Effect of vitamin E dietary intake on in vitro activation of aflatoxin B1

Aflatoxin B1 - Prevention of Its Genetic Damage by Means of Chemical Agents

“…These results clearly suggest the need for further research to understand the complex role of these vitamins in the mutagenesis and carcinogenesis of the aflatoxin. Such a complex response was also reported in rats fed on a variable diet of vitamin E (Cassand et al, 1993). Animals on a diet supplemented with a low amount of the vitamin (0.5 IU) increased P-450 IIB and IIIA enzyme activity, whereas a higher vitamin supplemented diet (5 IU) reduced these specific activities.…”

Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down’s syndrome

“…It is well known that some of the endogenous chromosomal lesions caused by oxidative damage can be reduced by free radical scavengers or protective agents (17). Several authors have demonstrated that vitamin E (DL-h-tocoferol) is a potent biological antioxidant, inhibiting lipid peroxidation and protecting DNA and chromosomes from oxidative damage (18)(19)(20)(21)(22)(23). Therefore, in order to evaluate if the high frequency of chromosomal lesions detected in G 2 in DS lymphocytes is related to an increment in oxidative damage, we studied the effect of vitamin E on the frequency of chromosomal aberrations (basal and in G 2 ) in control and DS lymphocytes.…”

“…It is well known that some of the endogenous chromosomal lesions caused by oxidative damage can be reduced by free radical scavengers or protective agents [17]. Several authors have demonstrated that vitamin E ( dl‐ α ‐tocoferol) is a potent biological antioxidant, inhibiting lipid peroxidation and protecting DNA and chromosomes from oxidative damage [18–23].…”