Effect of vitamin E on lipid metabolism and atherosclerosis in ESRD patients

Application of constant-current coulometry for estimation of plasma total antioxidant capacity and its relationship with transition metal contents

“…The data obtained allow us to conclude that antioxidant therapy significantly increases TAC of plasma that is also confirmed in [42,43]. At first, it was shown that ximedon is effective as antioxidant that permits to enlarge the application area of this pharmaceutical.…”

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

“…After 2 years, the authors found that VECM significantly decreased serum oxLDL levels, MDA-LDL, and delayed the progress of atherosclerosis (assessed by aortic calcification index) in these patients. 176 A small, six-patient study by Pertosa Moreover, after the year of standard dialyzer therapy, all biomarkers returned to the increased baseline values. Based on the fact that ADMA has been repeatedly associated with death and CV events in HD patients, the authors suggested that VECM therapy might protect HD patients against these adverse events.…”

“…It might exert a timely and specific scavenging effect on ROS, retain endogenous serum antioxidants (especially vitamin E), and increase membrane biocompatibility. 176 The first study of the use of vitamin E-coated HD membranes (VECM) was performed 20 years ago. 177 The authors of the study proposed that VECM suppressed OS through several pathophysiological mechanisms: by increasing the serum levels of vitamin E, by directly suppressing lipid peroxidation, by protecting plasma thiols and GSH from oxidation and finally by interfering in the NO metabolism.…”

The effect of covalently bonded conjugated linoleic acid on the reduction of oxidative stress and blood coagulation for polysulfone hemodialyzer membrane

“…By bonding CLA, all of these negative reactions can be reduced to an acceptable level. New approaches such as hemolipodialysis, infusion of antioxidants by dialysate, and vitamin E-bonded membranes in hemodialysis have been introduced for antioxidation [10, [14][15][16][17][18]. These membranes can improve some antioxidant parameters and decrease the lipid peroxidation both in vitro and in vivo [48,49]; they can also decrease the accumulation of advanced glycation end-product (AGE) [50].…”

“…This dialyzer is based on a multilayer cellulose membrane, whose inner surface was coated with the liposoluble physiological antioxidant vitamin E [14]. Preliminary studies suggest that this membrane exhibited a beneficial effect on neutrophil activation, ROS production, and endothelial function compared to standard membranes [15][16][17][18].…”