Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blinded Placebo-Controlled Trial

Abdellah, Ahmed H.; Ali, Ahmed M.; Khodry, Mustafa M.; El-Rasheedy, Mahmoud I.; Abbas, Ahmed M.

doi:10.4236/ojog.2018.814155

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…While no statistically significant differences were noted in implantation rates, there was an interesting trend suggesting a reduction in the abortion rate for the study group. This is a surprising result compared to other studies in which VD supplementation did not yield significant benefits in terms of embryo quality [ 32 , 45 ].…”

Section: Discussioncontrasting

confidence: 74%

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Baldini,

Russo,

Proietti

et al. 2024

Arch Gynecol Obstet

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Purpose The study aims to demonstrate the effects of Vitamin D (VD) supplementation, prior to oocyte pick-up within IVF protocols, in women with diverse VD status at the enrollment. Methods A total of 204 women eligible for intra-cytoplasmatic sperm injection (ICSI) cycles were included in the study and two homogeneous groups were selected from the database. Both group of patients with normal VD baseline level (> 40 ng/ml) and patients with low VD baseline level (< 20 ng/ml) were divided into control group and treatment group. The control group followed the standard procedure. The treatment group was supplemented with vitamin D3 as cholecalciferol in combination with Myo-Inositol, folic acid, and melatonin 3 months before standard procedure, once a day in the evening. Results VD levels significantly increased in the study group of low baseline VD, both in serum and in the follicular fluid compared to controls. The treatment induced a significant improvement of the embryo quality in both group of patients considered. Conclusion Supplementation of VD in patients undergoing ICSI procedures significantly improved the number of top-quality embryos compared with the control group, either starting from VD normal baseline values or starting from low values. Trial registration number 07/2018.

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Section: Discussioncontrasting

confidence: 74%

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Baldini,

Russo,

Proietti

et al. 2024

Arch Gynecol Obstet

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“…However, all these studies analyzed and discussed many reproductive outcomes with quite different conclusions and did not provide results on the effect of vitamin D on OHSS risk. The analysis of the different RCTs available [50,[107][108][109][110][111][112][113] showed that only one RCT included as a secondary endpoint the adverse events, including high OHSS risk [50]. In particular, in a double-blind placebo-controlled trial [50], a total of 630 infertile IVF patients with low vitamin D levels (less than 30 ng/mL) were randomized to receive 600,000 IU vitamin D pretreatment (from 2 to 12 weeks before IVF) or a placebo.…”

Section: Vitamin Dmentioning

confidence: 99%

Beyond the Umbrella: A Systematic Review of the Interventions for the Prevention of and Reduction in the Incidence and Severity of Ovarian Hyperstimulation Syndrome in Patients Who Undergo In Vitro Fertilization Treatments

Palomba,

Costanzi,

Nelson

et al. 2023

IJMS

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Ovarian hyperstimulation syndrome (OHSS) is the main severe complication of ovarian stimulation for in vitro fertilization (IVF) cycles. The aim of the current study was to identify the interventions for the prevention of and reduction in the incidence and severity of OHSS in patients who undergo IVF not included in systematic reviews with meta-analyses of randomized controlled trials (RCTs) and assess and grade their efficacy and evidence base. The best available evidence for each specific intervention was identified, analyzed in terms of safety/efficacy ratio and risk of bias, and graded using the Oxford Centre for Evidence-Based Medicine (CEBM) hierarchy of evidence. A total of 15 interventions to prevent OHSS were included in the final analysis. In the IVF population not at a high risk for OHSS, follitropin delta for ovarian stimulation may reduce the incidence of early OHSS and/or preventive interventions for early OHSS. In high-risk patients, inositol pretreatment, ovulation triggering with low doses of urinary hCG, and the luteal phase administration of a GnRH antagonist may reduce OHSS risk. In conclusion, even if not supported by systematic reviews with homogeneity of the RCTs, several treatments/strategies to reduce the incidence and severity of OHSS have been shown to be promising.

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Vitamin D and women’s reproductive health

Khabarov¹,

Khadartseva²,

Волков³

2020

Ross. vestn. akush.-ginekol.

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Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blinded Placebo-Controlled Trial

Abstract: OBJECTIVE: To assess the effect of vitamin D supplementation on enhancement of embryos implantation rates in intracytoplasmic sperm injection procedures. STUDY DESIGN: A randomized double-blinded controlled trial.

Cited by 4 publications

References 19 publications

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients’ basal vitamin D status

Beyond the Umbrella: A Systematic Review of the Interventions for the Prevention of and Reduction in the Incidence and Severity of Ovarian Hyperstimulation Syndrome in Patients Who Undergo In Vitro Fertilization Treatments

Vitamin D and women’s reproductive health

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