Effect of vitamin D supplement on depression scores in people
                        with low levels of serum 25-hydroxyvitamin D: nested case—control study and
                        randomised clinical trial

Kjærgaard, Marie; Waterloo, Knut; Wang, Catharina Elisabeth Arfwedson; Almås, Bjørg; Figenschau, Yngve; Hutchinson, Moira Strand; Svartberg, Johan; Jorde, Rolf

doi:10.1192/bjp.bp.111.104349

Cited by 181 publications

(180 citation statements)

References 39 publications

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“…More recent publications confirm this relationship: lower vitamin D levels are found in patients with depression [56][57][58]. One of the studies shows that vitamin D supplementation in depressed adolescent increases their wellbeing [56]. McCue et al reported that if vitamin D threshold was to be set at 30 ng/mL, as some suggest, the percentage of vitamin D deficient patients would increase from 52.3% (20 ng/mL) up to 85% [57].…”

Section: Affective Disordersmentioning

confidence: 57%

“…In 1979 a paper presented further correlation between vitamin D and depression -patients with depression-like symptoms (asthenia) had vitamin D deficiencies and were compared to a control group (non-asthenia group) [55]. More recent publications confirm this relationship: lower vitamin D levels are found in patients with depression [56][57][58]. One of the studies shows that vitamin D supplementation in depressed adolescent increases their wellbeing [56].…”

Section: Affective Disordersmentioning

confidence: 63%

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Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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Section: Affective Disordersmentioning

confidence: 57%

Section: Affective Disordersmentioning

confidence: 63%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…[39][40][41][42][43][44][45][46] Depression was not a requirement for inclusion in these studies. Based on low baseline depression scores, limited improvements in depression scales would be possible.…”

Section: Rctsmentioning

confidence: 99%

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs

Allan

Cranston²,

Lindblad

et al. 2016

J GEN INTERN MED

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Over the past decade, a large body of observational evidence has suggested an association between lower vitamin D status (25-hydroxyvitamin D) and multiple acute and chronic disorders, including cancer, multiple sclerosis, depression and respiratory tract infections. This evidence has fostered the hypothesis that increasing vitamin D intake may treat and prevent such disorders. Our objective was to perform a critical analysis of the highestlevel evidence for ten common beliefs regarding vitamin D for the prevention of falls, fractures and respiratory tract infections, the reduction of cancer incidence/mortality and overall mortality, and the prevention or treatment of depression/mental well-being, rheumatoid arthritis and multiple sclerosis, as well as maximum dosing and regular testing. We searched the Cochrane Database of Systematic Reviews and PubMed (up to August 2014) for randomized controlled trials and systematic reviews/ meta-analyses based on those studies. All searches were performed, all evidence reviewed and each section written by at least two authors. The evidence shows that vitamin D supplementation provides some benefit in fracture prevention (likely ∼10-15 % relative reduction), particularly at a dose ≥800 IU and with calcium; a likely benefit in the rate of falls, though it is less clear whether the number of fallers changes; and a possible small (∼5 %) relative reduction in mortality. Evidence does not support the use of vitamin D supplementation for the prevention of cancer, respiratory infections or rheumatoid arthritis. Similarly, evidence does not support vitamin D supplementation for the treatment of multiple sclerosis and rheumatoid arthritis or for improving depression/mental well-being. Regular testing of 25-hydroxyvitamin D is generally not required, and mega-doses (≥300,000 IU) appear to increase harms. Much of the evidence is at high risk of bias, with multiple flaws, including analyses of secondary endpoints, small and underpowered studies, inconsistent results and numerous other issues. Therefore, enthusiasm for a vitamin D panacea should be tempered.

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“…On the other hand, vitamin D is believed to play a role in serotonin activity. Vitamin D deficiency and insufficiency have been associated with clinically significant depressive symptoms 25,26 . In this study, we found 25(OH)D level of patients with depression lower compared to control group.…”

Section: Cmjmentioning

confidence: 99%

Hypovitaminosis D according to psychiatric diagnosis groups: A study with control group

Mert¹

2016

Cumhuriyet Med J

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SUMMARYObjective: One of the risk factor for different psychiatric disorders has been indicated as hypovitaminosis D. The present study aimed to compare 25 (OH) D level between 4 different types of psychiatric disorders (schizophrenia, bipolar disorder, depression and anxiety disorder) and healthy controls, and to assess the risk factors of hypovitaminosis D in psychiatric inpatients. Method: This retrospective study included 974 individuals [depression (n=553), bipolar disorder (n=135), schizophrenia (n=186) and anxiety disorder (n=100)] who received inpatient treatment in psychiatry clinic between 2012 and 2014, and 574 individuals in control group who were not diagnosed with a psychiatric condition. A 25 (OH) D level less than 21 ng/mL was considered to indicate hypovitaminosis D. Results: 25 (OH) D level average of the control group was found to be significantly higher than that of the four psychiatric diagnosis groups (p<0.05). There was no significant difference among 25 (OH) D level of psychiatric diagnosis groups (p<0.05). Comparing 25 (OH) D level among age groups in each study group, it was found that 25 (OH) D level of schizophrenic patients with an age range of 35-54 was found to be significantly lower than that of schizophrenic patients with an age range of 18-34 (p<0.05). 25 (OH) D levels by genders were lower among women in all diagnosis groups (p<0.05), while they were similar for both genders in control group (p>0.05). Logistic regression analysis of the study parameters suggested that the female gender (odds ratio: 3.46; 95% confidence interval: 0.99-1.01), winter and spring seasons (odds ratio: 2.56; 95% confidence interval: 1.69-3.86 and odds ratio: 2.03; 95% confidence interval: 1.33-3.11, respectively) were significant predictors in level of vitamin D in psychiatric inpatients. Conclusions: Hypovitaminosis D is a condition that frequently exists in inpatients in psychiatry clinic suffering from schizophrenia, bipolar disorder, anxiety disorder and d epression. Being a female, winter and spring are the most remarkable risk factors in these patients. Keywords: Hypovitaminosis D, schizophrenia, bipolar disorder, depression, anxiety Sonuç: Psikiyatri kliniğinde yatarak tedavi gören şizofreni, bipolar bozukluk, anksiyete ve depresyon hastalarında vitamin D eksikliği sıklıkla görülen bir durumdur. Bu hastalarda kadın olma ve kış-ilkbahar mevsimleri vitamin D eksikliği için en önemli risk faktörleri olarak belirlenmiştir.

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Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case—control study and randomised clinical trial

Abstract: Low levels of serum 25(OH)D are associated with depressive symptoms, but no effect was found with vitamin D supplementation.

Cited by 181 publications

References 39 publications

Application of fatty acid and lipid measurements in neuropsychiatry

Application of fatty acid and lipid measurements in neuropsychiatry

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs

Hypovitaminosis D according to psychiatric diagnosis groups: A study with control group

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