Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms

Dror, Daphna K; Allen, Lindsay H.

doi:10.1111/j.1753-4887.2008.00031.x

Cited by 391 publications

(423 citation statements)

References 45 publications

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“…Vitamin B12 has a role in axon myelination that is important for impulse conduction from cell to cell, and it also protects neurons from degeneration. Vitamin B12 may also alter the synthesis of different cytokines, growth factors and oxidative energy metabolites such as lactic acid (Dror and Allen, 2008).…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

“…A pooled analysis that included 48 case studies of infants with vitamin B12 deficiencies reported a variety of abnormal clinical and radiological signs, including: hypotonic muscles, involuntary muscle movements, apathy, cerebral atrophy, and demyelination of nerve cells (Dror and Allen, 2008). After vitamin B12 treatment, a rapid improvement in neurological symptoms is reported in deficient infants, but many of these infants remained seriously delayed in cognitive and language development in the longer term (Dror and Allen, 2008). The long-lasting effect of vitamin B12 deficiency is supported by the findings of Louwman et al (2000).…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

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The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

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This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive development in childhood. Earlier studies which have investigated the association between nutrition and cognitive development have focused on individual micronutrients, including omega-3 fatty acids, vitamin B12, folic acid, choline, iron, iodine, and zinc, and single aspects of diet. The research evidence from observational studies suggests that micronutrients may play an important role in the cognitive development of children. However, the results of intervention trials utilizing single micronutrients are inconclusive. More generally, there is evidence that malnutrition can impair cognitive development, whilst breastfeeding appears to be beneficial for cognition. Eating breakfast is also beneficial for cognition. In contrast, there is currently inconclusive evidence regarding the association between obesity and cognition. Since individuals consume combinations of foods, more recently researchers have become interested in the cognitive impact of diet as a composite measure. Only a few studies to date have investigated the associations between dietary patterns and cognitive development. In future research, more well designed intervention trials are needed, with special consideration given to the interactive effects of nutrients.

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Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

View full text Add to dashboard Cite

show abstract

“…Food intake and the over-or undersupply of specific nutrients have been linked to various diseases such as obesity, type II diabetes, cardiovascular disease, celiac disease and failure to thrive particularly in children (Romieu and Trenga, 2001;Dror and Allen, 2008;Mangione and Patel, 2008;Salas-Salvadó et al, 2008;Virtanen et al, 2008;Symonds, 2009). It is well known that dietary intake information can be difficult to collect from study subjects (Goldbohm et al, 1995;Rockett et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Validation of photographic food records in children: are pictures really worth a thousand words?

et al. 2009

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Background/Objectives: Self-reported food records are commonly used to estimate dietary intake. However, diet diaries are time consuming for participants and children are often unfamiliar with standard portion sizes or weights/volume of foods that can add to the error associated with self-reported intake. We hypothesize that photographic food records to assess dietary intake will be as accurate as a standard food diary and will decrease participant/family burden. Subjects/Methods: A total of 28 healthy subjects, 10-16 years, consumed a weighed diet for 3 days and returned any uneaten items for weigh back on day 4. During the 3 days of weighed diet, subjects recorded all intake both using a standard diet diary and taking photographs before and after consumption. Photographs were analyzed by two independent dieticians for estimation of serving size. The actual amount consumed was compared to the diary and photographic estimates through Spearman's correlation coefficients and confidence intervals. Results: There was no difference between the diet diary and photographic estimates of total energy, carbohydrate, fat, protein, fiber, vitamins A, D and E, calcium, iron or zinc compared to actual intake. However, both participants and their parents reported that the photographic method was quicker, simpler and would be preferred if they were to record dietary intake in the future. In this study cohort, 36% of subjects accurately reported actual daily energy intake ( ± 5% of actual intake), only 29% underreported energy intake and 35% overreported energy intake. Conclusions: Photographic food records can be used to accurately estimate dietary intake in a pediatric population. In addition, this method is less burdensome for the participants and their family.

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“…Because of the interactions with folate metabolism, vitamin B 12 is indirectly involved in neurotransmitter synthesis. Furthermore, the vitamin B 12 cofactors adenosylcobalamin and methylcobalamin are involved in myelination of the spinal cord and the brain (29) . The primary objective of the present study is to investigate the associations between indicators of body size, fatty acid status, and Fe, iodine and B-vitamin status on overall cognitive performance in 598 Indian school-age children.…”

mentioning

confidence: 99%

Undernutrition, fatty acid and micronutrient status in relation to cognitive performance in Indian school children: a cross-sectional study

et al. 2009

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While undernutrition and anaemia have previously been linked to poor development of children, relatively little is known about the role of B-vitamins and fatty acids on cognition. The present study aims to explore the associations between indicators of body size, fatty acid and micronutrient status on cognitive performance in 598 Indian school children aged 6 -10 years. Baseline data of a clinical study were used to assess these associations by analyses of variance adjusting for age, sex, school, maternal education and cognitive tester. The Kaufman Assessment Battery for Children II was used to measure four cognitive domains, including fluid reasoning, short-term memory, retrieval ability and cognitive speediness. Scores were combined into an overall measure, named mental processing index (MPI). Body size indicators and Hb concentrations were significantly positively related to cognitive domains and MPI, such that increases of 1 SD in height-for-age and weight-for-age z-scores would each translate into a 0·09 SD increase in MPI, P¼0·0006 and 0·002, respectively. A 10 g/l increase in Hb concentrations would translate into a 0·08 SD increase in MPI, P¼ 0·0008. Log-transformed vitamin B 12 concentrations were significantly inversely associated with short-term memory, retrieval ability and MPI (b (95 % CI) ¼ 20·124 (20·224, 20·023), P¼ 0·02). Other indicators of Fe, iodine, folate and fatty acid status were not significantly related to cognition. Our findings for body size, fatty acids and micronutrients were in agreement with previous observational studies. The inverse association of vitamin B 12 with mental development was unexpected and needed further study.

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Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms

Cited by 391 publications

References 45 publications

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Validation of photographic food records in children: are pictures really worth a thousand words?

Undernutrition, fatty acid and micronutrient status in relation to cognitive performance in Indian school children: a cross-sectional study

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