Effect of vitamin D supplementation and magnesium sulfate therapy in pre-eclampsia

Bhaskar, Neeru; Kaur, Harpreet; Ishaq, Sheikh; Mahajan, Ruhi; Najeeb, Qazi

doi:10.4103/2230-8598.133134

Cited by 1 publication

(2 citation statements)

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“…[1,2]It accounts for about 25% of maternal mortality and is a major cause of perinatal and maternal morbidity and mortality. [3][4][5] A previous Nigerian study by Obiechina et al,[6]has put maternal mortality from preeclampsia/eclampsia at 27%. In another Nigerian study on hypertensive disorders of pregnancy, with severe preeclampsia as the leading cause, the reported stillbirth rate was 17.4% and the perinatal mortality rate was 20.9%.…”

Section: Introductionmentioning

confidence: 99%

“…[12] This may be due to high amount of melanin in the skin of black women which reduces the amount of sunlight that get to the skin for production of vitamin D. [13]Magnesium sulphate which is used in the treatment of preeclampsia is known to increase the levels of parathyroid hormone which in turn promotes the conversion of 25-hydroxycalciferol to 1,25dihydroxycalciferol and also increases the production of 1,25-dihydroxycalciferol from the placenta. [3] Seasonal patterns in preeclampsia also suggest a role for vitamin D and sunlight. The incidence of preeclampsia is higher during winter months, when sunlight-dependent 25hydroxyvitamin D production is lower.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum hypovitaminosis D and preeclampsia: A nested case-control study

Okoro¹,

Udigwe²,

Eleje³

et al. 2023

Magna Sci. Adv. Res. Rev.

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Background: Preeclampsia is a major complication of pregnancy and a major cause of perinatal and maternal morbidity and mortality. Vitamin D deficiency has been implicated in the aetiology and pathophysiology of preeclampsia. However, there is no uniformity in the findings of previous studies on the association between vitamin D and preeclampsia. Aims and Objectives: The study is aimed at determining the association between preeclampsia and maternal vitamin D deficiency. Materials and Methods: This nested case-control study was conducted among 158 pregnant women (78 preeclamptic women and 80 controls) with singleton pregnancies. Case participants were women with preeclampsia. The controls were matched pregnant women without preeclampsia. Their serum vitamin D levels were determined. Statistics: Continuous data was analysed using T-test. The statistical significance was inferred at p- value ≤0.05. Results: The prevalence of hypovitaminosis D in our study was 7.0% overall. The proportion of women with hypovitaminosis D was not significantly different between preeclampsia group and control group (7.7% vs 6.3% respectively; p=0.76). The mean serum concentration of vitamin D in the preeclamptic group was lower than that in the control group, however, the difference was not statistically significant (118.8±17.4nmol/L vs 129.0±19.7nmol/L, p=0.17). There was a weak association between gestational age and the level of serum vitamin D in both groups (r= 0.062 and r= -0.13 respectively). Conclusions: Hypovitaminosis D is not significantly associated with preeclampsia when compared with control. However, there was a weak association between gestational age and the level of serum vitamin D in both groups.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%