Effect of vitamin E and selenium on blood glutathione peroxidase activity and some immunological parameters in sheep

Milad, K.; Kováč, G.; Rácz, Olivér; Sipulová, A; Bajová, Viera

doi:10.17221/7843-vetmed

Cited by 33 publications

(30 citation statements)

References 21 publications

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“…Øvernes (1993) reported that adequate measures should be taken to ensure that animals receive on optimal supplementation of both Se and vitamin E. Selenium and Se plus vitamin E supplementation, when plasma Se concentration was within the reference value, appeared to contribute to a healthier udder status, but neither lamb weaning weights nor ewe productivity were enhanced by the treatment applied (Appeddu et al, 1994). Practically, Se supplementation enhances the level of Se and may indirectly improve animal performance (Sobiech & Kuleta, 2002), possibly by strengthening the immunity of the animals (Milad et al, 2001). Data obtained in this study indicated that two injections of Se and Se plus vitamin E given before mating significantly increased the incidence of oestrus response, and fecundity rates in ewes, daily weight gain of ewes 0 to 60 days postpartum, and lamb body weight at 60 days of age.…”

mentioning

confidence: 57%

<i>Short Communication</i> Effect of selenium-vitamin E injections of ewes on reproduction and growth of their lambs

Koyuncu¹,

Yerlikaya²

2007

SA J. An. Sci.

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The experiment was conducted on 90 Karacabey Merino ewes divided into three groups. The first group of ewes was treated with 5 mL 0.1% sodium selenate, the second with 5 mL 0.1% sodium selenate and 250 mg vitamin E, while the third one was a control group. The effect of intra-muscular injection of selenium (Se) and Se plus vitamin E on oestrus, fertility, prolificacy, number of lambs reared the weight of lambs at birth and the live weight gain for 60 days was investigated. The injections of Se plus vitamin E significantly increased the incidence of oestrus, fertility and prolificacy in ewes, lamb body weight at day 60 and daily weight gain of ewes for 60 days postpartum compared with the control group.

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mentioning

confidence: 57%

<i>Short Communication</i> Effect of selenium-vitamin E injections of ewes on reproduction and growth of their lambs

Koyuncu¹,

Yerlikaya²

2007

SA J. An. Sci.

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“…In our experiment, one hour after CCl 4 exposure several sheep became anorectic with muscular fasciculation, convulsions and with increased respiratory rate. Within three hours, however, all sheep recovered clinically (Milad et al 2000).…”

Section: Discussionmentioning

confidence: 91%

CCl4 Induced Genotoxicity and Protective Effect of Antioxidants after in vivo Administration to Sheep

Dianovský¹,

Šiviková²

2001

Acta Vet. Brno

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Dianovsk˘ J., K. ·iviková: CCl 4 Induced Genotoxicity and Protective Effect of Antioxidants After in vivo Administration to Sheep. Acta Vet. Brno 2001, 70: 467-472. Protective effect against carbon tetrachloride-induced genotoxicity was tested in sheep after antioxidative supplementation. Ten 3-4-year-old sheep were treated by carbon tetrachloride, orally. The total dose of 0.05 ml/kg b/w. was corresponding to the former recommended antihelminthic usage in the seventies. Five such sheep were pre-treated by injection of vitamin E (400 mg) and selenium (12 mg) subcutaneously 24 h prior to CCl 4 administration. Sister chromatid exchanges (as a DNA repair error detection technique) were used for genotoxic influences estimation. The technique was applied 16 days after CCl 4 administration in cultured peripheral lymphocytes. SCEs were significantly increased in both tested groups, i.e. with and without of antioxidative pre-treatment. However, the first group exhibited the significance of p < 0.05, contrary to the second untreated group in which the statistical significance reached p < 0.001 when using Student's t-test. This difference supports the protective genotoxic influence of the studied antioxidants in peripheral lymphocytes. In neither of the groups, a significant decrease in the proliferation index was recorded. Thus no cytotoxic effect on the investigated tissue has been proved. As our study showed, administration of a single concurrent treatment of vitamin E and selenium could reduce the genotoxic effect exhibited by the SCE frequencies in comparison to the non-protected individuals, remarkable.

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“…Similarly, Milad et al (2001) showed that selenium administration led to significant effects on the phagocytic activity index of leukocytes and neutrophils. Szabóová et al (2008) reported that Salvia officinalis extract application to rabbits resulted in higher phagocytic activity in their blood.…”

Section: Discussionmentioning

confidence: 97%

Effect of dietary Salvia officinalis essential oil and sodium selenite supplementation on antioxidative status and blood phagocytic activity in broiler chickens

et al. 2013

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Selected indicators of the antioxidant status and blood phagocytic activity were investigated in broiler chickens fed diets enriched with essential oil from Salvia officinalis and/or sodium selenite for 5 weeks. Twenty four one-day-old Ross 308 hybrid broilers were randomly divided into four groups according to dietary treatments. The control group was fed unsupplemented basal diet, whereas the feeds of three treatment groups were supplemented with essential oil (0.05%), sodium selenite (0.4 mg Se/kg dry matter) or their combination, respectively. The intake of diets containing essential oil alone or together with Se significantly elevated (P < 0.05) the total antioxidant status in plasma. The combination of essential oil and sodium selenite added to the basal diet resulted in significant reduction (P < 0.05) of superoxide dismutase activity in erythrocytes, increased activities of glutathione peroxidase in liver (P < 0.001) and duodenal mucosa (P < 0.05) compared to the control. Higher malondialdehyde concentrations in kidney tissues (P < 0.01) of chickens supplemented with sodium selenite were reduced by addition of essential oil to their diet. Blood phagocytic activity was significantly (P < 0.001) increased in both groups supplemented with selenium. The presented results demonstrate that Salvia officinalis essential oil and sodium selenite jointly added to diets had a more positive effect on the antioxidant status of broilers than when both additives were administered separately.

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Effect of vitamin E and selenium on blood glutathione peroxidase activity and some immunological parameters in sheep

Cited by 33 publications

References 21 publications

<i>Short Communication</i> Effect of selenium-vitamin E injections of ewes on reproduction and growth of their lambs

<i>Short Communication</i> Effect of selenium-vitamin E injections of ewes on reproduction and growth of their lambs

CCl4 Induced Genotoxicity and Protective Effect of Antioxidants after in vivo Administration to Sheep

Effect of dietary Salvia officinalis essential oil and sodium selenite supplementation on antioxidative status and blood phagocytic activity in broiler chickens

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