Effect of vitamin A supplementation on hematopoiesis in children with anemia

Garg, Arun; Abrol, Pankaj; Tewari, AD; Sen, Ruchira; Lal, Harbans

doi:10.1007/bf02893048

Cited by 7 publications

(7 citation statements)

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“…Reasonable number of Randomized Controlled Trials (RCTs) based on daily or weekly VA Supplementation (VAS) have also concluded likewise [8-12]. However, RCTs based on single high dose VAS concluded equivocally.…”

Section: Introductionmentioning

confidence: 99%

“…Several observational studies witnessed significant association between hemoglobin and various VA status indicators [ 6 ]. Reasonable number of Randomized Controlled Trials (RCTs) based on daily or weekly VA Supplementation (VAS) have also concluded likewise [ 8 - 12 ]. However, RCTs based on single high dose VAS concluded equivocally.…”

Section: Introductionmentioning

confidence: 99%

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Effect of a single high dose vitamin A supplementation on the hemoglobin status of children aged 6–59 months: propensity score matched retrospective cohort study based on the data of Ethiopian Demographic and Health Survey 2011

Gebremedhin

2014

BMC Pediatr

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BackgroundVitamin A deficiency can cause anemia as the nutrient is essential for hematopoiesis, mobilization of iron store and immunity. Nevertheless, clinical trials endeavored to evaluate the effect of Vitamin A Supplementation (VAS) on hemoglobin concluded inconsistently. Accordingly, the objective of the current study is to assess the effect of single high dose VAS on the hemoglobin status of children aged 6–59 months.MethodsThe study was conducted based on the data of Ethiopian Demographic Health Survey 2011. The data from 2397 children aged 6–59 months who received a single dose of 30 or 60 mg of VAS (depending on age) in the preceding 6 months were matched with similar number children who did not receive the supplement in the reference period. The matching was based on propensity scores generated from potential confounders. Distributions of hemoglobin concentration and risks of anemia were compared between the groups using paired t-test, matched Relative Risk (RR) and standardized mean difference.ResultThe supplemented and non-supplemented groups were homogeneous in pertinent socio-demographic variables. Compared to propensity score matched non-supplemented children, those who received vitamin A had a 1.50 (95% CI: 0.30-2.70) g/l higher hemoglobin concentration (P = 0.014). In the supplemented and non-supplemented groups, the prevalences of anemia were 46.4% and 53.9%, respectively. VAS was associated with a 9% reduction in the risk of anemia (RR = 0.91 (95% CI: 0.86-0.96)). Stratified analysis based on household wealth status indicated that the association between VAS and hemoglobin status was restricted to children from the poor households (RR = 0.74 (95% CI: 0.61-0.90)). Effect size estimates among all children (Cohen’s d = 0.07) and children from poor households (d = 2.0) were modest.ConclusionSingle high dose VAS among Ethiopian children 6–59 months of age was associated with a modest increase in hemoglobin and decrease in risk of anemia. Household wealth status may modify the apparent association between VAS and hemoglobin status.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of a single high dose vitamin A supplementation on the hemoglobin status of children aged 6–59 months: propensity score matched retrospective cohort study based on the data of Ethiopian Demographic and Health Survey 2011

Gebremedhin

2014

BMC Pediatr

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“…36 Some researchers have suggested that vitamin A plays a role in the metabolism of iron; for this reason, many countries have developed supplementation strategies for both iron and vitamin A to reduce the prevalence of anemia. 41 Although the exact interaction of iron and vitamin A is not well known, 23,40 several mechanisms have been suggested, including the regulation of either hematopoiesis 19,24 or various proteins related to iron homeostasis (for example, transferrin, 26 iron regulatory protein 2, 23 and hepcidin). 6,13,15 We conducted this study based on the hypothesis that both vitamin A and iron must be taken together to ensure adequate weight gain and hematologic parameters.…”

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confidence: 99%

Influence of Dietary Vitamin A and Iron Deficiency on Hematologic Parameters and Body Weight of Young Male Wistar Rats

