Effect of Vitamin E on Blood-Brain Barrier Permeability in Aged Rats with PTZ-Induced Convulsions

Yorulmaz, Hatice; Seker, Fatma Burcu; Öztaş, Baria

doi:10.1007/s11062-011-9168-6

Cited by 6 publications

(3 citation statements)

References 42 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies have shown the importance of Vitamin E in a dose-dependent manner as a protective factor for BBB permeability and have demonstrated that the dose dependence of this antioxidant in aged animals differs from that in younger organisms [84]. In this context, it is worth mentioning that previous studies have shown that the deficiency in vitamin E increases brain tissue oxidative stress and impairs the integrity of the blood-brain barrier, which may have relevance to the pathogenesis of amyotrophic lateral sclerosis and other neurological diseases [85].…”

Section: Oxidative Stressmentioning

confidence: 99%

Pathomechanisms of Blood-Brain Barrier Disruption in ALS

Kakaroubas

Brennan²,

Keon³

et al. 2019

Neuroscience Journal

View full text Add to dashboard Cite

The blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are responsible for controlling the microenvironment within neural tissues in humans. These barriers are fundamental to all neurological processes as they provide the extreme nutritional demands of neural tissue, remove wastes, and maintain immune privileged status. Being a semipermeable membrane, both the BBB and BSCB allow the diffusion of certain molecules, whilst restricting others. In amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, these barriers become hyperpermeable, allowing a wider variety of molecules to pass through leading to more severe and more rapidly progressing disease. The intention of this review is to discuss evidence that BBB hyperpermeability is potentially a disease driving feature in ALS and other neurodegenerative diseases. The various biochemical, physiological, and genomic factors that can influence BBB permeability in ALS and other neurodegenerative diseases are also discussed, in addition to novel therapeutic strategies centred upon the BBB.

show abstract

Section: Oxidative Stressmentioning

confidence: 99%

Pathomechanisms of Blood-Brain Barrier Disruption in ALS

Kakaroubas

Brennan²,

Keon³

et al. 2019

Neuroscience Journal

View full text Add to dashboard Cite

show abstract

“…Similarly, we get the same results for VIV. Moreover, both NAI and VIV cross the BBB [ 37 – 38 ], it means roles of NAI and VIV similar to the role of E20, GNT, THA, and HUP. Hopefully, NAI is a natural multiple inhibitors for multiple enzymes among A20, ACE, AChE, BACE1, BCHE, ChAT, CYLD, CYP1A1, GSK3β, IDE, MARK, MM-2, NEP, and PP2A.…”

Section: Resultsmentioning

confidence: 99%

Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network

Cao

Mao

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

This study begins with constructing the mini metabolic networks (MMNs) of beta amyloid (Aβ) and acetylcholine (ACh) which stimulate the Alzheimer’s Disease (AD). Then we generate the AD network by incorporating MMNs of Aβ and ACh, and other MMNs of stimuli of AD. The panel of proteins contains 49 enzymes/receptors on the AD network which have the 3D-structure in PDB. The panel of drugs is formed by 5 AD drugs and 5 AD nutraceutical drugs, and 20 non-AD drugs. All of these complexes formed by these 30 drugs and 49 proteins are transformed into dyadic arrays. Utilizing the prior knowledge learned from the drug panel, we propose a statistical classification (dry-lab). According to the wet-lab for the complex of amiloride and insulin degrading enzyme, and the complex of amiloride and neutral endopeptidase, we are confident that this dry-lab is reliable. As the consequences of the dry-lab, we discover many interesting implications. Especially, we show that possible causes of Tacrine, donepezil, galantamine and huperzine A cannot improve the level of ACh which is against to their original design purpose but they still prevent AD to be worse as Aβ deposition appeared. On the other hand, we recommend Miglitol and Atenolol as the safe and potent drugs to improve the level of ACh before Aβ deposition appearing. Moreover, some nutrients such as NADH and Vitamin E should be controlled because they may harm health if being used in wrong way and wrong time. Anyway, the insights shown in this study are valuable to be developed further.

show abstract

“…21 AT increases the permeability of blood brain barrier in streptozotocin induced convulsions in albino rats and spare the action on NPY release to attain the anticonvulsant effect of NPY. 22 AT, in any form, inhibits oxidation of low density lipoproteins and decreases phenomenon of thromboembolism and clot formation and hence decreases heart attacks. When it is given in combination with ascorbic acid (AA) and carotenoids provides safer and effective results.…”

Section: Discussionmentioning

confidence: 99%

Comparative effects of Alpha Tocopherol and Ascorbic Acid on Chronic Stress Induced Neuropeptide Y Derangements

Zainab

Munir²,

Ilahi³

et al. 2020

JIMDC

View full text Add to dashboard Cite

Background: Chronic stress decreases resilience of the body mainly due to hormonal imbalance. Neuropeptide Y-ergic system is abnormally regulated in chronic stress due to reduction-oxidation imbalance. The antioxidants such as alpha-tocopherol and ascorbic acid reduce this imbalance with positive effect on neuropeptide Y synthesis and release. This study was aimed to compare the protective effects of alpha-tocopherol and ascorbic acid on plasma neuropeptide Y levels in chronic stress.Material and Methods: This quasi-experimental study was done at Al-Nafees Medical College in collaboration with National Institute of Health Islamabad from January 2015 to January 2016 after taking institutional approval. Sixty male Sprague Dawley rats were obtained and divided equally into four groups; group I (control), group II (restraint stress group - chronic restraint stress six hours daily for 28 days), group III (restraint stress + alpha-tocopherol 50mg/kg body weight /day), and group IV (restraint stress + ascorbic acid 100mg /kg body weight /day). Cardiac puncture was done to obtain blood for biochemical analysis.Results: A significant decrease in plasma neuropeptide Y levels was seen in group II compared to group I, group III and group IV. However, alpha-tocopherol administration in group III showed positive effects on maintenance of plasma neuropeptide Y concentration with better p trend than that of ascorbic acid supplementation in group IV.Conclusions: Alpha-tocopherol supplementation has more potent effect than that of ascorbic acid on chronic restraint stress induced derangements in neuropeptide Y levels. It leads to less imbalance in neuropeptide Y levels during chronic stress.Key words: Ascorbic Acid, Alpha-Tocopherol, Chronic Stress, Neuropeptide Y

show abstract

Effect of Vitamin E on Blood-Brain Barrier Permeability in Aged Rats with PTZ-Induced Convulsions

Cited by 6 publications

References 42 publications

Pathomechanisms of Blood-Brain Barrier Disruption in ALS

Pathomechanisms of Blood-Brain Barrier Disruption in ALS

Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network

Comparative effects of Alpha Tocopherol and Ascorbic Acid on Chronic Stress Induced Neuropeptide Y Derangements

Contact Info

Product

Resources

About