Effect of Vitamin C Supplementation on Oxidative Stress and Lipid Profiles in Hemodialysis Patients

Abdollahzad, Hadi; Eghtesadi, Shahryar; Nourmohammadi, I; Khadem-Ansari, Mohammad Hassan; Nejad-Gashti, Hossein; Esmaillzadeh, Ahmad

doi:10.1024/0300-9831.79.56.281

Cited by 47 publications

(36 citation statements)

References 24 publications

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“…However, not all have been evaluated in clinical trials pertaining to alleviation of oxidative stress and endothelial dysfunction. To date, most clinical trials investigating the effects of supplementation on oxidative stress and endothelial dysfunction have focused on the traditional exogenous antioxidants vitamins C and E. As with aerobic exercise training, antioxidant therapies utilizing vitamins C and E have been shown in clinical trials to reduce systemic biomarkers of oxidative stress in both healthy adults (Mah et al, 2013) and patients with preexisting vascular diseases (Abdollahzad et al, 2009). In addition, administration of vitamins C and E has been shown in some (Skyrme-Jones, O'Brien, Berry, & Meredith, 2000) but not all studies (McKechnie, Rubenfire, & Mosca, 2002;Title, Cummings, Giddens, Genest, & Nassar, 2000) to acutely improve flowmediated dilation (FMD) in patients with preexisting endothelial dysfunction.…”

Section: Antioxidant Supplementationmentioning

confidence: 98%

Reactive Oxygen and Nitrogen Species

Salisbury¹,

Bronas

2015

Nursing Research

109

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Section: Antioxidant Supplementationmentioning

confidence: 98%

Reactive Oxygen and Nitrogen Species

Salisbury¹,

Bronas

2015

Nursing Research

109

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“…Ghiadoni et al, first reported that oral intake of a single high dose of vitamin C (2000 mg) significantly reduced OS biomarkers and subsequently increased antioxidant capacity of HD patients within 2 hours . Two randomized, placebo‐controlled trials reported that daily oral administration of 250 mg of vitamin C significantly reduced oxidative products in serum . Yang et al, showed that iv administration of 1000 mg of vitamin C before each HD session significantly decreased HD‐evoked OS in a group of 80 HD patients, while another study reported that both iv infusion of vitamin C and use of dialysate rich in vitamin C in chronic maintenance HD patients played a significant protective role against the HD‐mediated OS …”

Section: Therapeutic Interventions With Antioxidantsmentioning

confidence: 99%

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

Liakopoulos

Roumeliotis

Zarogiannis

et al. 2018

Seminars in Dialysis

103

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Oxidative stress (OS) is the result of prooxidant molecules overwhelming the antioxidant defense mechanisms. Hemodialysis (HD) constitutes a state of elevated inflammation and OS, due to loss of antioxidants during dialysis and activation of white blood cells triggering production of reactive oxygen species. Dialysis vintage, dialysis methods, and type and condition of vascular access, biocompatibility of dialyzer membrane and dialysate, iron administration, and anemia all can play a role in aggravating OS, which in turn has been associated with increased morbidity and mortality. Oral or intravenous administration of antioxidants may detoxify the oxidative molecules and at least in part repair OS‐mediated tissue damage. Lifestyle interventions and optimization of a highly biocompatible HD procedure might ameliorate OS development in dialysis.

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“…This is mediated via their inhibition of cholesterol synthesis and LDL-cholesterol oxidation. [5860]…”

Section: Dietary Treatment Of Menopausementioning

confidence: 99%

The role of oxidative stress in menopause

Doshi¹,

Agarwal²

2013

J Mid-life Health

102

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This review will discuss the concept of reproductive aging, which includes the definition of menopause, its symptoms, and predisposing conditions. It will elaborate upon the contributory factors implicated in the pathogenesis of menopause, focusing most prominently on oxidative stress. Specifically, this paper will explain how oxidative stress, in the form of free radicals and antioxidant deficiencies, has been directly linked to the decline of estrogen during reproductive aging. Additionally, this paper will elaborate upon the treatment options aimed at mitigating the menopausal symptoms and hormonal deficiencies that can lead to various disease processes. Treatment options such as hormonal therapy, antioxidant supplementation, and lifestyle modification have been explored for their effectiveness in treating and preventing the symptoms and sequelae of menopause. The majority of information in this review was obtained through PubMed and the National Library of Medicine. While most references in this paper are original research articles, a limited number of references are comprehensive reviews on the topic.

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Effect of Vitamin C Supplementation on Oxidative Stress and Lipid Profiles in Hemodialysis Patients

Abstract: Every other day supplementation with 250 mg vitamin C for 12 weeks increases serum vitamin C, decreases MDA levels, and improves lipid profiles in hemodialysis patients.

Cited by 47 publications

References 24 publications

Reactive Oxygen and Nitrogen Species

Reactive Oxygen and Nitrogen Species

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

The role of oxidative stress in menopause

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