Restrepo-Gallego¹,

Díaz²

2020

j am assoc lab anim sci

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Micronutrient deficiency is one of the most prominent public health concerns; in particular, vitamin A and iron are determinants of appropriate development, and vitamin A influences iron homeostasis and metabolism. Here we compared the effects of diets that were sufficient and insufficient in vitamin A and iron on the hematologic parameters and body weight of rats. Male Wistar rats were randomly divided into 5 dietary groups (n = 7 per group): adequate in iron and vitamin A (control); adequate in iron but low in vitamin A (FesvAi); adequate in iron but lacking vitamin A (FesvAd); low in iron but adequate in vitamin A (FeivAs); and low in both iron and vitamin A (FeivAi). After 6 wk, rats showed significant differences in serum iron relative to the control diet (control, 256 ± 44 μg/dL; FesvAi, 220± 16 μg/dL; FesvAd, 181 ± 15 μg/dL; FeivAs, 131 ± 44 μg/dL; FeivAi, 75 ± 19 μg/dL). Rats on iron-deficient diets showed reduced Hgb values relative to the control diet (control, 15.9 ± 0.7 g/dL; FeivAs, 13.2 ± 1.6 g/dL; FeivAi, 12.9 ± 1.0 g/dL), MCV (control: 57 ± 10 fL; FeivAs, 48 ± 10 fL; FeivAi, 44 ± 3 fL), and Hct (control, 53% ± 2%; FeivAs, 44% ± 5%; FeivAi, 42% ± 8%). All of the experimental dietary groups showed significant differences in reticulocyte count when compared with the control group (control, 2.7% ± 2.2%; FesvAd, 0.6% ± 0.2%; FesvAi, 0.3% ± 0.1%; FeivAs, 1.2% ± 0.2%; FeivAi, 0.6% ± 0.5%). The mean difference in body weight for the experimental groups, relative to the control group, was 30 ± 10 g. These results suggested that, in young male Wistar rats, both iron and vitamin A are essential to cause increases in body weight and various hematologic parameters.

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“…Effect of iron deficiency anemia on lipid peroxidation and antioxidant systems increased levels of free radicals in plasma and RBC of IDA patients 1,25,28. Previous studies also reported increased amount of lipid peroxidation by products in the erythrocytes and plasma 29,30 ,31. TBARS remained high as well as antioxidant enzymes.…”

mentioning

confidence: 83%

“…It is a particularly common disorder among infants, preschool-aged children, young women and older people, but it can occur at all ages and in any region. A high demand for iron during rapid growth, pregnancy and lactation, accompanied by dietary deficiencies and menstrual blood loss, are the most common causes of iron deficiency in children, young women and elderly population [28][29][30]. It affects one's development, growth and resistance to infections, and is associated with mortality among children younger than two years old 33.…”

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confidence: 99%

Effect of iron deficiency anemia on lipid peroxidation and antioxidant systems

Madhikarmi

Murthy

2012

J Coll Med Sci-Nepal

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Iron deficiency is one of the most widespread nutritional deficiencies in the world. Globally more than two billion people are suffering from iron deficiency anemia. The present study was designed to investigate the influence of a large number of factors known to be associated with oxidative stress. The case-control study determines the lipid peroxidation and antioxidants status in forty Iron deficiency anemia and forty healthy volunteers with their informed consent. All the parameters were assayed by spectrophotometric methods. Blood hemoglobin and plasma iron were decreased whereas total iron binding capacity was increased significantly in Iron deficiency anemia. The lipid peroxidation parameters like malondialdehyde, lipid hydroperoxide were significantly increased in Iron deficiency anemia. Both enzymatic; glutathione peroxidase, superoxide dismutase and catalase and non-enzymatic antioxidants; vitamin C, E and reduced glutathione were significantly decreased in Iron deficiency anemia case as compared to their healthy counterparts. Our findings suggest, increased lipid peroxidation products and reduced antioxidants system boost the oxidative stress state, hence deteriorating the condition of Iron deficiency anemia patients. Journal of College of Medical Sciences-Nepal,2011,Vol-7,No-4, 34-43 DOI: http://dx.doi.org/10.3126/jcmsn.v7i4.6739

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Effect of vitamin A supplementation on hematopoiesis in children with anemia

Cited by 7 publications

References 7 publications

Effect of a single high dose vitamin A supplementation on the hemoglobin status of children aged 6–59 months: propensity score matched retrospective cohort study based on the data of Ethiopian Demographic and Health Survey 2011

Effect of a single high dose vitamin A supplementation on the hemoglobin status of children aged 6–59 months: propensity score matched retrospective cohort study based on the data of Ethiopian Demographic and Health Survey 2011

Influence of Dietary Vitamin A and Iron Deficiency on Hematologic Parameters and Body Weight of Young Male Wistar Rats

Effect of iron deficiency anemia on lipid peroxidation and antioxidant systems

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