Effect of vitamin C on neutrophil function after high‐intensity exercise

Krause, Robert; Patruta, Sanda; Daxböck, Florian; Fladerer, Petra; Biegelmayer, Ch.; Wenisch, Christoph

doi:10.1046/j.1365-2362.2001.00797.x

Cited by 25 publications

(21 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study of 12 marathoners, who ran for 2.5 h on treadmills after receiving either vitamin C or placebo supplementation, revealed no differences in the pattern of changes in hormonal and immune values (including natural killer cell activity, mitogen-stimulated lymphocyte proliferation, granulocyte/monocyte phagocytosis and oxidative burst activity, leukocyte subsets, and IL-6) . Krause et al (2001) reported no effects of vitamin C supplementation (2000 mg/day for 1 week) on neutrophil phagocytosis and bactericidal ability following a competitive biathlon (16 km uphill cycling and 2 km uphill running). However, that study did not include a placebo supplement, and subjects were not randomized to treatment conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies have failed to show an influence of vitamin C supplements on immune changes following intense endurance exercise (Krause et al 2001;Nieman et al 1997Nieman et al , 2002Petersen et al 2001). In the present study, we also examined immune cell counts, plasma concentrations of interleukins IL-6, IL-10, IL-1ra, and IL-8, mitogen-stimulated lymphocyte proliferation, and IL-2 and interferon gamma (IFN-c) production (Nieman et al 2002).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon

et al. 2003

View full text Add to dashboard Cite

This randomized study measured the influence of vitamin C ( N=15) compared to placebo ( N=13) supplementation on oxidative and salivary immunoglobulin A (sIgA) changes in runners competing in an ultramarathon race. Seven days prior to the race, subjects ingested in randomized, double-blind fashion three 500-mg tablets of vitamin C or placebo each day. On race day, blood and saliva samples were collected 1 h pre-race, after 32 km of running, and then again immediately post-race. During the race, runners received 1 l/h carbohydrate beverages (60 g/l) with vitamin C (150 mg/l) or without in a double-blinded fashion. The runners also ingested two to three carbohydrate gel packs per hour (25 g each). Subjects in both groups ran a mean of 69 km (range 48-80 km) in 9.8 h (range 5-12 h) and maintained an intensity of approximately 75% maximal heart rate (HR(max)) throughout the ultramarathon race. Plasma ascorbic acid was higher in the vitamin C compared to placebo group pre-race, and increased significantly in the vitamin C group during the race [post-race, 3.21 (0.29) and 1.28 (0.12) microg/100 microl, respectively, P<0.001]. No significant group or interaction effects were measured for lipid hydroperoxide and F(2)-isoprostane, but both oxidative measures rose significantly during the ultramarathon race. Saliva volume, sIgA concentration, sIgA secretion and sIgA:saliva protein ratio all decreased significantly (P<0.001) during the race, but the pattern of change in all saliva measures did not differ significantly between groups. No significant correlations were found between post-race plasma vitamin C, oxidative, and saliva measures, except for a positive correlation between post-race serum cortisol and serum vitamin C (r=0.50, P=0.006). These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and sIgA changes during or following a competitive ultramarathon race.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon

et al. 2003

View full text Add to dashboard Cite

show abstract

“…The natural antioxidant systems that protect neutrophils could be depleted after intensive exercise, and the oxidative burst cannot then be carried out in an effective way. The supplementation with vitamin C or beta-carotene plus vitamin C and E failed, however, to show consistent results in improving oxidative burst activity (Nieman et al, 1997b;Krause et al, 2001;Robson et al, 2003).…”

Section: Antioxidants and Vitaminsmentioning

confidence: 99%

“…The interventions in the other four studies had no effect on NKCA. Two trials showed increased neutrophil oxidative burst activity after a 3-week supplementation period with multivitamin-minerals, including beta-carotene and vitamins C and E (Scharhag et al, 2002) and a 12% CHO beverage (Robson et al, 2003), but this was not observed in the other four studies where vitamin C (Nieman et al, 1997b;Krause et al, 2001), glutamine (Walsh et al, 2000) or CHO (Nieman et al, 1997a) were used. Lipopolysaccharide- Figure 5 Effectiveness of nutritional interventions compared with placebo on neutrophils counts (10 9 L À1 ) after exercise.…”

