Effect of vitamin D replacement in chronic obstructive pulmonary disease patients with vitamin D deficiency

Rezk, Nasef Abdel Salam A.; Aly, Nasser Yehia A.; Hewidy, Asem A.

doi:10.1016/j.ejcdt.2015.01.002

Cited by 12 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, vitamin D supplementation may be beneficial in other population groups including those with existing chronic or inflammatory diseases. RCTs and systematic reviews of RCTs have shown that vitamin D supplementation improved inflammatory marker concentrations in patients with chronic heart failure 46 , systemic lupus erythematosus 47 , inflammatory bowel disease 48 , and chronic obstructive pulmonary disease 49 . Moreover, although RCTs in prediabetes have shown no effect of vitamin D supplementation on inflammatory markers 50 – 52 , a meta- analysis by our group in patients with type 2 diabetes found that vitamin D-supplemented groups had lower levels of CRP and TNF compared to placebo (Mousa, unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial

Mousa

Naderpoor

Johnson

et al. 2017

Sci Rep

View full text Add to dashboard Cite

In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFκB) activity. Yet, no trials have examined the effects of vitamin D supplementation on NFκB activity in-vivo in humans. We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NFκB activity in peripheral blood mononuclear cells (PBMCs). Sixty-five overweight/obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH)D] ≤ 50 nmol/L) adults were randomized to a single 100,000 IU bolus followed by 4,000 IU daily cholecalciferol or matching placebo for 16 weeks. We measured BMI, % body fat, serum 25(OH)D, high-sensitivity C-reactive protein (hsCRP), tumour necrosis factor (TNF), monocyte chemoattractant protein-1 (MCP-1), interferon-gamma (IFN-γ), several interleukins, and NFκB activity in PBMCs. Fifty-four participants completed the study. Serum 25(OH)D concentrations increased with vitamin D supplementation compared to placebo (p < 0.001). Vitamin D and placebo groups did not differ in any inflammatory markers or NFκB activity (all p > 0.05). Results remained non-significant after adjustment for age, sex, and % body fat, and after further adjustment for sun exposure, physical activity, and dietary vitamin D intake. Although in-vitro studies report anti-inflammatory effects of vitamin D, our RCT data show no effect of vitamin D supplementation on inflammatory markers or NFκB activity in-vivo in humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial

Mousa

Naderpoor

Johnson

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…At least 4,000 IU of vitamin D daily, during 2–3 months, are required to obtain optimal levels of this vitamin (212). Vitamin D supplementation seems to improve inflammatory marker concentrations in subjects with chronic disease such as heart failure (213), systemic lupus erythematosus (214), inflammatory bowel disease (215), and chronic obstructive pulmonary disease (216). Nevertheless, the lack of a biological effect of vitamin D on these markers could be explained by the health status of the study population (higher or lower grade of inflammation).…”

Section: Vitaminsmentioning

confidence: 99%

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

et al. 2019

View full text Add to dashboard Cite

Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition. Plant-based dietary patterns, functional foods, dietary supplements, and bioactive compounds such as the Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 and ω-6, vitamins E, A, C, and D, coenzyme Q10, as well as phytochemicals including isoflavones, stilbenes, and sterols have been associated with improvement in atheroma plaque at an inflammatory level. However, many of these correlations have been obtained in vitro and in experimental animals' models. On one hand, the present review focuses on the evidence obtained from epidemiological, dietary intervention and supplementation studies in humans supporting the role of immunonutrient supplementation and its effect on anti-inflammatory response in atherosclerotic disease. On the other hand, this review also analyzes the possible molecular mechanisms underlying the protective action of these supplements, which may lead a novel therapeutic approach to prevent or attenuate diet-related disease, such as atherosclerosis.

show abstract

“…Deficiency in 25-hydroxyvitamin D results from a number of causes and is associated with increased risk of infections including influenza, TB and pneumonia 7. On contrary Rezk et al15 in their study found a significant improvement in dyspnea scale (p < 0.003), coupled with a decrease in disease exacerbations (p < 0.001) and CRP (p < 0.001) a year after vitamin D replacement. However, the FEV1 and FVC did not differ significantly.…”

Section: Discussionmentioning

confidence: 88%

Role of Vitamin D in reducing number of acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients

et al. 2017

View full text Add to dashboard Cite

Background and Objective:Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of this study was to determine the effect of vitamin D supplementation in reducing number of acute exacerbation in COPD patients.Methods:This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore from January to December 2015 as exacerbations of COPD are season dependent. Diagnosis was confirmed by performing Pulmonary Function Tests (PFTs). Basic demographical information was obtained and baseline PFTs of the patient was done. Only Group A patients was treated with oral vitamin D intake of 2000 IU daily for 6 months. Vitamin D level was measured at 0, 2, 4, and 6 months and exacerbation of COPD, FEV1 and FVC was measured weekly. Both the groups were given standard treatment for exacerbation of COPD. Spirometry was repeated at each visit. Blood samples were collected every 2 months for vitamin D. Supplementation was stopped if vitamin D level exceeded 100ng/ml.Results:The mean age of the patients was 46.28±8.83 years, the male to female ratio was 1.8:1. The mean 25(OH) level at baseline was 24.08±2.58 and at 6th month was 29.60±8.74. The mean FVC at baseline was 77.83±5.49 and at 6th month was 91.34±5.52. The exacerbation at baseline was present in all 120(100%) patients and at 6th month was reduced to 4(3.3%).Conclusion:Vitamin D supplementation has significant effect in reducing number of acute exacerbation in COPD patients when it is given for prolonged period.

show abstract

Effect of vitamin D replacement in chronic obstructive pulmonary disease patients with vitamin D deficiency

Cited by 12 publications

References 23 publications

Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial

Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

Role of Vitamin D in reducing number of acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients

Contact Info

Product

Resources

About