Effect of vitamin D supplementation of low birth weight term Indian infants from birth on cytokine production at 6 months

Kumar, Geeta Trilok; Arora, Hitesh; Rajput, Mohammad Muntafa; Chellani, Harish; Singh, Sanjiv; Raynes, John G.; Arya, Sugandha; Aggarwal, Shweta; Srivastava, Nidhi; Sachdev, H. P. S.; Filteau, Suzanne

doi:10.1038/ejcn.2012.33

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Studies have shown that high-dose vitamin D supplementation may have a negative impact on the linear growth of children, by comparing the development of infants with a daily intake of more than 1500 UI of vitamin D and 300–600 UI, and found that the growth rate of infants in the high-dose group was reduced [ 21 ]. Previous studies pointed out that oral vitamins generate slight influence on children's linear growth, growth retardation, hypercalcemia, etc., only yield a light increase in the linear growth index of low-birth-weight infants.…”

Section: Discussionmentioning

confidence: 99%

Effects of Routine Health Care Combined with Oral Vitamin D on Linear Growth in 5-Year-Old Children

Zeng

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim is to evaluate the effects of routine health care combined with oral vitamin D on linear growth in 5-year-old children. Materials and Methods. The 5-year-old children who received routine health care in Shiyan Maternal and Child Health Care Hospital from January 2019 to January 2021 were retrospectively analyzed. They were divided into the supplement group and the non-supplement group according to whether or not they received oral vitamin D, and reasons for not taking oral vitamin D and its influence on children’s linear growth were analyzed. Results. A total of 368 children were enrolled, including 228 children in the supplement group, accounting for 61.96%. The analysis of the influencing factors of vitamin D supplementation showed that the proportion of children with well-educated parents and living in cities and towns was higher (all P < 0.05 ). Comparing the general situation of children in the two groups, it was found that the height, weight, and head circumference of children in the supplement group were notably higher than those in the non-supplement group (all P < 0.05 ). At age 4 and 5, the height of the supplement group was significantly higher than that of the non-supplement group (all P < 0.001 ). Linear analysis showed that the relationship between height and age in the supplement group was Y (height, cm) = 10.07 × X (age, years) + 61.18, while that in the non-supplement group was Y (height, cm) = 8.296 × X (age, years) + 62.81, with significant difference (all P < 0.05 ). Serum 25-hydroxyvitamin D concentration in the supplement group was significantly higher than that in the non-supplement group, and the proportion of children ≥75 nmol/L was evidently higher than that in the supplement group (all P < 0.05 ). In addition, the incidence of vitamin D-related hypercalcemia in the supplement group was significantly higher than that in the non-supplement group (all P < 0.05 ). Conclusion. There are still more children without vitamin D supplement, which is closely related to their parents’ education background and place of residence. Additionally, vitamin D supplementation can promote growth and improve 25-hydroxyvitamin D levels in children, but with the risk of related complications.

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Section: Discussionmentioning

confidence: 99%

Effects of Routine Health Care Combined with Oral Vitamin D on Linear Growth in 5-Year-Old Children

Zeng

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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“…However, these associations were not found in symptomatic patients 52. In a randomized controlled trial of vitamin D supplements (1,400 IU/week) in infants, there were no differences in plasma levels of CRP or inflammatory cytokines between the treatment group and the control group 53. The exact effects and mechanisms of vitamin D in infectious diseases therefore require further study.…”

Section: Vitamin D and Inflammatory Diseasesmentioning

confidence: 90%

Vitamin D and inflammatory diseases

Yin¹,

Agrawal²

2014

JIR

231

119

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Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitamin D status with increased risk and unfavorable outcome of acute infections. Vitamin D supplementation bolsters clinical responses to acute infection. Moreover, chronic inflammatory diseases, such as atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and others, tend to have lower vitamin D status, which may play a pleiotropic role in the pathogenesis of the diseases. In this article, we review recent epidemiological and interventional studies of vitamin D in various inflammatory diseases. The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are also discussed.

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“…From a total of 1652 texts screened for relevance, 35 articles fulfilled the inclusion criteria. Seven studies (26)(27)(28)(29)(30)(31)(32) were secondary or follow-up analyses of trials originally described in another article identified by the search strategy (Supplemental Table 2). Of the 28 distinct trials, 5 (33)(34)(35)(36)(37) were eligible for both narrative review and meta-analysis, and 23 were summarized in narrative format only (Figure 1).…”

Section: Literature Search and Trial Characteristicsmentioning

confidence: 99%

Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation

O'Callaghan

Taghivand

Zuchniak

et al. 2020

Advances in Nutrition

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Daily oral vitamin D supplementation (400 IU) is recommended for breastfeeding infants (≤1 y). Recent studies have examined alternative approaches to preventing vitamin D deficiency in this population. This systematic review and meta-analysis aimed to estimate the effects of maternal postpartum (M-PP) or infant intermittent (I-INT) vitamin D supplementation on infant 25-hydroxyvitamin D [25(OH)D] concentrations in comparison to routine direct infant daily (I-D) oral supplementation (400 IU). MEDLINE, MEDLINE In-Process, Embase, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched up to December 2018. Inclusion criteria consisted of published, peer-reviewed, vitamin D intervention trials involving lactating women and/or exclusively or partially breastfed term infants. Two reviewers independently extracted study characteristics (e.g., sample size, intervention dose, and duration and mode of administration) and related biochemical and clinical outcomes. Of 28 included trials, 5 randomized controlled trials were incorporated in meta-analyses examining infant 25(OH)D. Overall, M-PP supplementation resulted in modestly lower infant 25(OH)D compared with I-D supplementation (weighted mean difference = −8.1 nmol/L; 95% CI: −15.4, −0.9; I2 = 45%; P = 0.14; 3 trials), but the 2 most recent trials found M-PP to achieve similar infant 25(OH)D as I-D. Comparison of I-INT with I-D was confined to 2 trials with contradictory findings, and it was considered inappropriate for pooled analysis. Meta-analysis was therefore limited by a small number of eligible trials with variable quality of analytically derived 25(OH)D data and inconsistent reporting of safety outcomes, including effects on calcium homeostasis. Considering all 28 included trials, this systematic review highlights M-PP and I-INT regimens as plausible substitutes for routine daily infant vitamin D supplementation, but evidence remains too weak to support a policy update. Dose-ranging, adequately powered trials are required to establish the efficacy, safety, and feasibility of alternative strategies to prevent vitamin D deficiency in breastfeeding infants. This review was registered with PROSPERO as CRD42017069905.

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Effect of vitamin D supplementation of low birth weight term Indian infants from birth on cytokine production at 6 months

Abstract: Vitamin D supplementation did not affect plasma CRP or whole blood cytokine production of vitamin D-deficient low birth weight infants. This is consistent with the lack of effect of vitamin D on mortality and severe morbidity among infants in the DIVIDS trial.

Cited by 8 publications

References 27 publications

Effects of Routine Health Care Combined with Oral Vitamin D on Linear Growth in 5-Year-Old Children

Effects of Routine Health Care Combined with Oral Vitamin D on Linear Growth in 5-Year-Old Children

Vitamin D and inflammatory diseases

Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation

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