Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double‐blind randomized clinical trial

Sheikh, Vida; Mozaianimonfared, Azadeh; Gharakhani, Mohsen; Poorolajal, Jalal; D., Ph.

doi:10.1111/jch.13926

Cited by 19 publications

(17 citation statements)

References 35 publications

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“…For this reason, increasing disease duration may decrease in vitamin D due to aging and increase the severity of TOD due to the rate of atherosclerosis. On the other hand, considering the effect of Vitamin D on RAAS, the effectiveness of anti-hypertensive treatments may be affected (37,38). Therefore, in hypertensive patients with VDD, Vitamin D supplementation can reduce the probability of TOD, slow down or prevent the atherosclerotic process, regardless of disease duration or anti-hypertensive drugs.…”

Section: Discussionmentioning

confidence: 99%

The relationship between vitamin D deficiency and hypertensive organ damage

Şabanoğlu

İnanç

2022

Journal of Health Sciences and Medicine

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Aim: In this study, we aimed to examine the relationship between vitamin D level and target organ damage (TOD) in primary hypertension patients by eliminating the effects of hypertension duration and antihypertensive treatments. Material and Method: The study included 144 patients with primary hypertension. Vitamin D levels were classified as sufficiency (VDS), deficiency (VDD), and severe deficiency (VDSD). In case of more than one TOD indicator (microalbuminuria or proteinuria, left ventricular mass index and carotid intima-media thickness), it was considered as multi organ involvement (OI). In the multiple regression model, besides the traditional risk factors, the effects of hypertension duration and anti-hypertensive treatments were adjusted. Results: The rates of VDS and VDD were lower in TOD (+) compared to TOD (-) (14.1% vs 51.5%, 32.1% vs 42.4%; p

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Section: Discussionmentioning

confidence: 99%

The relationship between vitamin D deficiency and hypertensive organ damage

Şabanoğlu

İnanç

2022

Journal of Health Sciences and Medicine

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“…It demonstrated that vitamin D supplementation was significantly effective in reducing SBP 1 and 2 months after supplementation, and it was effective on DBP only 1 month after supplementation. 52 In a review of seven studies by Zittermann, 53 four found lower BP in healthy individuals treated with vitamin D3 supplementation and three found no effect.…”

Section: Vitamin D Deficiency and Hypertension And Left Ventricular H...mentioning

confidence: 99%

Association between vitamin D and cardiovascular health: Myth or Fact? A narrative review of the evidence

Ahmadieh

Arabi

2023

Womens Health (Lond Engl)

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Vitamin D deficiency is prevalent worldwide. Since the discovery of the expression of vitamin D receptor in ventricular cardiomyocytes, fibroblasts, and blood vessels, there has been a growing body of literature assessing the link between vitamin D status and cardiovascular health from one side, and the effect of vitamin D supplementation on prevention of cardiovascular diseases from the other side. In this review, we summarized studies highlighting the role of vitamin D on cardiovascular health, namely atherosclerosis, hypertension, heart failure, and metabolic syndrome, a recognized significant risk factor for cardiovascular diseases. Studies showed discrepancies between findings from cross-sectional and longitudinal cohorts and those from interventional trials, but also between one outcome and another. Cross-sectional studies found a strong association between low 25 hydroxyvitamin D (25(OH)D3) and acute coronary syndrome, and heart failure. These findings encouraged the promotion for vitamin D supplementation as a preventive measure for cardiovascular diseases in the elderly, namely in women. This fact, however, turned out into a myth with the results of large interventional trials that did not show any benefit from vitamin D supplementation in reducing ischemic events, heart failure or its outcomes, or hypertension. Although some clinical studies showed beneficial effect of vitamin D supplementation on insulin sensitivity and metabolic syndrome, this effect was not consistent across all studies.

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“…These findings are consistent with the results of two earlier RCTs that also found that daily administration of a VD analog could reduce BP in hypertensive patients in which 25[OH]D levels were not known [ 45 , 46 ]. Another two RCTs demonstrated that weekly doses of VD resulted in effective reductions in BP in hypertensive patients with VDD [ 47 , 48 ]. Despite the comparatively small sample sizes in these trials, these outcomes consistently demonstrate that daily or weekly administration of appropriate doses of VD or its analogs can significantly reduce BP in VD-deficient hypertensive populations.…”

Section: Vd Supplementation Reduces Bp In Hypertensive Patients With Vddmentioning

confidence: 99%

Is Vitamin D Supplementation an Effective Treatment for Hypertension?

2022

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Purpose of the Review Results from epidemiological studies suggest that vitamin D (VD) deficiency (VDD) may be a cause of hypertension (HTN). However, the results of randomized clinical trials (RCTs) designed to address the impact of VD supplementation on reducing blood pressure (BP) remain equivocal. To determine whether VD might serve as a beneficial treatment option for a specific subset of hypertensive patients, we performed a stratified analysis of RCT data and addressed problems associated with some methodological issues. Recent Findings HTN is caused by multiple factors. VDD may be one of the factors contributing to the development of this disorder. There are more than 70 RCTs that examined the impact of VD supplementation on BP. These RCTs can be classified into four groups based on their respective study populations, including participants who are (1) VD-sufficient and normotensive, (2) VD-deficient and normotensive, (3) VD-sufficient and hypertensive, and (4) VD-deficient and hypertensive. Summary Our evaluation of these studies demonstrates that VD supplementation is ineffective when used to reduce BP in VD-sufficient normotensive subjects. VD supplementation for five years or more may reduce the risk of developing HTN specifically among those with VDD. Interestingly, findings from 12 RCTs indicate that daily or weekly supplementation, as opposed to large bolus dosing, results in the reduction of BP in VD-deficient hypertensive patients. Our ongoing research focused on elucidating the mechanisms of VDD-induced HTN will ultimately provide evidence to support the development of etiology-specific prevention and treatment strategies focused on HTN in the VD-deficient population.

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Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double‐blind randomized clinical trial

Cited by 19 publications

References 35 publications

The relationship between vitamin D deficiency and hypertensive organ damage

The relationship between vitamin D deficiency and hypertensive organ damage

Association between vitamin D and cardiovascular health: Myth or Fact? A narrative review of the evidence

Is Vitamin D Supplementation an Effective Treatment for Hypertension?

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