Effect of vitamin C on endothelial function in health and disease: A systematic review and meta-analysis of randomised controlled trials

Nutrition and Atherosclerosis

“…However, the secondary prevention trial Women's Antioxidant Cardiovascular Study (WACS) did not find a benefit of 500 mg vitamin C/day on CVD (74). Nonetheless, a recent meta-analysis revealed that vitamin C supplementation improves endothelial function in atherosclerotic and heart failure patients, reducing CVD risk (75).…”

Inappropriate pattern of nutrient consumption and coexistent cardiometabolic disorders in elderly people from Poland

“…As an antioxidant, vitamin C affects the level of oxidative stress, thereby improving endothelial function. 20 Owing to poorer tolerance of raw vegetables and fruits by elderly patients, it is important to serve them in an easily digestible form rich in vitamin C. Patients with hypertension consumed also higher amounts of lauric acid (12:0), which is considered to be hypercholesterolemic. 21 Therefore, they should consider limiting the intake of high-fat dairy products, butter, and coconut oil.…”

Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

“…Vitamin C, an important physiological antioxidant, is essential for the synthesis of several biomolecules including collagen, carnitine, neurotransmitters and hormone, and for the metabolism of some amino acids and vitamins [15]. High doses of vitamin C have been associated with a reduced risk of cardiovascular disease [16], and an inverse relationship between plasma concentration of vitamin C and blood pressure has been reported [17]. Simultaneous ingestion of quercetin with vitamin C has been suggested to improve the bioavailability of quercetin [18], and supplementation with quercetin-vitamin C combination was effective in reducing oxidative stress and inflammatory biomarkers in human athletes [19].…”