Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Ellulu, Mohammed S.; Rahmat, Asmah; Patimah, Ismail; Khaza’ai, Huzwah; Abed, Yacine

doi:10.2147/dddt.s83144

Cited by 155 publications

(99 citation statements)

References 34 publications

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“…A small study conducted last year on 64 Palestinian men and women who were obese and hypertensive and/or diabetic yielded similar results [24]. Participants were randomized into an experimental group, which received 500 mg vitamin C twice daily, or a control group that received no supplement.…”

Section: Clinical Trialsmentioning

confidence: 99%

Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

Moser

Chun

2016

IJMS

169

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Vitamin C is a powerful dietary antioxidant that has received considerable attention in the literature related to its possible role in heart health. Although classical vitamin C deficiency, marked by scurvy, is rare in most parts of the world, some research has shown variable heart disease risks depending on plasma vitamin C concentration, even within the normal range. Furthermore, other studies have suggested possible heart-related benefits to vitamin C taken in doses beyond the minimal amounts required to prevent classically defined deficiency. The objective of this review is to systematically review the findings of existing epidemiologic research on vitamin C and its potential role in cardiovascular disease (CVD). It is well established that vitamin C inhibits oxidation of LDL-protein, thereby reducing atherosclerosis, but the cardiovascular outcomes related to this action and other actions of vitamin C are not fully understood. Randomized controlled trials as well as observational cohort studies have investigated this topic with varying results. Vitamin C has been linked in some work to improvements in lipid profiles, arterial stiffness, and endothelial function. However, other studies have failed to confirm these results, and observational cohort studies are varied in their findings on the vitamin’s effect on CVD risk and mortality. Overall, current research suggests that vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels. However, the current literature provides little support for the widespread use of vitamin C supplementation to reduce CVD risk or mortality.

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Section: Clinical Trialsmentioning

confidence: 99%

Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

Moser

Chun

2016

IJMS

169

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“…Neutrophils are the major source of myeloperoxidase in the body (Davies et al, 2008), with much lower levels found in monocytes and possibly macrophages (Davies et al, 2008;van der Veen et al, 2009), and it is an excellent biomarker of neutrophil activation (Stamp et al, 2012). Vitamin C is a potent scavenger of reactive oxygen species, including those generated by myeloperoxidase (Carr & Frei, 1999), and it has other antiinflammatory activities (Block et al, 2009;May & Harrison, 2013;Ellulu et al, 2015;Jamalan et al, 2015). The primary objective of our study was to determine the myeloperoxidase levels in human semen and correlate this with semen quality, including DNA damage, in a group of young men unscreened for fertility issues.…”

Section: Introductionmentioning

confidence: 99%

Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men

et al. 2017

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Myeloperoxidase is a major neutrophil protein which generates oxidants that are highly reactive, and if present in seminal fluid, could be potentially damaging to spermatozoa. We recruited young males aged 18-35 years, unscreened for fertility status, for a pilot study measuring seminal plasma myeloperoxidase. On three occasions, over a 3-month period, we measured parameters of semen quality and correlated these with seminal myeloperoxidase protein and activity. After baseline measurement, participants were supplemented daily with 250 mg of vitamin C, a potent scavenger of reactive oxygen species with antiinflammatory activities. Seminal plasma from eight of the 12 participants had measurable concentrations of myeloperoxidase protein, across a broad range (15-250 ng/mL). Median myeloperoxidase protein concentrations were ~45-fold higher in semen samples with low vs. high sperm concentrations. Seminal plasma myeloperoxidase protein concentration was inversely correlated with the percentage of rapidly motile spermatozoa assessed by computer-assisted sperm analysis, and the total number of spermatozoa per ejaculate, but positively correlated with sperm maturity, measured by DNA staining ability. We measured an inverse correlation between semen vitamin C concentration and seminal plasma myeloperoxidase protein concentration, although vitamin C supplementation had no effect on semen quality. Our pilot data suggest that high concentrations of myeloperoxidase were present in the seminal plasma of many of our young participants, and that this may be associated with decreases in semen quality. A larger study is required to confirm these findings.

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“…Through donation of an electron, vitamin C functions as a cofactor in several enzymatic reactions, and neutralizes free radicals (81). Of note, while dietary vitamin C was significantly associated with lower CRP concentrations, dietary plus supplemental vitamin C was not, suggesting that the association may be due to other constituents in foods high in vitamin C, e.g., polyphenols, rather than vitamin C specifically.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Multiple Biomarkers of Systemic Inflammation

Navarro

Kantor

Song

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background While much is known about correlates of C-reactive protein (CRP), little is known about correlates of other inflammation biomarkers. As these measures are increasingly being used in epidemiologic studies, it is important to determine what factors affect inflammation biomarker concentrations. Methods Using age, sex and body mass index (BMI) adjusted linear regression, we examined 38 exposures (demographic and anthropometric measures, chronic disease history, NSAIDs, dietary factors, supplement use) of 8 inflammation biomarkers [CRP, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), and soluble TNF receptors (sTNFR) in plasma; and prostaglandin E2 –metabolite (PGE-M) in urine] in 217 adults, aged 50-76 years. Results Increasing age was associated with higher concentrations of all biomarkers except IL-1β. BMI was positively associated with CRP and sTNFR I and II. Saturated fat intake was associated with increased CRP, sTNFRII, TNF-α, and IL-1β, while EPA+DHA intake (diet or total) was associated with decreased CRP, TNF-α, and IL-1β. Results for sex were varied: CRP and IL-6 were lower among men, whereas PGE-M and sTNFRI were higher. Higher CRP was also associated with smoking, HRT use, and γ-tocopherol intake; lower CRP with physical activity, and intakes of dietary vitamin C and total fiber. Conclusions Although the associations varied by biomarker, the factors having the greatest number of significant associations (p<=0.05) with the inflammation biomarkers were age, BMI, dietary saturated fat and EPA+DHA omega 3 fatty acids. Impact Our results suggest that potential confounders in epidemiologic studies assessing associations with inflammation biomarkers vary across specific biomarkers.

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Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Cited by 155 publications

References 34 publications

Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men

Factors Associated with Multiple Biomarkers of Systemic Inflammation

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