Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta‐Analysis

Beveridge, Louise A.; Khan, Faisel; Struthers, Allan D.; Armitage, Jane; Barchetta, Ilaria; Bressendorff, Iain; Cavallo, Maria Gisella; Clarke, Robert; Dalan, Rinkoo; Dreyer, Gavin; Gepner, Adam D.; Forouhi, Nita G.; Harris, Ryan A.; Hitman, G. A.; Larsen, Thomas; Khadgawat, Rajesh; Marckmann, Peter; Mose, Frank Holden; Pilz, Stefan; Scholze, Alexandra; Shargorodsky, Marina; Sokol, Seth I.; Stricker, Hans; Zoccali, Carmine; Witham, Miles D.

doi:10.1161/jaha.117.008273

Cited by 65 publications

(53 citation statements)

References 63 publications

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“…In fact, vitD supplementation is used as a treatment in several pathologies regardless of baseline serum levels. This mistaken approach rendered dissimilar results; thus, vitD supplements failed to prevent cancer or to reduce cardiovascular events [53][54][55]. However, in patients with baseline vitD levels less than 25 nmol/L (10 ng/mL), supplements were beneficial in respiratory diseases, such as reducing asthma [16] and chronic obstructive pulmonary disease [17] exacerbations.…”

Section: Discussionmentioning

confidence: 99%

Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension

Callejo

Mondéjar-Parreño

Esquivel-Ruiz

et al. 2020

JCM

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Introduction: Epidemiological studies suggest a relationship between vitamin D deficiency and cardiovascular and respiratory diseases. However, whether total, bioavailable, and/or free vitamin D levels have a prognostic role in pulmonary arterial hypertension (PAH) is unknown. We aimed to determine total, bioavailable, and free 25-hydroxy-vitamin D (25(OH)vitD) plasma levels and their prognostic value in PAH patients. Methods: In total, 67 samples of plasma from Spanish patients with idiopathic, heritable, or drug-induced PAH were obtained from the Spanish PH Biobank and compared to a cohort of 100 healthy subjects. Clinical parameters were obtained from the Spanish Registry of PAH (REHAP). Results: Seventy percent of PAH patients had severe vitamin D deficiency (total 25(OH)vitD < 10 ng/mL) and secondary hyperparathyroidism. PAH patients with total 25(OH)vitD plasma above the median of this cohort (7.17 ng/mL) had better functional class and higher 6-min walking distance and TAPSE (tricuspid annular plane systolic excursion). The main outcome measure of survival was significantly increased in these patients (age-adjusted hazard ratio: 5.40 (95% confidence interval: 2.88 to 10.12)). Vitamin D-binding protein (DBP) and albumin plasma levels were downregulated in PAH. Bioavailable 25(OH)vitD was decreased in PAH patients compared to the control cohort. Lower levels of bioavailable 25(OH)vitD (<0.91 ng/mL) were associated with more advanced functional class, lower exercise capacity, and higher risk of mortality. Free 25(OH)vitD did not change in PAH; however, lower free 25(OH)vitD (<1.53 pg/mL) values were also associated with high risk of mortality. Conclusions: Vitamin D deficiency is highly prevalent in PAH, and low levels of total 25(OH)vitD were associated with poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension

Callejo

Mondéjar-Parreño

Esquivel-Ruiz

et al. 2020

JCM

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“…Further, for vitamin C supplementation, there is currently no evidence that this has any clinical meaningful effect on vascular function [77]. Finally, there is no evidence that supplements of vitamin D or E have any positive effect on the vasculature [78,79].…”

Section: Supplementation Of Other Vitaminsmentioning

confidence: 99%

Pharmacological and Nutritional Modulation of Vascular Calcification

et al. 2019

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Vascular calcification is an independent predictor of cardiovascular disease, and therefore, inhibition or regression of this processes is of clinical importance. The standard care regarding prevention and treatment of cardiovascular disease at this moment mainly depends on drug therapy. In animal and preclinical studies, various forms of cardiovascular drug therapy seem to have a positive effect on vascular calcification. In particular, calcium channel blockers and inhibitors of the renin–angiotensin–aldosteron system slowed down arterial calcification in experimental animals. In humans, the results of trials with these drugs are far less pronounced and often contradictory. There is limited evidence that the development of new atherosclerotic lesions may be retarded in patients with coronary artery disease, but existing lesions can hardly be influenced. Although statin therapy has a proven role in the prevention and treatment of cardiovascular morbidity and mortality, it is associated with both regression and acceleration of the vascular calcification process. Recently, nutritional supplements have been recognized as a potential tool to reduce calcification. This is particularly true for vitamin K, which acts as an inhibitor of vascular calcification. In addition to vitamin K, other dietary supplements may also modulate vascular function. In this narrative review, we discuss the current state of knowledge regarding the pharmacological and nutritional possibilities to prevent the development and progression of vascular calcification.

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“…In addition, the VD may play a protective role during cerebral ischemia, although it associates with a wide range of illness states and physiological derangements [13] that can lead to worsen outcomes after stroke [10,14,15].…”

Section: Severity and Disability Definitionmentioning

confidence: 99%

The Role of Mineral Serum Level in Risk Factor of Stroke. Babol, North of Iran

Ahangar¹,

Khafri²,

Saadat³

et al. 2019

J Neurol Exp Neurosci

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Background: The relationship between stroke and mineral status is inconsistent. With regard to doubt in the role of mineral, this study was conducted. Material and Method: This cross-sectional study on 216 stroke patients who referred to the Ayatollah Rouhani Hospital of Babol over one-year period were conducted. Serum level of calcium (Ca), magnesium (Mg), Vitamin D (VD) were measured. Chi-square or Fisher exact test in spss 23 used. Result: Difference of hemorrhagic subtype was statistically significant in hypertensive patients (20(87%) ICH vs. 1(12.5%) SAH, p = 0.001). In thrombotic patients, 98 cases (89%) low VD vs. 12 cases (10.9%) normal VD, (p = 0.001) were seen. Also, low VD was more seen significantly in DM patients 72(90%) in compare to non-DM patients 96(72.7%), (p = 0.003). Of 120 cases (56.3%) who had HTN, 103 cases (85.8%) low VD vs. 17 cases (14.2%) normal VD, (p = 0.01), 68 cases (57.1%) hypo calcemic vs. 45 cases (37.8%) normal Ca serum level, (p < 0.0001) and 57 cases (49.1%) hypomagnesemia vs. 59 cases (50.9%) normal magnesium (p = 0.04) were seen. Difference in sex was statistically significant with hypomagnesemia (49 cases (53.8%) male vs. 38 cases (33.9%) female, p = 0.007). Hypomagnesemia were seen in 87 cases (40.8%) that 49 cases of this were hypo-calcemic (56.3%), (p = 0.03). Differences in magnesium with VD was statistically significant (170 cases (79.4%) low VD vs. 44 cases (20.6%) normal, p = 0.007). Conclusion: Low VD in thrombotic and diabetic patients, low Ca and VD in hypertensive patients and hypocalcemia were more seen in hypermagnesemic patients. Preventive policies such as screening of mineral serum level are suggested.

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Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta‐Analysis

Cited by 65 publications

References 63 publications

Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension

Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension

Pharmacological and Nutritional Modulation of Vascular Calcification

The Role of Mineral Serum Level in Risk Factor of Stroke. Babol, North of Iran

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