Effect of Vitamin C on Male Fertility in Rats Subjected to Forced Swimming Stress

Vijayprasad, Sanghishetti; Ghongane, Balasaheb B.; Bb, Nayak

doi:10.7860/jcdr/2014/8432.4622

Cited by 31 publications

(43 citation statements)

References 8 publications

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“…22 Both sperm progressive motility and total motility were significantly higher in infertile patients after 3 months of antioxidant treatment. Our findings are consistent with previous studies which demonstrated higher sperm motility in patients with idiopathic infertility following vitamin C, 23 vitamin E, 3,18,20 zinc, 10,18,24 selenium, 3,18 and coenzyme Q10 8,18,25 administration. A recent study has compared the effect of L-carnitine vs a combination of zinc, vitamin E, selenium, coenzyme Q10, glutathione, and L-carnitine and reported improvement in all seminal fluid measures after 3 months of combined treatment.…”

Section: Discussionsupporting

confidence: 93%

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Alahmar¹

2017

International Journal of Infertility &Amp; Fetal Medicine

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Introduction: Accumulating evidence suggests that oxidative stress plays an important role in the development of male infertil ity and recently antioxidants have been tried to treat men with idiopathic infertility. Objective: To assess the effect of treatment with vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 on seminal fluid parameters in infertile men with idiopathic oligoasthenozoo spermia. Materials and methods: A prospective randomized trial was conducted on 32 infertile men with idiopathic oligoasthenozoo spmia who received a daily supplement of one caplet contain ing vitamin C (90 mg/day), vitamin E (15 mg/day), coenzyme Q10 (4 mg/day), selenium (30 µg/day), and zinc (5 mg/day) for 3 months. Semen analysis was performed at baseline and 3 months after treatment using World Health Organization (WHO) 2010 guidelines. Results: Significant improvement in sperm concentration was observed after combination therapy (9.13 ± 4.29 vs 11.3 ± 6.05 × 10 6 /mL, p < 0.05). Sperm progressive motility (18.1 ± 8.68 vs 24.6 ± 10.2%, p < 0.01) and total motility (28.4 ± 8.71 vs 34.4 ± 11.7%, p < 0.01) also increased significantly following treatment. No change, however, was observed in semen volume or the proportion of sperms with normal morphology. Conclusion: The combination of vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 can significantly improve sperm concentration and motility in infertile men with idiopathic oligo asthenozoospermia, which could be attributed to their synergistic antioxidant action.

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Section: Discussionsupporting

confidence: 93%

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Alahmar¹

2017

International Journal of Infertility &Amp; Fetal Medicine

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“…Prasad et al [10] emphasized induction of oxidative stress by vitamins C, and E insufficiency, and demonstrated that vitamin C decreases oxidative stress via preserving integrity of membranes, and cellular functions. In a similar study protective effects of resveratrol against testicular injury induced by MTX on biochemical, histopathological, and apoptotic levels have been indicated.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C reinforces spermatogenesis. [9,10] In this study we aimed to investigate histopathologically whether vitamin C ameliorates deleterious effects of MTX on testicular tissue.…”

Section: Introductionmentioning

confidence: 99%

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Sayılmaz

Karabulut

Özgörgülü

2016

Turkish Journal of Urology

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Objective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis. Material and methods:A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i.p according to their groups. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histologic examination of each group. Results:The vitamin C + MTX group showed more similarity with the control group. Statistically significant results were achieved between groups as for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score. When compared with the group which received vitamin C after MTX therapy, values for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were significantly higher in the group which received vitamin C before initiation of MTX therapy. Conclusion:Vitamin C decreased MTX-induced testicular histological injuries, especially when used before MTX therapy.

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“…Vitamin C must be reasonably utilized to prevent side effects, including high serum uric acid, urinary tract stones, and reduced fertility have been reported [27].…”

Section: Vitamin Cmentioning

confidence: 99%

Role of Erythropoietin in Renal Anemia Therapy

Xing¹,

Zhang²,

Sun³

2016

Trop. J. Pharm Res

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Effect of Vitamin C on Male Fertility in Rats Subjected to Forced Swimming Stress

Cited by 31 publications

References 8 publications

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Role of Erythropoietin in Renal Anemia Therapy

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