Effect of Vitamin C Supplementation on Postprandial Oxidative Stress and Lipid Profile in Type 2 Diabetic Patients

Mazloom, Zohreh; Hejazi, Najmeh; Dabbaghmanesh, Mohammad Hossein; Tabatabaei, H R; Ahmadi, Afsane; Ansar, Hastimansooreh

doi:10.3923/pjbs.2011.900.904

Cited by 49 publications

(35 citation statements)

References 12 publications

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“…obesity, resistance to insulin and hypertriglyceridemia [38]. However, in our study, like in other studies [39], lower LDL-C after a meal were accompanied by a decrease in LPO. The relation between LDL and LPO seems to be strict after a meal, as an exogenous oxidized cholesterol esters are directly incorporated into lipoproteins and transferred via the LDL into endothelial cells [40].…”

Section: Discussionsupporting

confidence: 85%

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome

et al. 2015

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BackgroundIn some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy).Methods36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apolipoproteins A-I, B, and hsCRP immunoturbidimetrically.ResultsThe postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (−19.5 ± 2.3 mg/dl) was greater than in healthy men (−5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-cholesterol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy.ConclusionIn men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.

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Section: Discussionsupporting

confidence: 85%

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome

et al. 2015

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“…In streptozotocin-induced diabetic rats, vitamin E reduces neuropathic pain by the modulation of oxidative stress in the dorsal root ganglia [ 119 ]. There is paucity of information on the role of vitamin C in DN despite evidence that it normalizes sorbitol concentration in the blood [ 117 ], scavenges lipid peroxides, and regenerates reduced glutathione in diabetes [ 120 – 124 ]. Similarly, from available literature, there is little information on the role of vitamin A in the management of DN.…”

Section: Antioxidant Strategies In Diabetic Neuropathymentioning

confidence: 99%

Antioxidant Strategies in the Management of Diabetic Neuropathy

Oyenihi

Ayeleso

Mukwevho

et al. 2015

BioMed Research International

127

116

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Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuropathy. Diabetic neuropathy (diabetes-induced nerve damage) is the most common diabetic complication and can be devastating because it can lead to disability. There is an increasing body of evidence associating diabetic neuropathy with oxidative stress. Oxidative stress results from the production of oxygen free radicals in the body in excess of its ability to eliminate them by antioxidant activity. Antioxidants have different mechanisms and sites of actions by which they exert their biochemical effects and ameliorate nerve dysfunction in diabetes by acting directly against oxidative damage. This review will examine different strategies for managing diabetic neuropathy which rely on exogenous antioxidants.

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“…Plasma vitamin C concentrations have been inversely correlated to glycosylated hemoglobin and fasting and postprandial blood glucose and oxidative stress, but not on lipid profiles [ 76 , 77 ]. Diabetes has also been associated to periodontal disease and vitamin C supplementation together with dental maneuvers has been shown to improve chronic periodontitis in newly diagnosed type 2 diabetic subjects [ 78 ].…”

Section: Vitamins and Diabetesmentioning

confidence: 99%

Vitamins and Type 2 Diabetes Mellitus

Valdés‐Ramos¹,

Laura²,

Elina³

et al. 2015

EMIDDT

142

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The present review evaluates the relationship between type 2 diabetes mellitus and individual or combined vitamins. Antioxidant vitamins A, C and E are found decreased in diabetic subjects, possibly due to an increased need to control the excessive oxidative stress produced by abnormalities in glucose metabolism. On the other hand, retinol binding protein exerts a modulating effect, as it has adipokine functions. With respect to the B group vitamins, thiamin, pyridoxine and biotin have been found decreased but the mechanisms are not clear, however supplementation has shown some improvement of the metabolic control in diabetic patients. The absorption of folic acid and vitamin B12 is importantly decreased by the prolongued use of metformin, which is the first choice drug in uncomplicated diabetes, thus these two nutrients have been found deficient in the disease and most probably need to be supplemented regularly. On the other hand, vitamin D is considered a risk factor for the development of diabetes as well as its complications, particularly cardiovascular ones. Although some studies have found an association of vitamin K intake with glucose metabolism further research is needed. Studies on the use of multivitamin supplements have shown unconclusive results. After reviewing the evidence, no real recommendation on the use of vitamin supplements in type 2 diabetes mellitus can be issued, however patients using metformin during prolongued periods may need folic acid and vitamin B12.

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Effect of Vitamin C Supplementation on Postprandial Oxidative Stress and Lipid Profile in Type 2 Diabetic Patients

Cited by 49 publications

References 12 publications

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome

Antioxidant Strategies in the Management of Diabetic Neuropathy

Vitamins and Type 2 Diabetes Mellitus

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