications

References 31 publications

Downregulation of non-muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c-Jun N-terminal kinase signaling pathway

Downregulation of non-muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c-Jun N-terminal kinase signaling pathway

KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells

α-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner

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Effect of vitamin E succinate on expression of TGF-β₁, c-Jun and JNK1 in human gastric cancer SGC-7901 cells