Effect of Vitamin D Deficiency on Liver Cancer Risk: A Systematic Review and Meta-Analysis

Yi, Zhenghui; Wang, Linjie; Tu, Xiang-Qun

doi:10.31557/apjcp.2021.22.4.991

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Our results were supported by study of Yi et al [19] as they supported the idea that maintaining adequate blood vitamin D levels might help prevent liver cancer since vitamin D deficiency is thought to increase the risk of liver cancer. Kubesch et al [20] revealed that, the best threshold for predicting the likelihood of hepatic decompensation in patients with liver cirrhosis is 8.5 ng/mL of 25-OHD blood concentration, according to a study examining the correlation between vitamin D serum levels, systemic inflammation, and hepatic decompensation, they discovered a potentially functionally relevant connection between severe vitamin D deficiency, systemic inflammation, and the likelihood of hepatic decompensation in individuals with advanced liver cirrhosis.…”

Section: Discussionsupporting

confidence: 87%

Hypovitaminosis D and Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Rizk¹,

Mohamed²,

El-Alfy³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: The most frequent primary liver cancer in those with cirrhosis and chronic liver disease is hepatocellular carcinoma (HCC). Anti-infective and immune-modulating capabilities have been discovered for the multifunctional steroid hormone known as vitamin D. Vitamin D deficiency was found to be linked with advancement of Chronic liver disease (CLD) as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), as well as the hepatitis C virus (HCV). Objective: The aim of the current work was to investigate the association between vitamin D deficiency and HCC in patients with liver cirrhosis. Patients and Methods: Ninety individuals with liver cirrhosis (LC) participated in this trial. The included subjects were divided into two groups; Group A consisted of 45 cirrhotic patients without HCC, and Group B consisted of 45 cirrhotic patients with HCC. Results: Liver function tests: INR, ALT, AST, total bilirubin were all statistically substantially higher in group B than in group A (P=0.001, 0.001, 0.001, and 0.011, respectively). However, group B's serum albumin and platelet count were considerably lower than group A's (P=0.003 and 0.001, respectively) compared to each other. In comparison to group A's alphafetoprotein (AFP) of 8.69±1.84, group B's AFP of 254.33±32.69 was statistically substantially higher (P = 0.001).Vitamin D levels in group B were substantially lower (19.33±4.68) than in group A (26.31±4.95) (P= 0.00). With an area under the curve (AUC) of 0.802, vitamin D was significant at a cutoff level of ≤ 20.5 ng/ml with a sensitivity of 80.3% and a specificity of 75% for increasing the risk of HCC. Conclusion: It could be concluded that it is crucial to maintain an optimum blood level of vitamin D in cirrhotic individuals since our findings indicate a substantial correlation between vitamin D levels and HCC risk.

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Section: Discussionsupporting

confidence: 87%

Hypovitaminosis D and Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Rizk¹,

Mohamed²,

El-Alfy³

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…3 C). Finally, to better understand the potential role of vitamin D in liver cancer prediction, 30 levels of 25-OH vitamin D were analysed; we observed significantly lower baseline values in patients who later developed HCC ( Fig. 3 D).…”

Section: Resultsmentioning

confidence: 95%

Low HDL-cholesterol levels predict hepatocellular carcinoma development in individuals with liver fibrosis

et al. 2023

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“…A systematic review indicated that higher serum 25(OH)D was associated with a lower risk of HCC. 38 A prospective cohort study using the data from Finnish population-based health examination surveys FINRISK 1997 and Health 2000 (n=13,807) found that a 1 nmol/L increase in 25(OH)D concentration was associated with a lower risk of advanced liver disease (HR=0.972). 7 For mortality, most studies have focused on the association between serum vitamin D and all-cause mortality, cardiovascular mortality, and cancer-specific mortality, whereas the evidence for liver-related mortality was less reported.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D, type 2 diabetes, and liver-related outcomes: Secondary data analysis of a prospective recruited cohort

Wang,

Dan,

et al. 2023

Hepatology Communications

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Background: The association of vitamin D deficiency, which is prevalent in type 2 diabetes mellitus (T2DM), with liver disease and related mortality has not been quantified. Our study aimed to (1) investigate whether there is a synergistic association of vitamin D deficiency and T2DM with liver-related outcomes and (2) explore whether high 25-hydroxyvitamin D [25(OH)D] concentrations are associated with a lower risk of liver-related outcomes in T2DM. Method: Leveraging the data from UK Biobank, we conducted 2 studies: study I assessed the joint associations of vitamin D deficiency [25(OH)D <50 nmol/L] and T2DM with liver-related outcomes among 439,276 participants, and study II explored the associations of vitamin D status with liver-related outcomes among 21,519 individuals with T2DM. Baseline T2DM was identified through medication, laboratory test, and electronic health-related records. Serum 25(OH)D was measured by direct competitive chemiluminescent immunoassay. Liver-related outcomes included 6 liver disease end points and mortality by overall liver disease, chronic liver disease, and severe liver disease. Results: During an average follow-up duration of 11.6 years, we observed a significant positive additive interaction effect (all synergy index>1.0) of T2DM and vitamin D deficiency on the risk of liver-related outcomes. Compared with participants without either T2DM or vitamin D deficiency, the multivariable-adjusted HRs of overall liver diseases were 1.29 for participants without T2DM but with vitamin D deficiency, 1.73 for participants with T2DM but without vitamin D deficiency, and 2.19 for participants with both T2DM and vitamin D deficiency. In individuals with T2DM, we observed that participants without vitamin D deficiency were inversely associated with incident liver disease and related mortality (multivariable-adjusted HRs 0.41–0.81) when compared with individuals with vitamin D deficiency. Conclusions: There are positive synergistic associations of vitamin D deficiency and T2DM with liver-related outcomes. Inverse associations between serum 25(OH)D concentrations and liver-related outcomes were observed in individuals with T2DM.

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Effect of Vitamin D Deficiency on Liver Cancer Risk: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 32 publications

Hypovitaminosis D and Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Hypovitaminosis D and Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Low HDL-cholesterol levels predict hepatocellular carcinoma development in individuals with liver fibrosis

Serum 25-hydroxyvitamin D, type 2 diabetes, and liver-related outcomes: Secondary data analysis of a prospective recruited cohort

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