Effect of Vitamin A on Lung Function Test in patient with Chronic Bronchial Asthma

Abstract

In chronic bronchial asthma inflammation may be accompanied by intensive air flow limitation. Endogenous oxidants produced by overactive inflammatory cells destroy airway epithelium which slough into bronchial lumen and thus aggravates asthma. When oxidant overwhelm anti-oxidants, tissue injury and disease results. It is observed that decrease level of anti-oxidants in the lungs is a feature of chronic bronchial asthma and that there is a marked decrease of these levels during acute asthmatic attacks. These observations highlight the positive correlation between anti-oxidant therapy in asthmatic patients. The study was carried out to observe the changes in lung function in patients with chronic bronchial asthma both before and after supplementation of anti-oxidant vitamin A. Pulmonary function variables such as FVE, FEV1, FEV1/FVC%and PEFR were measured by spirometer in patients with chronic bronchial asthma both before and three month after supplementation of vitamin A 10,000 I.U orally daily. The mean FVC, FEV1, FEV1/FVC% and PEFR following vitamin A was unchanged significantly (P<0.001) than the pre supplementation values in patients with chronic bronchial asthma. This study reveals that no improvement of pulmonary functions occur after supplementation of anti-oxidant vitamin A in chronic bronchial asthma patients.TAJ 2014; 27(1): 10-13

Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

“…Thus, dysregulation of retinol metabolism will have a direct effect on the formation of keratin in thymic epithelial cells, resulting in declines in immune function [ 35 ]. Animal experiments have shown that retinol promotes the proliferation and separation of alveolar wall cells, improving damaged alveolar structures, and reducing the degree of emphysema, while retinol deficiency can lead to emphysema [ 36 ]. In the present study, paraquat reduced the levels of retinal and retinyl ester in lung tissue, suggesting that paraquat exposure can result in the destruction of airway epithelial integrity and declines in immune function.…”