Effect of Vitamin D Supplementation on Blood Pressure

Beveridge, Louise A.; Struthers, Allan D.; Khan, Faisel; Jorde, Rolf; Scragg, Robert; Macdonald, Helen; Alvarez, Jessica A.; Boxer, Rebecca S.; Dalbeni, Andrea; Gepner, Adam D.; Isbel, Nicole M.; Larsen, Thomas; Nagpal, Jitender; Petchey, William; Stricker, Hans; Strobel, Franziska; Tangpricha, Vin; Toxqui, Laura; Vaquero, M. Pilar; Wamberg, Louise; Zittermann, Armin; Witham, Miles D.

doi:10.1001/jamainternmed.2015.0237

Cited by 273 publications

(117 citation statements)

References 74 publications

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“…Organ damage is more closely associated with central BP (cBP) than brachial BP [81] and, whilst individuals could have similar brachial systolic BP levels, central systolic BP may significantly differ [82]. Only 1 study has shown VitD supplementation to be effective in decreasing cBP (Table 1) [83], whereas others have shown no improvement in older individuals with osteoarthritis [77] or among postmenopausal women [61,62].…”

Section: Summary Of Rct Data On the Effect Of Vitd Supplementation Onmentioning

confidence: 99%

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Veloudi

Jones

Sharman³

2016

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There is a plausible physiological theory, supported by many observational studies, that vitamin D supplementation should be effective for improving cardiovascular end points, such as blood pressure (BP), large artery stiffness, atherosclerosis, endothelial function and clinical events. However, results from randomised controlled trials (RCTs) have been inconsistent. In this review, we evaluated the evidence regarding the effectiveness of vitamin D supplementation for cardiovascular surrogate and hard clinical end points. RCTs were assessed in terms of sample size, duration of supplementation, baseline vitamin D level inclusion criteria (i.e., absence of vitamin D deficiency), dosage of vitamin D and population under investigation. Forty-five RCTs were identified. Eight RCTs with BP and 6 RCTs with large artery stiffness as the end points were found to comply with guidelines for the optimal design of clinical trials evaluating nutrient effects. Only 2 of the RCTs with an optimal design were effective in decreasing BP with vitamin D supplementation, although these were of moderate sample size (<150) and very short duration (8 weeks for both), whilst no RCT was effective in reducing large artery stiffness. Similar results were observed for atherosclerotic and endothelial function markers as end points. Only 1 RCT reported cardiovascular events as an end point and found neither increased nor decreased incident cardiovascular events over 7 years of follow-up. In conclusion, results from published RCTs indicate that vitamin D supplementation is ineffective in improving cardiovascular health among various patient populations, including in the presence or absence of vitamin D deficiency.

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Section: Summary Of Rct Data On the Effect Of Vitd Supplementation Onmentioning

confidence: 99%

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Veloudi

Jones

Sharman³

2016

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“…This year alone, quantitative meta-analyses of arterial stiffness outcomes have been published by Upala et al [6] and Rodríguez et al [7] summarising 7 and 18 RCTs, respectively. A recent quantitative meta-analysis on peripheral blood pressure outcomes identified 46 independent vitamin D supplementation trials [5]. These quantitative studies, although not included in the review by Veloudi et al [4], support the same conclusion which Veloudi et al [4] make from a qualitative review of RCTs, namely that vitamin D supplementation has no effect on arterial stiffness or blood pressure.…”

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confidence: 85%

“…In so doing, the article highlights that very few of these studies show a beneficial effect of vitamin D supplementation. The graphical presentation of the data also allows a visual representation of the previous finding, demonstrated statistically, that there is no relationship between an increased dose of vitamin D supplement and beneficial cardiovascular effect [5]. …”

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confidence: 99%

Cardiovascular Effects of Long-Term Vitamin D Supplementation: Summarised by Many but Studied by Few

Butlin

Avolio

2016

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“…Мета-анализы указывают на отсутствие влияния приема витамина D на артериальное давление [50], ар-териальную жесткость [51,52] и эндотелиальную функ-цию [53]. На потенциальную пользу в отношении сердеч-но-сосудистой системы от приема высоких доз витамина D указывают данные ряда исследований; так, данные Zaleski и соавт.…”

Section: витамин D и сердечно-сосудистые заболеванияunclassified

Non-classical effects of vitamin D

et al. 2018

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Остеопороз и остеопатии / Osteoporosis and Bone Diseases | 90 REVIEW ВВЕДЕНИЕФактор, недостаточность которого приводит к раз-витию рахита, был открыт и назван витамином D око-ло 100 лет назад; на протяжении прошедшего с тех пор времени было получено множество данных, свидетель-ствующих о том, что это вещество не только необхо-димо для нормального развития и функционирования костной ткани, но и является гормоном, опосредующим разнообразные эффекты в других тканях организма. В связи с этим значительный интерес представляет подробное изучение физиологической роли витами-на D в организме, его значения в функционировании тканей и органов, а также вклада, который вносит из-менение его метаболизма в развитие хронических за-болеваний, течение и исход беременности. Достижение специфических для отдельных тканей результатов при коррекции уровня витамина D ставит вопрос о возмож-ной целесообразности проведения профилактических и терапевтических мероприятий при соответствующих состояниях. ОСОБЕННОСТИ МЕТАБОЛИЗМА ВИТАМИНА D, РЕЦЕПТОРА ВИТАМИНА D, ВИТАМИН D-СВЯЗЫВАЮЩЕГО БЕЛКАВитамин D3 (колекальциферол) образуется в коже из 7-дегидрохолестерола в два этапа. На первом этапе под действием УФ-излучения (280-320 нм) образуется пре-витамин D3, который изомеризуется в D3 в резуль-тате термочувствительного, но некаталитического про-цесса. Витамин D может быть также получен из пищи, растительной (D2, или эргокальциферол) или животной (D3). В большинстве продуктов, за исключением жирных сортов рыбы, содержится незначительное количество витамина D. Since the discovery of vitamin D, interest in role of vitamin D in human body is consistently growing, and there is increasing evidence that vitamin D is not only essential to bone health but may also be involved in physiology of many other tissues. Thus understanding of its aspects in particular tissues appears to be important because of possible contribution to pathophysiologic processes. Intracrine regulatory systems associated with widely expressed vitamin D metabolizing enzymes, ways of cellular intake and signal pathways involved are of particular interest. Association of local effects with vitamin D level in blood is under investigation on animal models as well as in clinical studies; values of vitamin D level that mediate extraskeletal effects should be determined. In this review, we discuss impact of vitamin D on immune function and its association with skin, nervous system, cardiovascular system, obesity and diabetes mellitus, cancer, reproductive function, prevention of falls and quality of life improvement. НЕКЛАССИЧЕСКИЕ ЭФФЕКТЫ ВИТАМИНА D NON-CLASSICAL EFFECTS OF VITAMIN D

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Effect of Vitamin D Supplementation on Blood Pressure

Cited by 273 publications

References 74 publications

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Cardiovascular Effects of Long-Term Vitamin D Supplementation: Summarised by Many but Studied by Few

Non-classical effects of vitamin D

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