Effect of vitamin B12 on pantothenic acid metabolism in the chick

Evans, Robert J.; Groschke, A. C.; Butts, Helen A.

doi:10.1016/0003-9861(51)90163-4

Cited by 16 publications

(9 citation statements)

References 5 publications

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“…The moisture, nitrogen, starch, total sugar, ash, crude fiber, and oil contents were determined by the methods of the Association of Official Agricultural Chemists (7). Nitrogen solubility was determined by the method of Lyman, Chang, and Couch (70).…”

mentioning

confidence: 99%

Heat Effects on Peas, Effect of Autoclaving on the Basic Amino Acids and Proteins of the Chick Pea

Cueto¹,

Martinez²,

Frampton³

1960

J. Agric. Food Chem.

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The work reported grew out of an interest in the effects of heat on the nutritive quality of plant proteins. Lysine is the limiting amino acid in most rations in which cereals are the source of energy. Because the chick pea, a typically starchy seed, is rich in lysine and is an important food crop, interest developed in the effects of heat on the nutritive quality of its proteins in comparison with typical oilseeds. About 25% of the chick pea is protein, rich in lysine (6.5 to 6.7%). The lysine content is reduced about 1 0% when the seeds are heated in the autoclave to 121 0 C. for 30 and 60 minutes. The reduction is greater the less the moisture content of the seed.Usually the nutritional quality of oilseed meal proteins is improved when heating of the seed during processing for oil is moderate ( 9), but amino acids, especially lysine, cystine, and arginine, are destroyed when heating is severe.

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mentioning

confidence: 99%

Heat Effects on Peas, Effect of Autoclaving on the Basic Amino Acids and Proteins of the Chick Pea

Cueto¹,

Martinez²,

Frampton³

1960

J. Agric. Food Chem.

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“…The sparing effect of Bi 2 on pantothenic acid demonstrated here may be explained by the theory offered by Evans, Groschke and Butts (1951). They postulated that the higher pantothenic acid content found in livers of chicks fed vitamin Bi 2 -deficient diets in their trials was because vitamin B 12 may aid in the transfer of pantothenic acid from the liver for use elsewhere in the chick's body.…”

Section: Resultsmentioning

confidence: 62%

“…In view of the reports of Evans et al (1951), Yacowitz et al (1951) and Welch and Couch (1954) regarding the relationship between vitamin B 12 and pantothenic acid in the nutrition of the young chick, it was thought desirable to investigate possible interaction of these two vitamins in the nutrition of breeder hens.…”

Section: Department Of Poultry Husbandry Iowa State College Amesmentioning

confidence: 98%

Interaction Effects of Vitamin B12 and Pantothenic Acid in Breeder Hen Diets on Hatchability, Chick Growth and Livability

Balloun

Phillips

1957

Poultry Science

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“…Yacowitz, Norris & Heuser (1951) had reported a sparing action by vitamin B12 for pantothenic acid in chicks. That vitamin B12 may also aid in the transfer of pantothenic acid from livers of chicks was suggested by Evans, Groschke & Butts (1951). More recently, it has been observed by Boxer, Ott & Shonk (1953) that there is a fivefold increase in coenzyme A concentration in livers of vitamin B12deficient chicks.…”

Section: Dietmentioning

confidence: 96%

Observations on the relationship between pteroylglutamic acid and nicotinamide metabolism

Marfatia

Sreenivasan

1955

Biochemical Journal

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Slightly depressed growth and fatty livers have been reported in rats fed moderate amounts of nicotinamide, together with a low protein diet (Handler & Danm, 1942; Handler & Bemheimn, 1943). The fatty livers were susceptible to the action of choline, while methionine was found to alleviate the growth inhibition. Since excess of nicotinamide is detoxicated and eliminated as urinary N1-methylnicotinamide, the observed toxicity of nicotinamide at unphysiological levels of feeding was attributed to forced methylation and consequent depletion of labile methyl reserves (Handler, 1944). In agreement with this, Handler observed no signs of toxicity as a result of ingestion of large quantities of nicotinamide by young rabbits or guinea pigs, neither of which species excrete NL-methylnicotinamide (Handler, 1944). Production of fatty livers by feeding excessive amounts of glycocyamine, cystine or homocystine have also been reported (du Vigneaud, Chandler, Moyer & Keppel, 1939; du Vigneaud, Chandler, Cohn & Brown, 1940; Stetten & Grail, 1942). More recently, it has been shown that, in the pyridine-fed rat, there is a decreased urinary excretion of creatine owing to a reduction of available methyl groups, pyridine being detoxi-cated as N-methylpyridinium hydroxide (Dinning, Keith, Parsons & Day, 1950). The known mediation of pteroylglutamic acid in biological methylations including the methylation of nicotinamide (Fatterpaker, Marfatia & Sreenivasan, 1951, 1952a, 1954; Dietrich, Monson & Elvehjem, 1952) suggested the present studies on its influence on the extent of depletion of methyl reserves in rat livers consequent on ingestion of excessive amounts of nicotinamide. The studies included observations on a number of other substances and enzymes expected to be influenced by changes in pteroylglutamic acid or available labile methyl compounds. Pteroylglutamic acid deficiency was induced in the first set of experiments by dietary means, while in the second series aminopterin feeding was used. In the first series, additional groups with choline supplementation were included. EXPERIMENTAL Methods Urinary excretions of creatine (Clark & Thompson, 1949), Nl-methylnicotinamide (Huff & Perlzweig, 1947) and total nicotinic acid (Swaminathan, 1946), liver N (Johnson, 1941), This work was aided by a grant from the Indian Council of Medical Research. Our thanks are due to Lederle Laboratories Inc. (New York), Chas. Pfizer and Co. Inc. (New York), Glaxo Laboratories Ltd. (Greenford), and Boots Pure Drug Co. Ltd. (Nottingham) for valuable gifts of chemicals.

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Effect of vitamin B12 on pantothenic acid metabolism in the chick

Cited by 16 publications

References 5 publications

Heat Effects on Peas, Effect of Autoclaving on the Basic Amino Acids and Proteins of the Chick Pea

Heat Effects on Peas, Effect of Autoclaving on the Basic Amino Acids and Proteins of the Chick Pea

Interaction Effects of Vitamin B12 and Pantothenic Acid in Breeder Hen Diets on Hatchability, Chick Growth and Livability

Observations on the relationship between pteroylglutamic acid and nicotinamide metabolism

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