Section: Nutrition and Exercise-induced Immunodepressionmentioning

confidence: 99%

Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis

et al. 2006

View full text Add to dashboard Cite

Background: Heavy exercise induces marked immunodepression that is multifactorial in origin. Nutrition can modulate normal immune function. Objective: To assess the efficacy of nutritional supplements in exercise-induced immunodepression in athletes. Design: Systematic review. Review methods: Randomised and/or controlled trials of athletes undertaking nutritional supplements to minimise the immunodepression after exercise were retrieved. The primary outcome measure was incidence of upper respiratory tract (URT) illness symptoms after exercise, and secondary outcomes included cortisol, cell counts, plasma cytokine concentration, cell proliferative response, oxidative burst, natural killer cell activity and immunoglobulins. When data were available for a pooled estimate of the effect of intervention, meta-analyses were conducted for direct comparisons. Results: Forty-five studies were included (1603 subjects). The studies were heterogeneous in terms of exercise interventions, selection of athletes, settings and outcomes. The overall methodological quality of most of the trials was poor. Twenty studies addressed carbohydrate supplementation, eight glutamine, 13 vitamin C and four others interventions. Three trials assessed the effect of intervention on prevention of URT infections. The pooled rate ratio for URT infections after vitamin C supplementation against placebo was 0.49 (0.34-0.71). Carbohydrate supplementation attenuated the increase in cortisol and neutrophils after exercise; vitamin C attenuated the decrease in lymphocytes after exercise. No other interventions had significant or consistent effect on any of the studied outcomes. Conclusions: Although the prevention of URT infections by vitamin C was supported by two trials, further studies are needed. The available evidence failed to support a role for other nutritional supplements in preventing exercise-induced immune suppression. Larger trials with clinically relevant and uniform end points are necessary to clarify the role of these nutritional interventions.

show abstract

“…Exercise-related immunological acute changes include release of cytokines (Petersen et al 2001), activation of immunocompetent cell lines (Suzuki et al 1999), neutrophil priming for acute phase response (Cannon and Blumberg 2000;Suzuki et al 1999) and lower antioxidant enzyme levels in neutrophils (Tauler et al 2002a). The eVects of nutritional antioxidants on the endogenous antioxidant response to oxidative stress as well as on exercised-induced acute changes in immune cell function have been pointed out (Krause et al 2001;Morante et al 2005;Sastre et al 1992;Tauler et al 2003a, b). Recent data indicate that contraction-induced ROS modulates at least some of the adaptative responses that occur in skeletal muscle following contractile activity (McArdle et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer

et al. 2008

View full text Add to dashboard Cite

The aim of the study was to determine the effects of an antioxidant supplementation, which includes coenzyme Q(10), on plasma and neutrophil oxidative stress and the antioxidant response after a soccer match. Nineteen voluntary male pre-professional footballers were randomly and double-blinded treated with either a multivitamin and mineral supplement (n = 8) or a placebo (n = 11). After the 3 months of supplementation, the sportsmen played a friendly soccer match of 60 min. The 3-month supplementation induced higher plasma ascorbate and coenzyme Q levels when compared to the placebo group. Antioxidant supplementation influenced plasma oxidative stress markers because they were lower in the supplemented group than in the placebo one after the match. The football match induced decreased neutrophil vitamin E levels and catalase and glutathione peroxidase activities but increased glutathione reductase activity. Antioxidant diet supplementation prevented plasma oxidative damage but did not influence the neutrophil response to a football match.

show abstract

Effect of vitamin C on neutrophil function after high‐intensity exercise

Cited by 25 publications

References 35 publications

Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon

Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon

Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis

Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer

Contact Info

Product

Resources

About