Effect of vitamin E on sperm number and testis histopathology of sodium arsenite-treated rats

Momeni, Hamid Reza; Oryan, Shahrbanoo; Eskandari, Najmeh

doi:10.1016/s1642-431x(12)60084-9

Cited by 70 publications

(74 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This result demonstrated that Ve is of great importance to maintain normal morphology of sperm in fish species. In mice and rats, Ve has been reported to be able to reduce degenerative changes in testis and epididymis caused by spinal cord injury or toxicity of heavy metals such as mercury, lead, and arsenic (Rao and Sharma, 2001;Momeni et al, 2012;Wang et al, 2007;Fahima et al, 2013). These studies have suggested that the beneficial effects of Ve in preserving normal morphology of sperm and testis are mainly attributed to its antioxidative property.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary vitamin E on the sperm quality of turbot (Scophthalmus maximus)

Huang

Liang

et al. 2015

J. Ocean Univ. China

View full text Add to dashboard Cite

A 3-month feeding experiment was conducted in an in-door seawater system to investigate the effect of dietary vitamin E (Ve) on the sperm quality of turbot (Scophthalmus maximus). D-α-tocopherol acetate was supplemented to the basal (control) diet (65.14 mg kg -1 Ve) to obtain low and high levels of dietary Ve (244.60 mg kg -1 , LVe; 721.60 mg kg -1 , HVe). Compared with the control, sperm concentration was significantly increased in Ve-supplemented groups (LVe and HVe); while relative sperm volume and testis-somatic index were significantly increased in group HVe only. Sperm motility duration was significantly longer in group HVe than in the control, but no significant difference was observed in percent motility among groups. Sperm size, the uniformity of mitochondrial size, and the integrity of mitochondria cristae and plasma membrane were improved by dietary Ve, especially in HVe. The content of Ve in testis and liver as well as polyunsaturated fatty acids in sperm increased with dietary Ve. These results suggested that dietary Ve, especially at the high level (721.60 mg kg -1 ), significantly improved sperm concentration and motility duration and maintained normal sperm morphology of turbot.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of dietary vitamin E on the sperm quality of turbot (Scophthalmus maximus)

Huang

Liang

et al. 2015

J. Ocean Univ. China

View full text Add to dashboard Cite

show abstract

“…Injuries of Leydig cells, as a result of testicular oxidative stress, can alter testosterone levels and is a common feature in infertility (9). One possibility for the adverse effect of CCl 4 on sperm parameters may be due to the decrease in the level of FSH, LH, or testosterone (29). Serum levels of testosterone, LH, FSH, body weight, testis weight, and sperm parameters were restored to near control level by VE supplementation to CCl 4 -intoxicated rats.…”

Section: Sperm Parametersmentioning

confidence: 96%

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

et al. 2016

View full text Add to dashboard Cite

The increased generation of free radicals plays an important role in testicular damage. The present study aimed to investigate the adverse effects of carbon tetrachloride (CCl 4 ) on the reproductive system of male rats as well as to examine whether Vitamin E (VE) is able to ameliorate these effects. The rats were equally divided into three groups: control, CCl 4 -treated, and CCl 4 + VE-treated groups. After 4 weeks of treatment, the decrease in body and testes weights, sperm parameters, and the decrease in serum levels of testosterone, luteinizing hormone, and folliclestimulating hormone of CCl 4 -treated rats were ameliorated by VE treatment. The co-administration of VE with CCl 4 significantly decreased the level of lipid peroxidation production (malondialdehyde) and increased the activity of anti-oxidant enzymes (superoxide dismutase and catalase) when compared with the CCl 4 group. Moreover, VE prevented CCl 4 -induced severe testicular histopathological lesions and deformities in spermatogenesis. The results demonstrate that VE augments the anti-oxidants' defense mechanism against CCl 4 -induced reproductive toxicity suggesting a therapeutic role in free radical-mediated infertility.

show abstract

“…Likewise, height of seminiferous tubule's wall and reduced the mean diameter of seminiferous tubule's lumen were observed in treated animals. [58] Stallion 1 500 mg of α-tocopherol acetate for 60 d This dietary supplementation improved antioxidants status. The improvements in treatment vs control group increase in average path velocity [(121.9 ± 3.1) μm/sec in TG and (118.9 ± 4.3) μm/sec in CG), straightness (86.2% ± 2.4%) and (82.6% ± 3.9%) in TG and CG, respectively].…”

Section: Iumentioning

confidence: 99%

Effects of dietary vitamin E on male reproductive system

Zubair¹

2017

APJR

View full text Add to dashboard Cite

Effect of vitamin E on sperm number and testis histopathology of sodium arsenite-treated rats

Cited by 70 publications

References 37 publications

Effect of dietary vitamin E on the sperm quality of turbot (Scophthalmus maximus)

Effect of dietary vitamin E on the sperm quality of turbot (Scophthalmus maximus)

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

Effects of dietary vitamin E on male reproductive system

Contact Info

Product

Resources

About